5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymerase

scientific article

5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymerase is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKW812
P932PMC publication ID5175357
P698PubMed publication ID27651460

P2093author name stringAndreas Marx
Claudia Huber
Janina von Watzdorf
P2860cites workThymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNAQ24305161
Bisulfite genomic sequencing: systematic investigation of critical experimental parametersQ24555629
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strandsQ24562877
The methylomes of six bacteriaQ24598577
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
REBASE--restriction enzymes and methylasesQ24633166
Human DNA methylomes at base resolution show widespread epigenomic differencesQ24633677
Epigenetic gene regulation in the bacterial worldQ24669987
Chemical discrimination between dC and 5MedC via their hydroxylamine adductsQ27664253
Structures of KOD and 9°N DNA polymerases complexed with primer template duplexQ27684750
DNA methylation analysis by pyrosequencingQ81247006
Synthesis and stability of phosphate modified ATP analoguesQ85248763
DNA methylation profiling in the clinic: applications and challengesQ38040319
Dynamics of bacteriophage T4 DNA polymerase function: identification of amino acid residues that affect switching between polymerase and 3' --> 5' exonuclease activitiesQ38289146
Direct sensing of 5-methylcytosine by polymerase chain reactionQ41125239
DNA polymerase 3'→5' exonuclease activity: Different roles of the beta hairpin structure in family-B DNA polymerasesQ41262109
6-Substituted 2-Aminopurine-2'-deoxyribonucleoside 5'-Triphosphates that Trace Cytosine MethylationQ41672807
Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair terminiQ41787453
Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5-MethylcytosineQ42221071
Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracilQ43244988
Structural basis for uracil recognition by archaeal family B DNA polymerasesQ44204271
DNA polymerase insertion fidelity. Gel assay for site-specific kineticsQ46103467
SeqA: a negative modulator of replication initiation in E. coliQ48082693
Timing and targeting: the biological functions of Dam methylation in E. coli.Q53041382
Cytosines adjacent to methylated CpG sites can be partially resistant to conversion in genomic bisulfite sequencing leading to methylation artifacts.Q53960299
The fundamental role of epigenetic events in cancerQ56421597
Evolving a thermostable DNA polymerase that amplifies from highly damaged templatesQ56898603
Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffoldQ56898729
Using 2-Aminopurine Fluorescence and Mutational Analysis to Demonstrate an Active Role of Bacteriophage T4 DNA Polymerase in Strand Separation Required for 3′ → 5′-Exonuclease ActivityQ62590161
Structural basis for processive DNA synthesis by yeast DNA polymerase ɛQ27687755
Worms gang up on bacteriaQ27860588
Induced pluripotent stem cell lines derived from human somatic cellsQ27860597
Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B familyQ28273546
Real-time DNA sequencing from single polymerase moleculesQ28301519
Identification of a mutant DNA polymerase delta in Saccharomyces cerevisiae with an antimutator phenotype for frameshift mutationsQ28364152
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanismQ28369244
The role of DNA methylation in mammalian epigeneticsQ29617979
Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidationQ30456249
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencingQ30470204
Comparison between DNA melting thermodynamics and DNA polymerase fidelityQ33642760
YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.Q33842803
Direct detection of DNA methylation during single-molecule, real-time sequencingQ33888756
Reaction of sodium bisulfite with uracil, cytosine, and their derivativesQ34053845
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancerQ34153611
DNA methylation and the frequency of CpG in animal DNA.Q34252001
5-Methylcytosine in eukaryotic DNA.Q34252459
A comparison of the fidelity of copying 5-methylcytosine and cytosine at a defined DNA template siteQ35930480
Non-CG Methylation in the Human Genome.Q36509778
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.Q36659158
Novel inhibition of archaeal family-D DNA polymerase by uracil.Q36769436
Genomic patterns of DNA methylation: targets and function of an epigenetic markQ36805024
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.Q36967574
Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies.Q37014723
Restriction and modification systemsQ37041891
Role of excess inorganic pyrophosphate in primer-extension genotyping assaysQ37496247
Mammalian cytosine methylation at a glance.Q37573260
Engineered DNA Polymerases in BiotechnologyQ37791510
Cancer epigenomics: beyond genomicsQ37991917
HLA DNA typing: past, present, and futureQ38014961
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)9881-9890
P577publication date2016-09-19
P1433published inNucleic Acids ResearchQ135122
P1476title5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymerase
P478volume44

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cites work (P2860)
Q90022362Engineering Polymerases for New Functions
Q41626623Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase
Q47370308Engineering of a DNA Polymerase for Direct m6 A Sequencing.
Q90243273Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
Q42215235Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering
Q61444311Identification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library
Q41496563Variants of sequence family B Thermococcus kodakaraensis DNA polymerase with increased mismatch extension selectivity