Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow

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Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1500775
P932PMC publication ID4592819
P698PubMed publication ID26355151

P2093author name stringYing Wang
Linda F Thompson
Rodger P McEver
Zhenghui Liu
Tadayuki Yago
Hiroki Tsukamoto
P2860cites workEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
Regulation of neutrophil function by adenosineQ24620317
Adenosine receptors: therapeutic aspects for inflammatory and immune diseasesQ24651475
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flowQ27027232
The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammationQ27319448
Ratio of local to systemic chemokine concentrations regulates neutrophil recruitmentQ28346168
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonistsQ28354178
Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow.Q36325671
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.Q36369393
Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flowQ36843799
Compartmentalization of ITAM and integrin signaling by adapter moleculesQ36877284
Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migrationQ37201168
How chemokines invite leukocytes to danceQ37246681
The ins and outs of leukocyte integrin signalingQ37419383
Regulation of lymphocyte function by adenosineQ38024675
Talin and kindlin: the one-two punch in integrin activationQ38183284
Purinergic signalling and immune cellsQ38263455
Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1.Q39508042
Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 bindingQ40409226
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activationQ40811225
Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants.Q41090098
Chemokines and the signaling modules regulating integrin affinityQ42177472
Syk is required for integrin signaling in neutrophilsQ43968751
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.Q44278529
C-terminal SRC kinase controls acute inflammation and granulocyte adhesion.Q51027815
Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Q51049232
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptorsQ57731080
Effect of adenosine on the expression of beta(2) integrins and L-selectin of human polymorphonuclear leukocytes in vitroQ71131920
Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flowQ73406513
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsQ28585779
Vav GEFs are required for beta2 integrin-dependent functions of neutrophilsQ28590406
Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in miceQ28593286
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in miceQ28594915
Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipramQ30304324
Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophilsQ30311882
Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rollingQ30426195
Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophilsQ30427418
Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient miceQ30432457
CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivoQ30434720
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cellsQ30435569
A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injuryQ30436482
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rollingQ30439982
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.Q30440643
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognitionQ30443210
Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injuryQ30444009
P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flowQ30453100
Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivoQ30469729
Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathwaysQ30494206
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulationQ30514206
Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.Q30514480
Core 1-derived O-glycans are essential E-selectin ligands on neutrophilsQ33927218
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptorQ33933737
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA.Q33988753
E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rollingQ34033865
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases.Q35132147
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.Q35651662
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.Q35747902
Neutrophils use both shared and distinct mechanisms to adhere to selectins under static and flow conditionsQ35764552
Intracellular signalling controlling integrin activation in lymphocytesQ36167584
Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophilsQ36223991
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functionsQ36236889
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3880-3889
P577publication date2015-09-09
P1433published inJournal of ImmunologyQ3521441
P1476titleMulti-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow
P478volume195

Reverse relations

cites work (P2860)
Q94463940Anti-Inflammatory Profile of Jungia sellowii Less. by Downregulation of Proinflammatory Mediators and Inhibition of NF-κB and p38 Pathways
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Q41810389Dampening neutrophil integrins
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Q28078773Intercellular Interactions as Regulators of NETosis
Q48316176Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion.
Q52353629Purinergic Regulation of Neutrophil Function.
Q88204080Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils
Q46215378Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.
Q93062525Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Q96230894The adenosine pathway in immuno-oncology
Q60922703Vascular endothelial cell expression of JAK2 is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

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