Consequences of splice variation on Secretin family G protein-coupled receptor function

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Consequences of splice variation on Secretin family G protein-coupled receptor function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01571.X
P932PMC publication ID3415641
P698PubMed publication ID21718310
P5875ResearchGate publication ID51456810

P50authorArthur ChristopoulosQ18977850
Denise WoottenQ43294588
Sebastian FurnessQ57072112
Patrick M. SextonQ39936838
P2093author name stringPatrick M Sexton
Sebastian G B Furness
P2860cites workA general definition and nomenclature for alternative splicing eventsQ21563499
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotypeQ22122487
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RSQ24304303
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Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell lineQ24337451
Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligandQ27644056
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptorQ27647464
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domainQ27649890
Molecular recognition of parathyroid hormone by its G protein-coupled receptorQ27650193
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonismQ27664362
Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptorQ28115064
N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinantsQ28139403
In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptorQ28201065
Novel receptor partners and function of receptor activity-modifying proteinsQ28215813
Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cellsQ40536196
Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivityQ40663308
Human CRF2 alpha and beta splice variants: pharmacological characterization using radioligand binding and a luciferase gene expression assayQ40958147
Molecular cloning of two receptors from rat brain with high affinity for salmon calcitoninQ41542401
N-terminal truncation of salmon calcitonin leads to calcitonin antagonists. Structure activity relationship of N-terminally truncated salmon calcitonin fragments in vitro and in vivoQ41607432
Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptorQ41883095
Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinomaQ44138569
A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificityQ44336537
8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivoQ46437996
Dimerization of corticotropin-releasing factor receptor type 1 is not coupled to ligand bindingQ46880025
Chimeric human calcitonin and glucagon receptors reveal two dissociable calcitonin interaction sitesQ48075434
Function of the rat calcitonin receptors, C1a and C1b, expressed in Xenopus oocytes.Q48946039
Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor.Q51795077
Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop.Q51798125
Molecular Identification and Analysis of a Novel Human Corticotropin-Releasing Factor (CRF) Receptor: The CRF2 ReceptorQ56601763
Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptorQ56607577
A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2Q69838435
A fragment of vasoactive intestinal peptide, VIP(10-28), is an antagonist of VIP in the colon carcinoma cell line, HT29Q70159024
Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcriptQ71523035
Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interactionQ71742566
Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transductionQ72019750
Sustained activation of Erk1/2 MAPK and cell growth suppression by the insert-negative, but not the insert-positive isoform of the human calcitonin receptorQ73040317
Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptorQ73370227
High potency antagonists of the pancreatic glucagon-like peptide-1 receptorQ73596177
The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide patternQ74061883
Fish calcitonin receptor has novel featuresQ80730274
Headless splice variant acting as dominant negative calcitonin receptorQ81151571
Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptorQ28296331
Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptorQ28300089
Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptorsQ28303314
Differential signal transduction by five splice variants of the PACAP receptorQ28566746
Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the ratQ28579516
Identification of brain isoforms of the rat calcitonin receptorQ28580007
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprintsQ29547321
Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling durinQ33181839
Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20--emerging role of soluble isoforms.Q33623010
A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activityQ33850519
Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptorQ33953071
PAC1hop receptor activation facilitates catecholamine secretion selectively through 2-APB-sensitive Ca(2+) channels in PC12 cellsQ34044166
Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerizationQ34079450
Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expressionQ34095571
The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretionQ34280490
A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacologyQ34315166
Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.Q34384700
Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRsQ34624051
A naturally occurring isoform inhibits parathyroid hormone receptor trafficking and signalingQ35229970
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.Q35454522
The alternatively spliced type II corticotropin-releasing factor receptor, stably expressed in LLCPK-1 cells, is not well coupled to the G protein(s).Q36688775
Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptorQ36700621
Differential signaling and immediate-early gene activation by four splice variants of the human pituitary adenylate cyclase-activating polypeptide receptor (hPACAP-R).Q36841864
CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulationsQ37032694
Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptorQ37177027
Soluble corticotropin-releasing hormone receptor 2alpha splice variant is efficiently translated but not trafficked for secretionQ37328849
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptorQ37511744
Emerging role of alternative splicing of CRF1 receptor in CRF signaling.Q37710423
Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinomaQ38292254
Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d.Q39943150
Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1beta and response to PKC phosphorylation.Q40072646
Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylationQ40234783
Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP.Q40361764
Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor.Q40467495
Differential signal transduction by six splice variants of the pituitary adenylate cyclase-activating peptide (PACAP) receptor.Q40530544
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)98-109
P577publication date2012-05-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleConsequences of splice variation on Secretin family G protein-coupled receptor function
P478volume166

Reverse relations

cites work (P2860)
Q36860090Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity
Q39293507Amylin
Q48198655CGRP and its receptors
Q39146023Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
Q38696170Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand.
Q90700664Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin
Q37635255Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.
Q55709770Neuropeptide G Protein-Coupled Receptors as Oncotargets.
Q38274844PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells
Q36153216Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.
Q41598194Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Q48034068Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine
Q36629283Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) function
Q43238779Secretin family (Class B) G protein-coupled receptors - from molecular to clinical perspectives
Q90913018The role of GPCRs in bone diseases and dysfunctions
Q36834005Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

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