Smooth muscle signalling pathways in health and disease

scientific article published on December 2008

Smooth muscle signalling pathways in health and disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1582-4934.2008.00552.X
P932PMC publication ID2692531
P698PubMed publication ID19120701
P5875ResearchGate publication ID23718446

P2093author name stringH R Kim
K G Morgan
S Appel
S S Gangopadhyay
S Vetterkind
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'Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidenceQ81796391
Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expressionQ77419139
Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosisQ77839175
F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogsQ78157384
Use of actin isoform-specific antibodies to probe the domain structure in three smooth musclesQ78364095
Ultrastructure of airway smooth muscleQ79096132
ROCK1 phosphorylates and activates zipper-interacting protein kinaseQ79422103
Myosin phosphatase regulatory pathways: different functions or redundant functions?Q79494361
Reduction of Calponin h1 expression in human colon cancer blood vesselsQ80813696
Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17Q81134303
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cellsQ22009929
Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinaseQ24300498
p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoAQ24315196
Cloning of cDNAs encoding human caldesmonsQ24316136
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesisQ24559949
Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actinQ24619727
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscleQ24646740
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Integrins: bidirectional, allosteric signaling machinesQ27860700
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase IalphaQ28138136
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphataseQ28140582
Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscleQ28143022
Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memoryQ28189465
Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase IIQ28238565
Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylationQ28238773
Regulation of myosin light chain kinase and telokin expression in smooth muscle tissuesQ28246127
Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortasQ28261133
Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathyQ28261564
Inhibition of smooth muscle actin-activated myosin Mg2+-ATPase activity by caldesmonQ28261733
Targeting of a novel Ca+2/calmodulin-dependent protein kinase II is essential for extracellular signal-regulated kinase-mediated signaling in differentiated smooth muscle cellsQ28268020
Myosin light chain phosphatase: subunit composition, interactions and regulationQ28274342
Stimulation of recombinant Cav3.2, T‐type, Ca2+ channel currents by CaMKIIγCQ28345043
Calponin is required for agonist‐induced signal transduction ‐ evidence from an antisense approach in ferret smooth muscleQ28365703
Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actinQ28512937
CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migrationQ28566747
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinaseQ28570031
Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscleQ38336310
Calponin and Mitogen-activated Protein Kinase Signaling in Differentiated Vascular Smooth MuscleQ39453703
The function of myosin and myosin light chain kinase phosphorylation in smooth muscleQ39494677
Regulation of vascular smooth muscle tone by N-terminal region of caldesmon. Possible role of tethering actin to myosinQ39527659
Adenovirus-mediated calponin h1 gene therapy directed against peritoneal dissemination of ovarian cancer: bifunctional therapeutic effects on peritoneal cell layer and cancer cellsQ40236225
Caldesmon is an integral component of podosomes in smooth muscle cellsQ40295875
The multifunctional calcium/calmodulin-dependent protein kinase: from form to functionQ40543241
The role of calponin in the gene profile of metastatic cells: inhibition of metastatic cell motility by multiple calponin repeatsQ40602177
Actin isoformsQ40883539
Mice lacking smooth muscle calponin display increased bone formation that is associated with enhancement of bone morphogenetic protein responsesQ40979589
Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histonesQ40990389
Signal Transduction through MAP Kinase CascadesQ41750250
Calponin phosphorylation in vitro and in intact muscleQ41844386
CaMKIIT287 and T305 regulate history-dependent increases in alpha agonist-induced vascular toneQ41913428
Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptidesQ41991240
Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activityQ42148077
Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase.Q42174337
A chemical procedure for loading the calcium indicator acquorin into mammalian working myocardiumQ42256242
A Role for Ca 2+ /Calmodulin-Dependent Protein Kinase II in the Mitogen-Activated Protein Kinase Signaling Cascade of Cultured Rat Aortic Vascular Smooth Muscle CellsQ42444916
Regulation of vascular smooth muscle tone by caldesmonQ42455174
Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2.Q42456670
Contraction of single vascular smooth muscle cells by phenylephrine at constant [Ca2+]iQ42459944
Cholinergic receptor-mediated differential cytoskeletal recruitment of actin- and integrin-binding proteins in intact airway smooth muscleQ42465029
Ca2+-independent phosphorylation of myosin in rat caudal artery and chicken gizzard myofilamentsQ42470494
Modulation of gelsolin-induced actin-filament severing by caldesmon and tropomyosin and the effect of these proteins on the actin activation of myosin Mg(2+)-ATPase activityQ42981997
Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscleQ43540351
Inhibition of the relative movement of actin and myosin by caldesmon and calponinQ43564183
Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinaseQ43564868
Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinaseQ43682386
Functional interaction of calcium-/calmodulin-dependent protein kinase II and cytosolic phospholipase A(2).Q43691936
Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxationQ43696129
Selected contribution: roles of focal adhesion kinase and paxillin in the mechanosensitive regulation of myosin phosphorylation in smooth muscleQ43710099
Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cellsQ43770344
Site-specific mutations in the myosin binding sites of actin affect structural transitions that control myosin binding.Q43797230
CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscleQ43906796
Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17.Q43953881
The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscleQ44067085
Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary arteryQ44404578
Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscleQ44477015
Role of Crk-associated substrate in the regulation of vascular smooth muscle contractionQ44529231
Characterization of mitotically phosphorylated caldesmonQ44541236
Unzipping the Role of Myosin Light Chain Phosphatase in Smooth Muscle Cell RelaxationQ44608924
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membraneQ44630339
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.Q44724692
Calponin and the composition of smooth muscle thin filamentsQ44771599
Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca²⁺ sensitization in smooth muscleQ44881093
Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotidesQ44934588
Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscleQ45206429
Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain.Q46137514
Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscleQ46505843
CaMKII-delta isoform regulation of neointima formation after vascular injuryQ46838371
Role of ERK1/2 in uterine contractility and preterm labor in ratsQ47794719
Expression of the smooth muscle calponin gene in human osteosarcoma and its possible association with prognosisQ47916132
Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphataseQ28576642
ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and laborQ28576653
iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscleQ28584137
Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouseQ28586468
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear TranslocationQ28609161
Invited review: cross-bridge regulation by thin filament-associated proteinsQ28609856
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Focal adhesion kinase: in command and control of cell motilityQ29615192
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in MammalsQ29619598
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension developmentQ30164536
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerQ30304130
Contractile properties and proteins of smooth muscles of a calponin knockout mouseQ30306574
Localization of isoactins in isolated smooth muscle thin filaments by double gold immunolabelingQ30451222
Identification of the endogenous smooth muscle myosin phosphatase-associated kinaseQ30454233
Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.Q30465871
Actin isoform expression, cellular heterogeneity and contractile function in smooth muscleQ30471072
Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cellsQ30480258
Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinaseQ30661698
Caldesmon binding to actin is regulated by calmodulin and phosphorylation via different mechanismsQ30890391
Impaired arterial pressure regulation during exercise due to enhanced muscular vasodilatation in calponin knockout miceQ30980897
Differential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscleQ31132909
cGMP-dependent protein kinase phosphorylates and inactivates RhoA.Q31855673
Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotypeQ33342786
New insights into the control of MAP kinase pathwaysQ33783573
Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins.Q33879088
Functional plasticity of CH domains.Q34120320
Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferationQ34155173
Enhanced baroreflex sensitivity in free-moving calponin knockout miceQ34159173
A novel troponin T-like protein (calponin) in vascular smooth muscle: interaction with tropomyosin paracrystals.Q34170838
Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.Q34178395
Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinaseQ34187069
Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.Q34264656
Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal periodQ34284765
At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptideQ34287810
Interaction of smooth muscle calponin with phospholipidsQ34305077
Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscleQ34310352
Calponin: thin filament-linked regulation of smooth muscle contractionQ34337302
Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle.Q34338514
Mammalian calponin. Identification and expression of genetic variantsQ34354319
A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterizationQ34389858
Expression and epitopic conservation of calponin in different smooth muscles and during developmentQ34431645
M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cellsQ34463849
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzymeQ34472571
Differential transmission of actin motion within focal adhesionsQ34598084
Cytoplasmic gamma-actin contributes to a compensatory remodeling response in dystrophin-deficient muscleQ34600184
Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosisQ34613211
Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.Q34712315
Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphataseQ35026712
The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction.Q35046507
The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses.Q35148551
Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung.Q35546483
Suppression of cancer phenotypes through a multifunctional actin-binding protein, calponin, that attacks cancer cells and simultaneously protects the host from invasionQ36306733
Myosin filament assembly in an ever-changing myofilament lattice of smooth muscleQ36308616
Models of contractile units and their assembly in smooth muscleQ36333391
Phosphorylation of caldesmon during smooth muscle contraction and cell migration or proliferationQ36384590
Cytoplasmic free calcium, myosin light chain phosphorylation, and force in phasic and tonic smooth muscleQ36434266
Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocityQ36626274
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.Q36729109
Structure and mechanics of integrin-based cell adhesion.Q36744293
Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitorsQ36780496
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthmaQ36807115
Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependentQ36893091
Synergistic control of cell adhesion by integrins and syndecans.Q36986535
Interactions of airway smooth muscle cells with their tissue matrix: implications for contractionQ37038045
Integrins in angiogenesis and lymphangiogenesisQ37170752
Pressure‐induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behaviorQ38293398
Phosphorylation of phospholamban in aortic smooth muscle cells and heart by calcium/calmodulin-dependent protein kinase II.Q38305963
Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesisQ38326577
Contractile filament architecture and force transmission in swine airway smooth muscleQ47951034
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.Q48077108
Calponin phosphorylation in cerebral cortex microvessels mediates sustained vasoconstriction after brain traumaQ48107590
Inhibitors of calmodulin-dependent protein kinase are nonspecific blockers of voltage-dependent K+ channels in vascular myocytes.Q48131672
Focal adhesion signaling is required for myometrial ERK activation and contractile phenotype switch before laborQ48674489
Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinaseQ49239375
A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switchQ52170189
Regulation of force in skinned, single cells of ferret aortic smooth muscleQ52423831
Inhibition of CaM kinase II activation and force maintenance by KN-93 in arterial smooth muscleQ53948343
Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcomaQ54096260
Cell surface actin remodeling.Q55042306
A novel troponin T-like protein (calponin) in vascular smooth muscleQ55919466
Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscleQ57464815
Loss of calponin h1 in renal angiomyolipoma correlates with aggressive clinical behaviorQ57648372
Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase IIQ59060551
The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiationQ66960351
Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cellsQ67864802
Inhibition of actin-tropomyosin activation of myosin MgATPase activity by the smooth muscle regulatory protein caldesmonQ67901639
Transient myosin phosphorylation at constant Ca2+ during agonist activation of permeabilized arteriesQ68030577
Phosphorylation of smooth muscle myosin light chain kinase by Ca2+/calmodulin-dependent protein kinase II: comparative study of the phosphorylation sitesQ68454506
Phosphorylation of smooth muscle caldesmon by calmodulin-dependent protein kinase II. Identification of the phosphorylation sitesQ68479828
Smooth muscle specific expression of calponinQ68624318
Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorinQ68773803
Effects of dihydropyridines on stress, myosin phosphorylation, and V0 in smooth muscleQ68995502
Agonist-specific myosin phosphorylation and intracellular calcium during isometric contractions of arterial smooth muscleQ69619056
Norepinephrine and GTP-gamma-S increase myofilament Ca2+ sensitivity in alpha-toxin permeabilized arterial smooth muscleQ69845279
Modulation of smooth muscle actomyosin ATPase by thin filament associated proteinsQ69996134
Vascular smooth muscle: the first recorded Ca2+ transientsQ70613727
Identification of the regulatory site in smooth muscle calponin that is phosphorylated by protein kinase CQ70614495
Actin and tropomyosin variants in smooth muscles. Dependence on tissue typeQ70675843
Identification of mitogen-activated protein kinase phosphorylation sequences in mammalian h-CaldesmonQ70680932
Actin isoform compartments in chicken gizzard smooth muscle cellsQ72001035
Characterization of the regulatory domain of gizzard calponin. Interactions of the 145-163 region with F-actin, calcium-binding proteins, and tropomyosinQ72167662
Regulation of protein kinase C by the cytoskeletal protein calponinQ73006688
Effects of the phosphorylation of myosin phosphatase by cyclic GMP-dependent protein kinaseQ73106014
Caldesmon inhibits Arp2/3-mediated actin nucleationQ73128366
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylationQ73316337
Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanomaQ73480562
Calponin and h-caldesmon expression in synovial sarcoma; the use of calponin in diagnosisQ73480699
Thin and thick filament regulation of contractility in experimental cerebral vasospasmQ73483673
Coupling of Ca(2+) to CREB activation and gene expression in intact cerebral arteries from mouse : roles of ryanodine receptors and voltage-dependent Ca(2+) channelsQ73675143
Ca2+-calmodulin-dependent protein kinase II-dependent activation of contractility in ferret aortaQ74007824
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ OscillationsQ74016176
Altered mechanical properties in smooth muscle of mice with a mutated calponin locusQ74104785
Cytoskeletal targeting of calponin in differentiated, contractile smooth muscle cells of the ferretQ74271290
Two distinct actin‐binding sites of smooth muscle calponinQ74279324
Electron microscopic study of actin polymerization in airway smooth muscleQ75364945
P433issue6A
P407language of work or nameEnglishQ1860
P921main subjecthuman musculoskeletal systemQ726543
tissueQ40397
P304page(s)2165-2180
P577publication date2008-12-01
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleSmooth muscle signalling pathways in health and disease
P478volume12

Reverse relations

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