Reelin in the Years: Controlling Neuronal Migration and Maturation in the Mammalian Brain

Reelin in the Years: Controlling Neuronal Migration and Maturation in the Mammalian Brain is …
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scholarly articleQ13442814

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P356DOI10.1155/2014/597395

P2093author name stringGabriella D'Arcangelo
P2860cites workThe Pafah1b complex interacts with the reelin receptor VLDLRQ21144460
Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasisQ21562423
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2Q22010158
Reelin is a ligand for lipoprotein receptorsQ22010835
Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylationQ22010836
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]Q24313605
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1Q24528128
Mouse disabled (mDab1): a Src binding protein implicated in neuronal developmentQ24532070
On the epigenetic regulation of the human reelin promoterQ24533209
Architecture of Purkinje cells of the reeler mutant mouse observed by immunohistochemistry for the inositol 1,4,5-trisphosphate receptor protein P400Q44234571
Determinants of cell shape and orientation: A comparative Golgi analysis of cell-axon interrelationships in the developing neocortex of normal and reeler miceQ44288034
Disabled-1 mRNA and protein expression in developing human cortexQ44311653
Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development.Q44315026
Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinasesQ44617813
Ultrastructural localization of reelin in the cortex in post-mortem human brainQ45250511
Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins.Q46545683
Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient miceQ46866779
Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neuronsQ48164936
The phenotypic characteristics of heterozygous reeler mouseQ48190249
The hippocampus of the reeler mutant mouse: fiber segregation in area CA1 depends on the position of the postsynaptic target cellsQ48210153
A panel of monoclonal antibodies against reelin, the extracellular matrix protein defective in reeler mutant miceQ48222828
Observations on the cerebellum of normal-reeler mutant mouse chimeraQ48288433
Expression of reelin, the gene responsible for the reeler mutation, in embryonic development and adulthood in the mouseQ48615103
Time of neuron origin in the hippocampus and dentate gyrus of normal and reeler mutant mice: An autoradiographic analysisQ48631274
Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression.Q48655898
Time of origin or corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: an autoradiographic analysisQ48671967
The embryonic development of the cerebellum in normal and reeler mutant miceQ48822644
Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortexQ48919857
Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler miceQ48941524
Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3betaQ34154141
Fyn tyrosine kinase is a critical regulator of disabled-1 during brain developmentQ34170326
Reelin promotes neuronal orientation and dendritogenesis during preplate splittingQ34179554
Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient miceQ34189780
Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampusQ34192066
The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.Q34289970
REELIN and schizophrenia: a disease at the interface of the genome and the epigenomeQ34302284
The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons.Q34310467
Histone deacetylase inhibitors decrease reelin promoter methylation in vitroQ34409611
A role for Cajal-Retzius cells and reelin in the development of hippocampal connections.Q34412567
Reelin mRNA expression during mouse brain developmentQ34428759
Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.Q34430000
Reelin modulates NMDA receptor activity in cortical neurons.Q34449067
Genomic organization of the mouse reelin gene.Q34451091
Developmental distribution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistryQ34456500
Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.Q34620344
The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signalingQ34628668
Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.Q34666158
NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin.Q34690936
A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migrationQ34714076
Beta1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex.Q34725108
Receptor clustering is involved in Reelin signalingQ24629473
Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deploymentQ24630634
Regulation of protein tyrosine kinase signaling by substrate degradation during brain developmentQ24633286
Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathwayQ24647125
The Reelin signaling pathway promotes dendritic spine development in hippocampal neuronsQ24648455
The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neuronsQ24648882
Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesisQ24653555
Interaction of reelin with amyloid precursor protein promotes neurite outgrowthQ24655186
A decrease of reelin expression as a putative vulnerability factor in schizophreniaQ24657918
Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expressionQ24672235
Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptorsQ24673808
Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibodyQ24675499
Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortexQ24677027
Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult ratsQ24685255
Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexesQ27641195
Proteins of the CNR family are multiple receptors for ReelinQ28141368
Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1Q28188030
Two modes of radial migration in early development of the cerebral cortexQ28200075
Neurons derived from radial glial cells establish radial units in neocortexQ28202112
Interaction of reelin signaling and Lis1 in brain developmentQ28212561
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learningQ28217153
Disabled1 regulates the intracellular trafficking of reelin receptorsQ28235683
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampusQ28236724
Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouseQ28248620
Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in miceQ28251984
Neuronal position in the developing brain is regulated by mouse disabled-1Q28251995
Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neuronsQ28254404
A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelinQ28259492
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeatsQ28261729
DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processingQ28261752
Absence of Fyn and Src causes a reeler-like phenotypeQ28272263
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouseQ34742022
Assessment of cognitive function in the heterozygous reeler mouseQ35103789
EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate nicheQ35178559
ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.Q35574962
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.Q36112064
Nucleokinesis in neuronal migrationQ36121319
Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zoneQ36303889
Reelin mouse mutants as models of cortical development disorders.Q36305098
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.Q36315309
Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1Q36342370
Laminating the hippocampusQ36423895
The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.Q36436017
Nckβ Interacts with Tyrosine-Phosphorylated Disabled 1 and Redistributes in Reelin-Stimulated NeuronsQ36549477
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortexQ36551237
Dual functions of Dab1 during brain developmentQ37033625
Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse.Q37156089
Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant miceQ37186834
Reelin controls position of autonomic neurons in the spinal cordQ37235566
Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway.Q37663266
Go or Stop? Divergent Roles of Reelin in Radial Neuronal MigrationQ37785418
Reelin modulates cytoskeletal organization by regulating Rho GTPasesQ37943329
Anatomical, Physiological and biochemical studies of the cerebellum fromreelermutant mouseQ39177078
The development of the hippocampus and dentate gyrus in normal and reeler miceQ39543631
Reelin induces EphB activationQ39586973
Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signalingQ39608994
Mechanisms of Cortical Development: A View From Mutations in MiceQ39811367
Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.Q40196818
Cortical development: View from neurological mutants two decades laterQ40441433
An early development defect in the cerebral cortex of the reeler mouse. A morphological study leading to a hypothesis concerning the action of the mutant geneQ41031618
The morphology of the hippocampus and dentate gyrus in normal and reeler miceQ41566209
Dual role of Cajal-Retzius cells and reelin in cortical developmentQ41606024
Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signalingQ41776314
Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues.Q42246337
Abnormal laminar position and dendrite development of interneurons in the reeler forebrain.Q42501695
The human reelin gene: isolation, sequencing, and mapping on chromosome 7.Q42651099
The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neuronsQ42681012
Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1.Q43140471
Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.Q43560391
Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortexQ43715204
The reelin pathway modulates the structure and function of retinal synaptic circuitryQ43753291
The role of Reelin in pathology of autismQ44194128
Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse.Q51299150
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.Q51874352
Executive functions in the heterozygous reeler mouse model of schizophrenia.Q51980418
Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.Q52165759
Developmental studies on the cerebellum from reeler mutant mouse in vivo and in vitro.Q52297358
Reelin binds alpha3beta1 integrin and inhibits neuronal migration.Q55034150
Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)Q56094596
Different origins and developmental histories of transient neurons in the marginal zone of the fetal and neonatal rat cortexQ28279194
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor proteinQ28290411
Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine densityQ28504750
Reelin signaling directly affects radial glia morphology and biochemical maturationQ28505272
Reelin signaling facilitates maturation of CA1 glutamatergic synapsesQ28506393
Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathwayQ28508565
Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesisQ28512150
Reelin activates SRC family tyrosine kinases in neuronsQ28513455
Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cordQ28564526
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2Q28566778
Rat neurological disease creeping is caused by a mutation in the reelin geneQ28569118
Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical laminationQ28572324
Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiationQ28585624
Evidence for a cell-specific action of Reelin in the spinal cordQ28586609
Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brainQ28587414
Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brainQ28592036
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethalityQ28592982
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain studyQ29616193
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophreniaQ29618963
A protein related to extracellular matrix proteins deleted in the mouse mutant reelerQ29618965
mTOR signaling at a glanceQ29619857
Dab1 is required for synaptic plasticity and associative learningQ30441312
Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouseQ30447427
Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellumQ30479515
Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortexQ30500605
Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cellsQ30535342
Reelin immunoreactivity in the adult primate brain: intracellular localization in projecting and local circuit neurons of the cerebral cortex, hippocampus and subcortical regionsQ31118323
Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteinsQ33202355
Role for Reelin in neurotransmitter release.Q33821827
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutationsQ33845128
The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipidsQ33958834
Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat KawasakiQ33966707
Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseasesQ34111923
Secreted Reelin molecules form homodimers.Q34140685
Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis.Q34150597
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)1-19
P577publication date2014-01-01
P1433published inAdvances in neuroscience (Hindawi)Q27725716
P1476titleReelin in the Years: Controlling Neuronal Migration and Maturation in the Mammalian Brain
P478volume2014