PDE4 inhibition suppresses IL-17-associated immunity in dry eye disease

scientific article

PDE4 inhibition suppresses IL-17-associated immunity in dry eye disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.11-9110
P932PMC publication ID3406885
P698PubMed publication ID22577075
P5875ResearchGate publication ID224940255

P50authorReza DanaQ16206939
P2093author name stringWilliam Stevenson
Jing Hua
Sunil K Chauhan
Francisco Amparo
Zahra Sadrai
Andre Okanobo
Yihe Chen
Thomas H Dohlman
P2860cites workAntiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary diseaseQ44484408
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Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2.Q45930063
Modulation of integrin alpha4beta1 (VLA-4) in dry eye diseaseQ46209348
Inflammation in dry eye.Q46372528
The controlled-environment chamber: a new mouse model of dry eye.Q46618772
Ophthalmologist Perceptions Regarding Treatment of Moderate-to-Severe Dry Eye: Results of a Physician SurveyQ61759590
Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal KeratoconjunctivitisQ61851332
Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacityQ73529161
Cyclosporin A increases tear fluid secretion via release of sensory neurotransmitters and muscarinic pathway in miceQ77753274
Recurrence after topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren's syndromeQ79885702
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
PDE4 inhibitors: current statusQ24651926
Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye.Q33486416
Phosphodiesterase 4 inhibitors as novel anti-inflammatory agentsQ33695784
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functionsQ33860484
Mechanisms of action of cyclosporine.Q33908049
Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathwayQ33938235
Characterization of effector T cells in dry eye diseaseQ34065949
High-frequency topical cyclosporine 0.05% in the treatment of severe dry eye refractory to twice-daily regimenQ34076208
The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells.Q34317970
Topical omega-3 and omega-6 fatty acids for treatment of dry eye.Q34749224
JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cellsQ36380244
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insightsQ37732574
IL-23 in the pathogenesis of rheumatoid arthritisQ37736566
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Q37778289
Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritisQ39625191
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?Q40895430
Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.Q40948258
Tailoring cAMP-signalling responses through isoform multiplicityQ41516369
Secretion of proinflammatory cytokines by human conjunctival epithelial cellsQ42441794
Role of Th17 cells in the immunopathogenesis of dry eye diseaseQ42694095
Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye diseaseQ43723395
The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivoQ43897053
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)3584-3591
P577publication date2012-06-14
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titlePDE4 inhibition suppresses IL-17-associated immunity in dry eye disease
P478volume53

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cites work (P2860)
Q50098128Corneal Tissue From Dry Eye Donors Leads to Enhanced Graft Rejection.
Q90467874Increased risk of keratopathy after psoriasis: A nationwide population-based study
Q36990222Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome
Q55064864Pathological conversion of regulatory T cells is associated with loss of allotolerance.
Q64066727Rebamipide ophthalmic solution modulates the ratio of T helper cell 17/regulatory T cells in dry eye disease mice
Q36243207Sjögren syndrome: what and where are we looking for?
Q36986476Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.
Q37374838T helper cytokines in dry eye disease
Q36926074The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease
Q38219053The eye: a window of opportunity in rheumatoid arthritis?

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