Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway.

scientific article published on 11 June 2013

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MP.2013.66
P932PMC publication ID3965840
P698PubMed publication ID23752244
P5875ResearchGate publication ID237096802

P50authorPascale ChavisQ59548164
Olivier LassalleQ86927930
P2093author name stringC Gonzalez-Campo
J Iafrati
L Bouamrane
M J Orejarena
P2860cites workReelin secreted by GABAergic neurons regulates glutamate receptor homeostasisQ21562423
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
Removing brakes on adult brain plasticity: from molecular to behavioral interventionsQ24634051
The Reelin signaling pathway promotes dendritic spine development in hippocampal neuronsQ24648455
The molecular neurobiology of depressionQ24656261
A decrease of reelin expression as a putative vulnerability factor in schizophreniaQ24657918
Emotion circuits in the brainQ27860733
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learningQ28217153
Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviorsQ28237853
Architecture of the prefrontal cortex and the central executiveQ28275511
Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine densityQ28504750
Mice with reduced NMDA receptor expression display behaviors related to schizophreniaQ28510751
Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memoryQ28568550
Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder.Q28588903
Dendritic spine pathology in neuropsychiatric disordersQ29615871
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonistsQ29618120
A protein related to extracellular matrix proteins deleted in the mouse mutant reelerQ29618965
Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memoryQ30466738
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responsesQ30471587
Anesthetics rapidly promote synaptogenesis during a critical period of brain development.Q33503645
Longitudinal magnetic resonance imaging study of cortical development through early childhood in autismQ33808718
The genetic variation of RELN expression in schizophrenia and bipolar disorderQ33908388
Rapamycin for treating Tuberous sclerosis and Autism spectrum disordersQ34024856
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.Q34025536
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortexQ34061150
Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseasesQ34111923
Extraordinary neoteny of synaptic spines in the human prefrontal cortex.Q34203392
Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephalyQ34228574
Maturation of Layer V Pyramidal Neurons in the Rat Prefrontal Cortex: Intrinsic Properties and Synaptic FunctionQ34275039
The heterozygous reeler mouse: behavioural phenotypeQ34329320
Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.Q34430000
Blockade of NMDA receptors unmasks a long-term depression in synaptic efficacy in rat prefrontal neurons in vitroQ34542776
Reelin, lipoprotein receptors and synaptic plasticityQ34575575
NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin.Q34690936
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposureQ34744471
Assessment of cognitive function in the heterozygous reeler mouseQ35103789
Bringing order to the glutamate chaos in schizophreniaQ35601575
Extracellular matrix abnormalities in schizophreniaQ35603175
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.Q36315309
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortexQ36954984
Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depressionQ37128042
The prefrontal cortex and its relation to behaviorQ37348930
New insights into the role of brain-derived neurotrophic factor in synaptic plasticityQ37356686
Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia.Q37624654
Prefrontal control of fear: more than just extinction.Q37715147
The dual role of the extracellular matrix in synaptic plasticity and homeostasisQ37800023
NMDA receptors, cognition and schizophrenia--testing the validity of the NMDA receptor hypofunction hypothesisQ37855203
Perineuronal nets protect fear memories from erasureQ39279816
Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.Q40196818
The stanley neuropathology consortium integrative database: a novel, web-based tool for exploring neuropathological markers in psychiatric disorders and the biological processes associated with abnormalities of those markersQ41885537
Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesisQ43177193
Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolationQ44692793
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticityQ44895962
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.Q45050775
Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins.Q46545683
Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient miceQ46866779
The phenotypic characteristics of heterozygous reeler mouseQ48190249
Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortexQ48252611
Reactivation of ocular dominance plasticity in the adult visual cortexQ48450295
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depressionQ48451127
Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats.Q49018146
SnapShot: genetics of autism.Q50345863
A developmental dissociation of context and GABA effects on extinguished fear in rats.Q50908696
Executive functions in the heterozygous reeler mouse model of schizophrenia.Q51980418
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectextracellular matrixQ193825
P304page(s)417-426
P577publication date2013-06-11
P1433published inMolecular PsychiatryQ6895973
P1476titleReelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway
P478volume19

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cites work (P2860)
Q36792448"Subpial Fan Cell" - A Class of Calretinin Neuron in Layer 1 of Adult Monkey Prefrontal Cortex
Q28079929A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.
Q41270458Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome
Q38718378Amplification of mGlu5-Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance.
Q55286626Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.
Q37710652CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells
Q26748761Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
Q27308949Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex
Q33752104Comparison of the adolescent and adult mouse prefrontal cortex proteome
Q30441312Dab1 is required for synaptic plasticity and associative learning
Q64075853Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model
Q48665243Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse.
Q26752594Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
Q38264895Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood
Q48326149Genetic and Developmental Perspective of Language Abnormality in Autism and Schizophrenia: One Disease Occurring at Different Ages in Humans?
Q37380077Going and stopping: dichotomies in behavioral control by the prefrontal cortex
Q33946570Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?
Q38726048Human dermal fibroblasts in psychiatry research
Q48034984Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.
Q36793075Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia
Q35952307Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex
Q37058606Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.
Q38165200Is the mTOR-signalling cascade disrupted in Schizophrenia?
Q37535064Late onset deficits in synaptic plasticity in the valproic acid rat model of autism
Q64786603Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes
Q28396555Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders
Q27334994Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders.
Q39008875Modeling of Autism Using Organoid Technology
Q89963801Modulation of Hippocampal Gamma Oscillations by Dopamine in Heterozygous Reeler Mice in vitro
Q26853035Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders
Q48869434Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.
Q41523202Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex.
Q36052695NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders
Q35262436Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Q26744747New Insights into Reelin-Mediated Signaling Pathways
Q35754455Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring
Q37636276Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.
Q38980258Prefrontal mechanisms of comorbidity from a transdiagnostic and ontogenic perspective
Q64934381Reelin Haploinsufficiency and Late-Adolescent Corticosterone Treatment Induce Long-Lasting and Female-Specific Molecular Changes in the Dorsal Hippocampus.
Q90680020Reelin Signaling Controls the Preference for Social Novelty in Zebrafish
Q28072540Reelin and Neuropsychiatric Disorders
Q59047757Reelin in the Years: Controlling Neuronal Migration and Maturation in the Mammalian Brain
Q33931251Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway.
Q38996374Reelin-Haploinsufficiency Disrupts the Developmental Trajectory of the E/I Balance in the Prefrontal Cortex.
Q26768609Reelin-Related Disturbances in Depression: Implications for Translational Studies
Q39043782Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses
Q48188639Relevance of the Proteolytic Processing of Reelin by ADAMTS-3 in Brain Functions.
Q26766246Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior
Q58749791Sex-dependent effects of in utero cannabinoid exposure on cortical function
Q30366954Stress and Fear Extinction.
Q26746042Structural Insights into Reelin Function: Present and Future
Q89819985Two Novel Loci of RELN Associated With Antipsychotics Response in Chinese Han Population
Q30437910dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.

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