GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00213-005-2212-8
P698PubMed publication ID15864560
P5875ResearchGate publication ID7872741

P50authorMarin VeldicQ75191736
P2093author name stringAlessandro Guidotti
Erminio Costa
Dennis R Grayson
John M Davis
Erbo Dong
Xianquan Zhang
James Auta
P2860cites workAn epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerabilityQ24544035
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1Q24556666
DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brainsQ24630392
A decrease of reelin expression as a putative vulnerability factor in schizophreniaQ24657918
GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neuronsQ28142612
A framework for consciousnessQ28205764
The physiological role of 5-HT2A receptors in working memoryQ28211470
Role of the reelin signaling pathway in central nervous system developmentQ28214353
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learningQ28217153
Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the ratQ28239157
Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humansQ28252305
GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controlsQ28275258
Imidazenil, a new anxiolytic and anticonvulsant drug, attenuates a benzodiazepine-induced cognition deficit in monkeysQ28303866
Hallucinations after withdrawal of baclofenQ28318103
Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathwayQ28508565
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain studyQ29616193
The contribution of the anterior cingulate cortex to executive processes in cognition.Q30578017
Input-dependent synaptic targeting of alpha(2)-subunit-containing GABA(A) receptors in synapses of hippocampal pyramidal cells of the rat.Q31900249
Molecular targets for the myorelaxant action of diazepam.Q31941952
Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depressionQ33239430
Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory.Q33886021
Microcolumns in the cerebral cortexQ33915529
GABAergic interneurons: implications for understanding schizophrenia and bipolar disorderQ33948632
Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.Q34094299
Catching up on schizophrenia: natural history and neurobiologyQ34122141
Interneurons unboundQ34186260
Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidenceQ34192699
Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesisQ34224434
Neurosteroid modulation of GABAA receptorsQ34275980
Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorderQ34331509
Neural synchrony indexes disordered perception and cognition in schizophreniaQ34368405
Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary reportQ34395443
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in miceQ34398750
GABA(A)-receptor subtypes: a new pharmacologyQ34442005
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Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepinesQ34742725
A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomesQ34983408
GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAsQ34992611
Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of toleranceQ35054106
The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputsQ35420341
Hallucinations and baclofenQ66695372
Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeysQ69650035
[3H]muscimol binding sites increased in autopsied brains of chronic schizophrenicsQ70158501
Synaptic target selectivity and input of GABAergic basket and bistratified interneurons in the CA1 area of the rat hippocampusQ71615814
Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortexQ73466870
Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophreniaQ73535859
Emerging principles of altered neural circuitry in schizophreniaQ73553170
Compartmentalized synthesis and degradation of proteins in neurons.Q35558440
GABA and Schizophrenia: A Review of Basic Science and Clinical StudiesQ35587241
GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability.Q35672461
Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunctionQ35810087
A GABAergic cortical deficit dominates schizophrenia pathophysiologyQ35974076
A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophreniaQ36070114
Benzodiazepines in the treatment of schizophrenia: a review and reappraisalQ36495525
GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunitsQ36790682
Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cellsQ37275701
Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam.Q38358611
Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findingsQ38465336
Biochemical evidence for two classes of GABA receptors in rat brainQ40251117
Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.Q40417870
GABAergic neurons and their role in cortical plasticity in primatesQ40790230
Benzodiazepines on trial: a research strategy for their rehabilitationQ41008175
Partial benzodiazepine agonists in schizophrenia: expectations and present clinical findingsQ41983126
Columnar architecture sculpted by GABA circuits in developing cat visual cortexQ42131999
Dendritic spine density in schizophrenia and depressionQ43525720
A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorderQ43751920
Prefrontal cortical representation of visuospatial working memory in monkeys examined by local inactivation with muscimolQ43766634
Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophreniaQ44014143
GABAA receptor subunit mRNA levels are differentially influenced by chronic FG 7142 and diazepam exposureQ44042421
In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areasQ44124552
Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortexQ44579696
Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology ConsortiumQ44715726
Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicityQ44771411
Specific GABAA circuits for visual cortical plasticity.Q44797119
Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.Q44824095
Immunohistochemical and immunoblot study of GABA(A) alpha1 and beta2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorderQ45003272
Two isoforms of glutamate decarboxylase: why?Q45345778
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.Q46022290
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptorsQ48236672
Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC.Q48238408
Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortexQ48251166
The reduced neuropil hypothesis: a circuit based model of schizophreniaQ48303124
Structural and functional basis for GABAA receptor heterogeneity.Q48316687
Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenicsQ48521493
Synapse-specific localization of NMDA and GABA(A) receptor subunits revealed by antigen-retrieval immunohistochemistryQ48546747
Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortexQ48632826
Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophreniaQ48826531
Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjectsQ48855793
Differences in the subregional and cellular distribution of GABAA receptor binding in the hippocampal formation of schizophrenic brainQ49018822
Differences between somatic and dendritic inhibition in the hippocampusQ49047383
Diazepam treatment of early signs of exacerbation in schizophrenia.Q51475042
Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction.Q51580740
Comparison of the effects of full and partial allosteric modulators of GABA(A) receptors on complex behavioral processes in monkeys.Q52052778
P433issue2
P921main subjectschizophreniaQ41112
P1104number of pages15
P304page(s)191-205
P577publication date2005-04-28
P1433published inPsychopharmacologyQ1422802
P1476titleGABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
P478volume180

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