Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

scientific article

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2012PNAS..10912105X
P356DOI10.1073/PNAS.1120914109
P932PMC publication ID3409739
P698PubMed publication ID22773818
P5875ResearchGate publication ID228447290

P50authorJohanna M SweereQ57062054
Raymond A SobelQ87841746
Vijay KuchrooQ87889159
Francisco J. QuintanaQ88364866
Chuan WuQ57017609
P2093author name stringSheng Xiao
Ada Yeste
Joseph V Bonventre
Takaharu Ichimura
Chen Zhu
Craig R Brooks
Sonia Petecka
P2860cites workImmunosuppressive effects of apoptotic cellsQ59060221
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4Q24523091
The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptorQ24523454
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.Q24657708
Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine BindsQ27649330
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene familyQ28207890
Immunology: hepatitis A virus link to atopic diseaseQ28208230
TIM-1 induces T cell activation and inhibits the development of peripheral toleranceQ28241921
TIM-1, a novel allergy and asthma susceptibility geneQ28249050
Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environmentQ28305029
Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cellsQ28573345
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injuryQ28591447
Tim-2 regulates T helper type 2 responses and autoimmunityQ33220331
Identification of Tim4 as a phosphatidylserine receptorQ33303850
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr miceQ34080154
TIM-4 expressed on APCs induces T cell expansion and survivalQ34170292
Regulatory T cells and Foxp3Q34177949
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humansQ34627078
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneysQ34892862
Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cellsQ35084636
The TIM gene family: emerging roles in immunity and diseaseQ35140798
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in miceQ35187089
Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin-and mucin-like regionsQ35218397
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cellsQ35956837
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector functionQ36229490
TIM family of genes in immunity and toleranceQ36580104
The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signalsQ37069155
Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunityQ37072801
TIM gene family and their role in atopic diseasesQ37252316
Regulatory B cells as inhibitors of immune responses and inflammationQ37256986
Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cellsQ37366061
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunityQ37763998
Novel roles for TIM-1 in immunity and infectionQ37930745
Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response.Q39867601
Tim1 and Tim3 are not essential for experimental allergic asthmaQ42097415
New roles for TIM family members in immune regulationQ44470505
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.Q51818425
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectcell functionQ95674809
P304page(s)12105-12110
P577publication date2012-07-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDefect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice
P478volume109

Reverse relations

cites work (P2860)
Q57976581A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses
Q35235319Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis
Q101038988Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Q41003256Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice
Q64279721Association of interleukin-27 gene polymorphisms with susceptibility to HIV infection and disease progression
Q90599409Biological Function and Immunotherapy Utilizing Phosphatidylserine-based Nanoparticles
Q39345723CD19+ Tim-1+ B cells are decreased and negatively correlated with disease severity in Myasthenia Gravis patients
Q89908654CD19+CD24hiCD38hi B Cell Dysfunction in Primary Biliary Cholangitis
Q47639693CD27+TIM-1+ memory B cells promoted the development of Foxp3+ Tregs and were associated with better survival in acute respiratory distress syndrome
Q30409350Characterizing functional domains for TIM-mediated enveloped virus entry
Q37128891Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.
Q28397407Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity
Q38170793Contributions of B cells to lupus pathogenesis
Q55019070Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis.
Q34004649Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus
Q42231946Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice
Q38742256Expression of Tim-1 in primary CNS lymphoma
Q90019854Follicular cytotoxic CD8 T cells present high cytokine expression, and are more susceptible to Breg-mediated suppression in non-small cell lung cancer
Q49318689Galectin-1 is required for the regulatory function of B cells.
Q34138195Generation and identification of tumor-evoked regulatory B cells
Q35106912IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses.
Q40184422IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo
Q26740298Immune Regulation and Antitumor Effect of TIM-1
Q49805205Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells.
Q39215639Immune checkpoint proteins: exploring their therapeutic potential to regulate atherosclerosis
Q35849866Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy
Q33793070Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells
Q53327428Introduction: Regulatory B Cell Special Issue-making all the pieces fit.
Q36148385KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation
Q35409103KIM-1-mediated phagocytosis reduces acute injury to the kidney
Q42923626KIM-1/TIM-1 in proximal tubular cell immune response
Q100387986KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney
Q90329271Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies
Q51758759Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response.
Q59326875Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy
Q91012553MicroRNA-146a-deficient mice develop immune complex glomerulonephritis
Q38636569Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy
Q36011177New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome
Q27015034Phosphatidylserine receptors: enhancers of enveloped virus entry and infection
Q39084950Potential importance of B cells in aging and aging-associated neurodegenerative diseases
Q42276429Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis
Q39160359Regulatory B cells: Phenotype, function and role in transplantation
Q38233691Regulatory functions of B cells in allergic diseases
Q35979565Renal Transplant Recipients Treated with Calcineurin-Inhibitors Lack Circulating Immature Transitional CD19+CD24hiCD38hi Regulatory B-Lymphocytes
Q35726920Retracted: Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer
Q26824451Role of B cells in tolerance induction
Q38468652Signals controlling the development and activity of regulatory B-lineage cells
Q37067433T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death
Q40412394TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance.
Q37595691TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients
Q33788812TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity
Q27314979TIM-1 signaling is required for maintenance and induction of regulatory B cells
Q26753825The clearance of dying cells: table for two
Q38526835The expanding family of regulatory B cells.
Q35137217Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation
Q57177957Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management
Q40273988What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?
Q48578964miR-21 silencing ameliorates experimental autoimmune encephalomyelitis by promoting the differentiation of IL-10-producing B cells

Search more.