Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells

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Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.3648
P932PMC publication ID4599254
P698PubMed publication ID26202747
P5875ResearchGate publication ID280390988

P2093author name stringYan Wang
Ze-Hong Miao
Jia-Xin Li
Ying-Qing Wang
P2860cites workIncreased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolideQ24302071
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active componentsQ26825621
Newly discovered angiogenesis inhibitors and their mechanisms of actionQ26998498
Detecting metabolites of different transition metal-lithospermate B complexes after intravenous injection in ratsQ28389748
Purification and characterization of hypoxia-inducible factor 1Q28678375
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxiaQ30399006
Therapeutic modulators of STAT signalling for human diseasesQ33684732
The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesisQ34316079
A signal transducer and activator of transcription 3·Nuclear Factor κB (Stat3·NFκB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-αQ34396993
Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis inductionQ35128174
Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibitionQ35832271
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injuryQ36179559
Marine-derived angiogenesis inhibitors for cancer therapyQ36994177
Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agentQ37230783
MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.Q37293931
Tanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networksQ37357080
Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.Q37827709
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanismsQ37978125
Interleukin-6: an angiogenic target in solid tumours.Q38136860
Inflammation amplifier, a new paradigm in cancer biologyQ38173304
Revisiting STAT3 signalling in cancer: new and unexpected biological functionsQ38262473
Transcription factor c-Jun activation represses mdr-1 gene expression.Q38351649
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.Q39290009
c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional mannerQ39801995
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathwaysQ40399370
Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene.Q40460041
Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion moleculesQ46513225
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model.Q54319778
Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitroQ67665202
Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trialQ88123697
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
phosphorylationQ242736
tumor angiogenesisQ110495869
P304page(s)16031-16042
P577publication date2015-06-01
P1433published inOncotargetQ1573155
P1476titleTanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells
P478volume6

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cites work (P2860)
Q36332681A promising "TRAIL" of tanshinones for cancer therapy
Q36958382BRAF kinase inhibitor exerts anti-tumor activity against breast cancer cells via inhibition of FGFR2.
Q47148987Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells
Q39216218Diterpenes and Their Derivatives as Potential Anticancer Agents
Q42512424Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
Q54123249Qiliqiangxin attenuates hypoxia-induced injury in primary rat cardiac microvascular endothelial cells via promoting HIF-1α-dependent glycolysis.
Q52561276Salvia miltiorrhizaBurge (Danshen): A golden herbal medicine in cardiovascular therapeutics.
Q91779192Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway
Q50129481Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo
Q64093119Tanshinones, Critical Pharmacological Components in
Q42025605Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.
Q88883453Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine
Q37034926The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4
Q42366665The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis.
Q57813339YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells

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