Engineering of a DNA Polymerase for Direct m6 A Sequencing.

scientific article published on 8 November 2017

Engineering of a DNA Polymerase for Direct m6 A Sequencing. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ANIE.201710209
P932PMC publication ID5768020
P698PubMed publication ID29115744

P50authorAndreas MarxQ30251171
Mark HelmQ57236201
Virginie MarchandQ58799405
P2093author name stringYuri Motorin
Stephan Werner
Martina Adam
Joos Aschenbrenner
P2860cites workAn in vitro system for accurate methylation of internal adenosine residues in messenger RNAQ67962845
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seqQ24320240
N(6)-methyladenosine Modulates Messenger RNA Translation EfficiencyQ24337939
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cellsQ24563918
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codonsQ24598126
Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical LegolandQ26849515
Replication through an abasic DNA lesion: structural basis for adenine selectivityQ27660600
Structure and function of an RNA-reading thermostable DNA polymeraseQ27687037
Nuclear m(6)A Reader YTHDC1 Regulates mRNA SplicingQ28114974
MODOMICS: a database of RNA modification pathways--2013 updateQ28278502
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiationQ28511267
RNA-methylation-dependent RNA processing controls the speed of the circadian clockQ28591141
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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.Q29616842
Traces of post-transcriptional RNA modifications in deep sequencing dataQ33827523
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNAQ34378909
Coming of age: ten years of next-generation sequencing technologiesQ34526801
Directed evolution of DNA polymerases: construction and screening of DNA polymerase mutant librariesQ34803084
High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencingQ35413587
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptomeQ35804751
High-throughput sequencing for 1-methyladenosine (m(1)A) mapping in RNA.Q35938513
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotidesQ36000833
5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymeraseQ36139113
The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependentQ36676585
Direct and site-specific quantification of RNA 2'-O-methylation by PCR with an engineered DNA polymeraseQ36870545
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Post-transcriptional gene regulation by mRNA modifications.Q37515917
Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA.Q37528573
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity.Q38362195
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.Q38712170
RNA modifications: what have we learned and where are we headed?Q38824134
Detecting RNA modifications in the epitranscriptome: predict and validateQ39143334
CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing ProfilesQ39195869
A high-throughput assay for the comprehensive profiling of DNA ligase fidelity.Q41986633
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transitionQ42130806
Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymesQ42544686
The 3D rRNA modification maps database: with interactive tools for ribosome analysisQ43032876
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelityQ44945167
The emerging biology of RNA post-transcriptional modificationsQ45849005
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)417-421
P577publication date2017-12-07
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleEngineering of a DNA Polymerase for Direct m6 A Sequencing
P478volume57

Reverse relations

cites work (P2860)
Q64105802A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
Q62485343Colocalization of mA and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine -Methylation
Q90266653Detection of N6‑methyladenosine modification residues (Review)
Q55261655Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.
Q58762398Emerging approaches for detection of methylation sites in RNA
Q90022362Engineering Polymerases for New Functions
Q90681486Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures
Q61444311Identification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library
Q89870636Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes
Q61799430Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies
Q96683588N6-methyladenosine (m6A) methylation in ischemia-reperfusion injury
Q90101544Reading, writing and erasing mRNA methylation
Q90025519Sequencing-based methods for detection and quantitation of ribose methylations in RNA
Q66678738Significant epitranscriptomes in heterogeneous cancer

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