IL-21 is critical for GVHD in a mouse model

scientific article

IL-21 is critical for GVHD in a mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/BMT.2009.223
P932PMC publication ID3403836
P698PubMed publication ID19718060
P5875ResearchGate publication ID26777819

P2093author name stringK Ozawa
K Ozaki
K Sato
W J Leonard
I Oh
K Hatanaka
A Meguro
H Matsu
R Tatara
P2860cites workA critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa miceQ37083674
Interleukin-21 is required for the development of type 1 diabetes in NOD miceQ37163453
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantationQ37371294
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.Q42064178
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivoQ43459130
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humansQ45874932
An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxinQ71881409
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effectQ73785060
Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantationQ77293917
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cellsQ79270308
Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen speciesQ104282138
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte functionQ24290522
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 responseQ24307467
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cellsQ24673146
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chainQ24673607
Interleukin-21 inhibits dendritic cell activation and maturationQ28191392
A critical role for IL-21 in regulating immunoglobulin productionQ28215868
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6Q28288702
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Cytokines and immunodeficiency diseasesQ34572193
The IL-21 receptor augments Th2 effector function and alternative macrophage activationQ34682153
Cytokine and cytokine receptor pleiotropy and redundancyQ34693494
IL-21 signaling is critical for the development of type I diabetes in the NOD mouseQ34823699
Graft-versus-host diseaseQ36793622
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)723-729
P577publication date2009-08-31
P1433published inBone Marrow TransplantationQ4941523
P1476titleIL-21 is critical for GVHD in a mouse model
P478volume45

Reverse relations

cites work (P2860)
Q35112265Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
Q34643444Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease
Q35669245Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes
Q93031404Central Roles of OX40L-OX40 Interaction in the Induction and Progression of Human T Cell-Driven Acute Graft-versus-Host Disease
Q46779685Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation.
Q26766361IL-21 Signaling in Immunity
Q36923019IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation
Q38243870IL-21 as a therapeutic target in inflammatory disorders
Q40656321IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner.
Q34587940IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation.
Q64110652Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease
Q34615453Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
Q33802076Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation
Q36107077Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells
Q48290042Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease.
Q37900645Regulatory T cells and IL-17-producing cells in graft-versus-host disease
Q37973866The IL-17 differentiation pathway and its role in transplant outcome
Q88613990The Inflammatory Cytokine IL-21 is Expressed by Splenic Neutrophils in Response to Transplantation of Allogeneic Cells
Q38712496Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease

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