Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation

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Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..10912692L
P356DOI10.1073/PNAS.1207816109
P932PMC publication ID3411985
P698PubMed publication ID22802632
P5875ResearchGate publication ID229157225

P50authorGinger Lohr MilneQ42289929
P2093author name stringTao Liu
Wei Xing
Chunli Feng
Joshua A Boyce
Tanya M Laidlaw
Shiliang Shen
P2860cites workMolecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesisQ22254717
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Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthmaQ28195990
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansionQ28509130
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregationQ30442280
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Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienesQ34681509
Effect of AA-2414, a thromboxane A2 receptor antagonist, on airway inflammation in subjects with asthmaQ77846743
Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmaticsQ77950275
Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kineticsQ79330395
Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammationQ80967764
PGE1 and PGE2 modify platelet function through different prostanoid receptorsQ82542422
Function of prostanoid receptors: studies on knockout miceQ34998028
Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.Q35029268
The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammationQ35119060
Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytesQ35130535
Prostaglandin E(2) produced by the lung augments the effector phase of allergic inflammationQ35884115
Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1.Q36229169
Pulmonary arterial remodeling induced by a Th2 immune responseQ36502869
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Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammationQ37040964
Prostanoids in health and diseaseQ37354582
Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profileQ42458436
Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patientsQ42483573
NSAIDs and risk of lower gastrointestinal bleedingQ42967157
Prostaglandin E2 and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammationQ43246933
Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors.Q43264491
Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathwayQ44002240
Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanismQ44064944
The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat.Q44147247
Receptors and pathways mediating the effects of prostaglandin E2 on airway toneQ44346690
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunityQ44460666
Effect of an inhaled thromboxane mimetic (U46619) on airway function in human subjectsQ44468964
Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthmaQ46363432
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.Q46418233
Prostaglandin E2 protects lower airways against bronchoconstrictionQ46661216
Analgesic effectiveness of celecoxib and diclofenac in patients with osteoarthritis of the hip requiring joint replacement surgery: a 12-week, multicenter, randomized, double-blind, parallel-group, double-dummy, noninferiority studyQ46700105
Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanismQ46769476
Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitisQ46931463
Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cellsQ47901464
Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthmaQ48020876
Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery.Q54599017
Reduced expression of COXs and production of prostaglandin E2 in patients with nasal polyps with or without aspirin-intolerant asthmaQ62520456
BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmaticsQ71056892
Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthmaQ72964940
Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophagesQ73038797
Thromboxane A2 induces cell signaling but requires platelet-derived growth factor to act as a mitogenQ73094032
Interaction of PGH synthase isozymes-1 and -2 with nonsteroidal anti-inflammatory drugsQ74454826
A genetic approach for studying the role of thromboxane A2 in the kidneyQ77295835
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cellsQ77530803
Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmaticsQ77653813
Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammationQ77747398
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
prostaglandin E2Q416554
Dermatophagoides pteronyssinusQ4573411
P1104number of pages6
P304page(s)12692-12697
P577publication date2012-07-16
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleProstaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation
P478volume109

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