The proteasome: a central regulator of inflammation and macrophage function

scientific article

The proteasome: a central regulator of inflammation and macrophage function is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1035443875
P356DOI10.1385/IR:31:3:243
P698PubMed publication ID15888915

P2093author name stringStefanie N Vogel
Nilofer Qureshi
Christopher J Papasian
Asaf A Qureshi
David C Morrison
Charles Van Way
P2860cites workDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2Q24290990
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Q24310398
Structure and function of lipopolysaccharide binding proteinQ24324774
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agentQ24613185
Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductaseQ24645348
Innate immune recognitionQ27860721
The complete primary structure of mouse 20S proteasomesQ28141380
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transductionQ28205376
Identity of tumour necrosis factor and the macrophage-secreted factor cachectinQ28286678
A toll-like receptor that prevents infection by uropathogenic bacteriaQ28504943
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathwayQ28505835
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAQ28513215
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling eventsQ28594630
Regulation of the mevalonate pathwayQ29547763
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteinQ29615189
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Bacterial lipopolysaccharide can enter monocytes via two CD14-dependent pathways.Q31973408
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genesQ33702208
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activationQ33733316
The proteasome activator 11 S REG (PA28) and class I antigen presentationQ33796158
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharideQ33938936
Intracellular targeting of the proteasomeQ33944912
The function of the proteasome system in MHC class I antigen processing.Q34009896
Proteasomes in the archaea: from structure to functionQ34019664
???Q64770076
Proteasome degradation: enter the substrateQ44628364
Purification of beta-hydroxy-beta-methylglutaryl-coenzyme A reductase from yeastQ44689106
Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophagesQ47875817
Food Restriction Enhances the Proteolytic Capacity of the Aging Rat LiverQ48939192
Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cellsQ49011862
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ67685401
A multicatalytic protease complex from pituitary that forms enkephalin and enkephalin containing peptidesQ70195018
Liver adenosine triphosphate (ATP) in hypoxia and hemorrhagic shockQ70456998
Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharideQ71120614
Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cellsQ71973366
Release of a macromolecular protein component from human erythrocyte ghostsQ72045895
Cardiac and skeletal muscle metabolic energy stores in hemorrhagic shockQ72340179
The isolation and purification of a macromolecular protein component from the human erythrocyte ghostQ72530075
Changes in adenine nucleotides during hemorrhagic shock and reperfusionQ73048861
New evidence for beneficial effects of statins unrelated to lipid loweringQ73366268
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylationQ73596405
The use of insulin and glucose during resuscitation from hemorrhagic shock increases hepatic ATPQ74008190
Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12Q74477183
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathwayQ74485172
Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL/6 ApoE-deficient miceQ74587821
An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitroQ77754902
Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsisQ78117684
Mammalian Toll-like receptorsQ78699977
Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why?Q34214158
Caretaker or undertaker? The role of the proteasome in agingQ34224564
Cation-sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary enzymeQ34269288
Proteasome inhibitors: from research tools to drug candidatesQ34341985
Proteasomes and proteasome inhibition in the central nervous systemQ34346616
Detecting and responding to hypoxiaQ34506939
Transferring substrates to the 26S proteasome.Q35040957
Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cellsQ35136467
The Toll-IL-1 receptor adaptor family grows to five members.Q35155932
Diphosphoryl lipid A from Rhodobacter sphaeroides inhibits complexes that form in vitro between lipopolysaccharide (LPS)-binding protein, soluble CD14, and spectrally pure LPS.Q35551940
Hemorrahagic shock: a new look at an old problemQ35577111
Pathogenesis of sepsis: current concepts and emerging therapiesQ35577116
TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expressionQ35679602
Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscleQ35824460
The protective action of allopurinol in an experimental model of haemorrhagic shock and reperfusionQ35887329
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated miceQ36352474
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cellsQ36370326
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesionQ37353803
Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane proteinQ37383994
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophagesQ37510351
HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cellsQ38358814
Kinetic analysis of the individual reductive steps catalyzed by β-hydroxy-β-methylglutaryl-coenzyme A reductase obtained from yeastQ39111871
Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27Q39573099
Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin).Q39594721
Cachectin: more than a tumor necrosis factorQ39755392
Proteasomes: protein degradation machines of the cellQ40646488
The effects of lovastatin on proteasome activities in highly purified rabbit 20 S proteasome preparations and mouse MC3T3-E1 osteoblastic cellsQ40707999
Diphosphoryl lipid A from Rhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide in RAW 264.7 cellsQ40797218
Lovastatin and simvastatin are modulators of the proteasome.Q40841557
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ40858049
Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cellsQ40879729
Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylationQ40884666
Possible involvement of proteasome inhibition in aging: implications for oxidative stress.Q40895097
Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formationQ40906263
Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.Q40925745
Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages.Q41195715
The ubiquitin-mediated proteolytic pathway as a therapeutic areaQ41340821
Early clinical experience with the novel proteasome inhibitor PS-519.Q42138557
Proteasome inhibition leads to NF-kappaB-independent IL-8 transactivation in human endothelial cells through induction of AP-1.Q42525527
The cellular chamber of doom.Q43513552
Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusionQ43619451
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shockQ44028476
Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in ratsQ44031120
Depletion and restoration of tissue ATP in hemorrhagic shockQ44356614
Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemiaQ44470430
P433issue3
P921main subjectmacrophageQ184204
P304page(s)243-260
P577publication date2005-01-01
P1433published inImmunologic ResearchQ15754981
P1476titleThe proteasome: a central regulator of inflammation and macrophage function
P478volume31

Reverse relations

cites work (P2860)
Q37151518A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model
Q36984148A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes
Q45969598A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.
Q34626385A systems-based approach to analyse the host response in murine lung macrophages challenged with respiratory syncytial virus
Q33744734Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Q37400540Anti-inflammatory Effect of Perilla frutescens (L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages
Q39717275Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.
Q34039823Cytochalasin B modulates macrophage-mediated inflammatory responses
Q47132046Defective Protein Catabolism in Atherosclerotic Vascular Inflammation
Q34024993Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes
Q35905393Down-regulation of Stathmin Is Required for the Phenotypic Changes and Classical Activation of Macrophages
Q39538314Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells
Q38064967Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development
Q37788639Genetics of childhood-onset inflammatory bowel disease
Q54472829Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4.
Q34534191HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivo
Q36790665Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes
Q34805596Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment
Q41612495Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice
Q64985159Inhibition of Proteasome Activity Upregulates IL-6 Expression in RPE Cells through the Activation of P38 MAPKs.
Q36086859Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
Q35704170Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin
Q41302166Interaction of Proteasomes and Complement C3, Assay of Antisecretory Factor in Blood
Q39566694LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites
Q38496963Lipid A-Mediated Tolerance and Cancer Therapy
Q37098578Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells
Q40009131MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: involvement of nuclear factor-kappaB and activator protein-1.
Q34703669Multi-omic data integration links deleted in breast cancer 1 (DBC1) degradation to chromatin remodeling in inflammatory response
Q35941896Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity
Q37364057Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects
Q53720678Of Mice and Men: Proteasome's Role in LPS-Induced Inflammation and Tolerance.
Q39978747Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.
Q34048268Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response†.
Q37422527Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells
Q36301130Proteasome protease mediated regulation of cytokine induction and inflammation
Q39562508Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation.
Q90225030Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms
Q33679929Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease
Q35820457Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition
Q35505150Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
Q35539348The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages
Q36469148The pivotal role of TBK1 in inflammatory responses mediated by macrophages
Q34143900The proteasome regulates bacterial CpG DNA-induced signaling pathways in murine macrophages
Q37868923The role of immunity in Huntington's disease
Q40080281The role of the immunoproteasome in interferon-γ-mediated microglial activation
Q34468200Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice
Q90382694δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients

Search more.