ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice

scientific article

ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPLUNG.00372.2014
P932PMC publication ID4593838
P698PubMed publication ID26276827

P50authorStephanie A ShoreQ92901087
P2093author name stringJames K Liao
Chan Y Park
David I Kasahara
Youngji Cho
Joel A Mathews
Allison P Wurmbrand
Gabrielle Hunt
P2860cites workRocks: multifunctional kinases in cell behaviourQ24303641
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinaseQ24321633
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cellsQ24646579
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinaseQ28117594
Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analogQ28184649
Identification of a putative target for Rho as the serine-threonine kinase protein kinase NQ28273890
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in miceQ28287728
Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -IIQ28565264
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein RhoQ29614250
A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit tracheaQ30443946
Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptorsQ31834393
Ozone. The good, the bad, and the uglyQ33875275
Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in miceQ34345652
Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthmaQ34550153
Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscleQ34801127
CCL20, γδ T cells, and IL-22 in corneal epithelial healingQ35105392
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal deathQ35107897
Asthma and respiratory irritants (ozone)Q35133050
Role of Rho kinase isoforms in murine allergic airway responses.Q35687203
Time course of airway hyperresponsiveness induced by ozone in dogsQ71070261
Ozone-induced pulmonary lesions. Severe epithelial changes following sublethal dosesQ71404056
Mast cells modulate acute ozone-induced inflammation of the murine lungQ72604902
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylationQ73316337
Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cellsQ73552808
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitizationQ77788850
Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challengesQ80149702
Regulation of airway smooth muscle RhoA/ROCK activities by cholinergic and bronchodilator stimuliQ83994169
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contractionQ35874754
Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A.Q35936578
Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiencyQ36057251
High-throughput screening for modulators of cellular contractile forceQ36311468
The Rho kinases I and II regulate different aspects of myosin II activityQ36320914
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundlesQ36321444
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17Q36502818
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injuryQ36540884
Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13.Q36904352
Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholineQ37054496
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protectionQ37079168
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient miceQ37092280
Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.Q37160884
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesionsQ38347826
Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancyQ38370108
Rho-associated kinase signaling is required for osteopontin-induced cell invasion through inactivating cofilin in human non-small cell lung cancer cell linesQ38893972
Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxisQ40547419
A genetic model for evaluation of susceptibility to ozone-induced inflammationQ41233545
Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65.Q41331100
Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migrationQ41821246
Chemokine regulation of ozone-induced neutrophil and monocyte inflammation.Q42545182
Input impedance and peripheral inhomogeneity of dog lungsQ42608841
Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cellsQ43077700
Long-term ambient ozone concentration and the incidence of asthma in nonsmoking adults: the AHSMOG StudyQ43421511
Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in miceQ43718492
The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophilsQ43760136
Traction fields, moments, and strain energy that cells exert on their surroundingsQ43879155
Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cellsQ43879158
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.Q43883117
Ozone-induced airway hyperresponsiveness is reduced in immature miceQ43884306
Stiffness changes in cultured airway smooth muscle cellsQ44101877
CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposureQ45054218
Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administrationQ45302180
Contractile effect of bombesin on guinea pig lung in vitro: involvement of gastrin-releasing peptide-preferring receptorsQ46202326
Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation.Q46240014
Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylationQ46383399
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contractionQ46578936
The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammationQ46589827
Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized miceQ46721866
Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice.Q51481243
Ozone-induced airway hyperreactivity in the guinea pig.Q53908204
Susceptibility to ozone-induced inflammation. II. Separate loci control responses to acute and subacute exposures.Q54251596
O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans.Q54430630
Effect of ozone on bronchial reactivity in atopic and nonatopic subjectsQ54565436
Physical forces during collective cell migrationQ55920182
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)L736-46
P577publication date2015-08-14
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice
P478volume309

Reverse relations

cites work (P2860)
Q90208860Androgens augment pulmonary responses to ozone in mice
Q47907010Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-releasing Peptide
Q47547678Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction.
Q38811516Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.
Q42008919Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure
Q38882099Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease.
Q28088751Ozone-induced airway hyperresponsiveness: roles of ROCK isoforms
Q37286847Plasminogen activator inhibitor-1 does not contribute to the pulmonary pathology induced by acute exposure to ozone
Q37086168ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells
Q91953747Regulation of IL-17A and implications for TGF-β1 comodulation of airway smooth muscle remodeling in severe asthma
Q48033800Role of ROCK2 in CD4+ cells in allergic airways responses in mice
Q47324079The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
Q92910663The interleukin-33 receptor contributes to pulmonary responses to ozone in male mice: role of the microbiome
Q26357739The next generation of risk assessment multiyear study - highlights of findings, applications to risk assessment, and future directions
Q92239614Transcriptional Effects of Ozone and Impact on Airway Inflammation

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