Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells

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Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells is …
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scholarly articleQ13442814

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P356DOI10.2337/DB15-0376
P932PMC publication ID4587637
P698PubMed publication ID26085571

P2093author name stringJeffrey C Raum
Brett A Kaufman
Doris A Stoffers
David N Groff
Juxiang Yang
Scott A Soleimanpour
Alana M Ferrari
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathyQ24288778
Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiencyQ24306549
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoproteinQ39812323
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivationQ39816832
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretionQ43847819
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.Q45227245
NIX induces mitochondrial autophagy in reticulocytesQ45345768
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy.Q50453392
Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.Q53640894
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1Q73777239
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitusQ24562726
A mitochondrial protein compendium elucidates complex I disease biologyQ24655079
Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex IQ24683107
Increased islet apoptosis in Pdx1+/- miceQ24683719
Mechanisms of mitophagyQ27310261
Aup1-mediated regulation of Rtg3 during mitophagyQ27934793
Mitochondrial regulation of β-cell function: maintaining the momentum for insulin releaseQ28083598
Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceQ28506102
The diabetes susceptibility gene Clec16a regulates mitophagyQ28511990
Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathyQ28646237
A guided tour into subcellular colocalization analysis in light microscopyQ29547199
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse modelQ30421540
A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasisQ30441221
First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetesQ31928474
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with diseaseQ33559617
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppressionQ33577434
Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiencyQ33933229
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.Q34045740
The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple familiesQ34163172
Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetesQ34245476
Calcineurin signaling regulates human islet {beta}-cell survival.Q34401014
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility lociQ34518460
Regulation of pdx-1 gene expressionQ35022138
Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cellsQ35046909
UPR, autophagy, and mitochondria crosstalk underlies the ER stress responseQ35122358
Research resource: the pdx1 cistrome of pancreatic isletsQ35776350
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formationQ36452057
Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome.Q36619848
PINK1- and Parkin-mediated mitophagy at a glanceQ36851332
Inactivation of specific β cell transcription factors in type 2 diabetesQ37052883
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stressQ37419139
Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stressQ38050926
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperonesQ39655631
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)3475-3484
P577publication date2015-06-17
P1433published inDiabetesQ895262
P1476titleDiabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells
P478volume64

Reverse relations

cites work (P2860)
Q92256221ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes
Q90390792Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI
Q47694639Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.
Q49917575Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability
Q36284095Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival
Q38810900Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen
Q55434339Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p.
Q33769436High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy
Q47158224Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes
Q93080735Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy
Q33836028Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
Q36960085Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes
Q37732934PAX4 promotes PDX1-induced differentiation of mesenchymal stem cells into insulin-secreting cells
Q92402784The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes
Q28910204The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3
Q41689696Transcribing β-cell mitochondria in health and disease
Q49200841Type 1 diabetes genome-wide association studies: not to be lost in translation
Q92154034Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
Q52607218β-Cell Autophagy in Diabetes Pathogenesis.
Q89999400β-cell autophagy: Mechanism and role in β-cell dysfunction

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