Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.

scientific article published on 22 May 2018

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. is …
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scholarly articleQ13442814
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P6179Dimensions Publication ID1104145317
P356DOI10.1038/S41422-018-0040-8
P932PMC publication ID5993786
P698PubMed publication ID29789545

P50authorYun-Gui YangQ68692610
P2093author name stringYing Yang
Yu-Sheng Chen
Phillip J Hsu
P2860cites workAdenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental DefectsQ21129219
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTOQ24293481
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseQ24299948
The YTH domain is a novel RNA binding domainQ24300052
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sitesQ24300072
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domainQ24304328
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertilityQ24304362
N6-methyladenosine-dependent regulation of messenger RNA stabilityQ24310545
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOQ24310886
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylationQ24311871
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferaseQ24315962
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferaseQ24318728
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactionsQ24320088
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seqQ24320240
N6-methyladenosine marks primary microRNAs for processingQ24323516
Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycleQ24337790
N(6)-methyladenosine Modulates Messenger RNA Translation EfficiencyQ24337939
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 geneQ24537653
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cellsQ24563918
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codonsQ24598126
Sequence specificity of the human mRNA N6-adenosine methylase in vitroQ24599892
Mapping of N6-methyladenosine residues in bovine prolactin mRNAQ24607526
Yeast targets for mRNA methylationQ24610628
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophyQ24617996
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolutionQ24630078
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityQ24650037
MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factorQ24650812
Dynamic integration of splicing within gene regulatory pathwaysQ26852632
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cellsQ27303707
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complexQ27709350
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosisQ27930684
IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiaeQ27932777
RNA methylation by the MIS complex regulates a cell fate decision in yeastQ27936524
5' UTR m(6)A Promotes Cap-Independent TranslationQ28114851
Nuclear m(6)A Reader YTHDC1 Regulates mRNA SplicingQ28114974
Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcriptsQ28115666
The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNAQ28116053
Structural Basis for Cooperative Function of Mettl3 and Mettl14 MethyltransferasesQ28117995
Dynamic m(6)A mRNA methylation directs translational control of heat shock responseQ28118495
HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing EventsQ28118781
The spliceosome: design principles of a dynamic RNP machineQ28131809
Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNAQ28210505
Wheat embryo ribonucleates. XIII. Methyl-substituted nucleoside constituents and 5′-terminal dinucleotide sequences in bulk poly(A)-rich RNA from imbibing wheat embryosQ28245427
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulationQ28267771
Variation in FTO contributes to childhood obesity and severe adult obesityQ28301922
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiationQ28511267
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cellsQ28585513
RNA-methylation-dependent RNA processing controls the speed of the circadian clockQ28591141
Cytoplasmic m6A reader YTHDF3 promotes mRNA translationQ29465772
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.Q29465801
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsQ29614593
Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblastsQ30452313
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron RetentionQ32884542
Meioc maintains an extended meiotic prophase I in miceQ33579982
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity proteinQ33741052
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotencyQ39038754
Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expressionQ39139864
Alternative splicing as a regulator of development and tissue identity.Q39295240
Dynamic RNA Modifications in Gene Expression RegulationQ39378718
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.Q39508782
Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in ZebrafishQ39909322
Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex.Q51146557
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.Q51236778
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.Q52352943
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase.Q52354903
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.Q52357020
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.Q52366303
Methyl labeling of HeLa cell hnRNA: a comparison with mRNA.Q54616315
Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cellsQ67044392
Post-transcriptional Modifications of Oat Coleoptile Ribonucleic Acids. 5'-Terminal Capping and Methylation of Internal Nucleosides in Poly(A)-Rich RNAQ72607739
N6-methyladenosine–encoded epitranscriptomicsQ87219496
Dynamic m 6 A modification and its emerging regulatory role in mRNA splicingQ106463675
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.Q33865334
The m6A pathway facilitates sex determination in Drosophila.Q33882267
m(6)A RNA methylation promotes XIST-mediated transcriptional repressionQ33902260
Reversible methylation of m6Am in the 5' cap controls mRNA stabilityQ33909841
The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA.Q33924207
Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferaseQ34152368
Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.Q34160093
Landscape and variation of RNA secondary structure across the human transcriptomeQ34400880
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesisQ34448805
Mechanisms and Regulation of Alternative Pre-mRNA SplicingQ34467642
N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamicsQ34508439
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer CellsQ34523745
Methylated, blocked 5 termini in HeLa cell mRNAQ35079459
Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cellsQ35080272
Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesisQ35202750
WTAP is a novel oncogenic protein in acute myeloid leukemiaQ35206435
High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencingQ35413587
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modificationQ35511241
Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin TreatmentQ35694644
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptomeQ35804751
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy BrainQ35984230
Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteinsQ36193050
Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicingQ36470502
N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein BindingQ36653832
Distal Alternative Last Exons Localize mRNAs to Neural ProjectionsQ36703465
N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA.Q36722908
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.Q36856390
YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complexQ37222906
Post-transcriptional gene regulation by mRNA modifications.Q37515917
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cellsQ37662078
FTO and obesity: mechanisms of associationQ38195783
m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathwaysQ38632272
Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic ReplicationQ38700916
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation ProgramQ38710467
The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleusQ40068214
N6-adenosine methylation in mRNA: substrate specificity and enzyme complexityQ40524703
m(6)A: Signaling for mRNA splicingQ41032628
Structural insights into the molecular mechanism of the m(6)A writer complexQ41093229
Structural imprints in vivo decode RNA regulatory mechanismsQ41177072
The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte CompetenceQ41666796
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesisQ41791644
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transitionQ42130806
Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and ReprogrammingQ42134417
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.Q42380468
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.Q42425833
Temporal Control of Mammalian Cortical Neurogenesis by m(6)A MethylationQ42425840
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation.Q42425844
Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancerQ42945885
Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acidQ43835706
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Q45067620
The emerging biology of RNA post-transcriptional modificationsQ45849005
m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptomeQ46049894
5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C readerQ46550226
m6A modulates neuronal functions and sex determination in DrosophilaQ47071868
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination.Q47072159
m6A modulates haematopoietic stem and progenitor cell specificationQ47073270
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processingQ47128487
The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germlineQ47169510
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A ModificationQ47207720
Outlier detection for improved differential splicing quantification from RNA-Seq experiments with replicates.Q47252957
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cellsQ47253085
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.Q47284426
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.Q47289701
Engineering of a DNA Polymerase for Direct m6 A Sequencing.Q47370308
RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome.Q47400144
Reading m6A in the Transcriptome: m6A-Binding ProteinsQ47440542
Highly parallel direct RNA sequencing on an array of nanopores.Q47553619
Role of N6-methyladenosine modification in cancerQ47567064
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.Q47583443
Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.Q47609295
Endothelial-specific m(6)A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling.Q47834702
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.Q47860359
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1.Q48147488
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.Q48185934
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Q50422081
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjecttranscriptomeQ252857
P304page(s)616-624
P577publication date2018-05-22
2018-06-01
P1433published inCell ResearchQ1524018
P1476titleDynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
P478volume28