CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle

scientific article

CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPGI.00102.2012
P932PMC publication ID3404568
P698PubMed publication ID22538403
P5875ResearchGate publication ID224854769

P2093author name stringRaj K Goyal
Xue-Dao He
P2860cites workActivation of small conductance Ca(2+)-dependent K+ channels by purinergic agonists in smooth muscle cells of the mouse ileumQ73653916
Intracellular calcium events activated by ATP in murine colonic myocytesQ74013587
Nitric oxide suppresses a Ca(2+)-stimulated Cl- current in smooth muscle cells of opossum esophagusQ74611970
Novel regulation of the A-type K+ current in murine proximal colon by calcium-calmodulin-dependent protein kinase IIQ77393667
High-conductance chloride channels generate pacemaker currents in interstitial cells of CajalQ78439549
Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinaseQ24290991
Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cellsQ28139585
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cellsQ28322032
Imaging of nitric oxide in nitrergic neuromuscular neurotransmission in the gutQ28475168
TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmissionQ28588968
TREK-1 channels do not mediate nitrergic neurotransmission in circular smooth muscle from the lower oesophageal sphincterQ33673081
Molecular structure and physiological function of chloride channelsQ34120773
Calcium-activated chloride channels.Q34394148
Role of sarcoplasmic reticulum in control of membrane potential and nitrergic response in opossum lower esophageal sphincterQ35045889
Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II.Q35098759
Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emergingQ36224105
Smooth muscle signalling pathways in health and diseaseQ37217197
Phosphorylation alters the pharmacology of Ca(2+)-activated Cl channels in rabbit pulmonary arterial smooth muscle cellsQ37434471
CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channelsQ40274743
KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.Q40337717
Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II.Q40509466
Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride currentQ40593816
Regulation of a human chloride channel. a paradigm for integrating input from calcium, type ii calmodulin-dependent protein kinase, and inositol 3,4,5,6-tetrakisphosphateQ40816228
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).Q42824754
A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activityQ43286789
Role of Ca2+-activated Cl- channels and MLCK in slow IJP in opossum esophageal smooth muscleQ44028464
Chloride-mediated inhibitory junction potentials in opossum esophageal circular smooth muscleQ44929471
Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea-pig ileum circular muscleQ45301028
Apamin-resistant post-stimulus hyperpolarization in the circular muscle of the guinea-pig ileumQ46402358
Nitric oxide involvement in the peptide VIP-associated inhibitory junction potential in the guinea-pig ileumQ46507250
The nature of noncholinergic membrane potential responses to transmural stimulation in guinea pig ileumQ46689692
Evidence for NO. redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut.Q46822571
Cable properties of smooth muscleQ46983492
An intermediate conductance K+ channel in the cell membrane of mouse intestinal smooth muscleQ47961926
Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAsQ48284298
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.Q50909381
Small conductance Ca2+-activated K+ channels are regulated by Ca2+-calmodulin-dependent protein kinase II in murine colonic myocytes.Q53913907
Chloride-mediated junction potentials in circular muscle of the guinea pig ileumQ54286114
Chloride-mediated inhibitory junction potentials in opossum esophageal circular smooth muscleQ68219923
Conductance change during the inhibitory potential in the guinea‐pig taenia coliQ70489806
Nitric oxide activates multiple potassium channels in canine colonic smooth muscleQ71490948
Caffeine- and carbachol-induced Cl- and cation currents in single opossum esophageal circular muscle cellsQ71836387
Ca2+ and Ca(2+)‐activated Cl‐ currents in rabbit oesophageal smooth muscleQ72079416
Opposing roles of K(+) and Cl(-) channels in maintenance of opossum lower esophageal sphincter toneQ73230223
P433issue2
P304page(s)G240-6
P577publication date2012-04-26
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleCaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle
P478volume303

Reverse relations

cites work (P2860)
Q53185315CrossTalk opposing view: Interstitial cells are not involved and physiologically important in neuromuscular transmission in the gut.
Q42875951Depolarization-induced depression of inhibitory transmission in cerebellar Purkinje cells
Q54314752Differential functional role of purinergic and nitrergic inhibitory cotransmitters in human colonic relaxation.
Q39480241Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
Q87221723Rebuttal from Raj K Goyal
Q50323723Relaxin influences ileal muscular activity through a dual signaling pathway in mice
Q24614229Structure activity relationship of synaptic and junctional neurotransmission
Q38866040Vascular CaMKII: heart and brain in your arteries

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