CGRP and its receptors

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CGRP and its receptors is …
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scholarly articleQ13442814

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P356DOI10.1111/HEAD.13064
P698PubMed publication ID28233915

P50authorDebbie HayQ37829061
Christopher WalkerQ37829052
P2860cites workAn amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3Q22009905
Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recyclingQ22254563
Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteinsQ24304926
Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterizationQ24319098
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptorQ24323946
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Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestinQ28215231
Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculatureQ28215715
Calcitonin gene-related peptide: physiology and pathophysiologyQ28249298
Vasoactive peptide release in the extracerebral circulation of humans during migraine headacheQ28265001
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytesQ28267757
Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1Q28289037
Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the ratQ28567431
Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor geneQ28592688
Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysisQ30251901
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraineQ30496689
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relateQ30838883
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonistQ33523240
Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat.Q33735468
Molecular aspects and natural source of procalcitoninQ33760702
The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.Q34063180
BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II studyQ34155864
Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trialQ34442510
Neuronal receptor activity-modifying protein 1 promotes energy expenditure in miceQ34718618
Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trialQ34889352
Localization of CGRP receptor components, CGRP, and receptor binding sites in human and rhesus cerebellar cortexQ34897152
Calcitonin gene-related peptide (CGRP): a new target for migraineQ35358428
Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrierQ35477839
Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-levelQ35766483
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.Q35777253
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled ReceptorQ35856565
Consequences of splice variation on Secretin family G protein-coupled receptor functionQ36153242
Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes.Q36153252
Central nervous system binding sites for calcitonin and calcitonin gene-related peptideQ36472901
Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndromeQ36527054
Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) functionQ36629283
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacologyQ36907408
What makes a CGRP2 receptor?Q36916945
CGRP antagonists: unravelling the role of CGRP in migraineQ36982809
CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?Q37337815
Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice.Q37363843
The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugsQ37606694
Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptideQ48375356
Bench to bedside advances in the 21st century for primary headache disorders: migraine treatments for migraine patientsQ48495487
Mapping the calcitonin receptor in human brain stemQ48881416
Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine.Q51328299
Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine.Q51805228
Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial.Q52856000
Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with auraQ57024171
Long-Term Tolerability of Telcagepant for Acute Treatment of Migraine in a Randomized TrialQ57197723
Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraineQ37922799
Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of developmentQ38121126
Monoclonal antibodies for migraine: preventing calcitonin gene-related peptide activityQ38196732
Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraineQ38222817
Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptorQ38287711
Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous systemQ38336498
Calcitonin gene-related peptide and migraineQ38427034
Amylin: Pharmacology, Physiology, and Clinical PotentialQ38526856
Targeting CGRP: A New Era for Migraine TreatmentQ38542176
The Journey to Establish CGRP as a Migraine Target: A Retrospective View.Q38561443
Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central SensitizationQ38873658
Wiping Out CGRP: Potential Cardiovascular RisksQ38875005
CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment.Q39193269
In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.Q39221671
Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglionQ39703608
Reply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptorQ39814264
Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat.Q40388098
Model for alternative RNA processing in human calcitonin gene expressionQ40419568
An assessment of the anabolic skeletal actions of the common-region peptides derived from the CGRP and calcitonin prohormonesQ41618159
Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptorsQ41629862
Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.Q41986597
Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.Q42103047
CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissuesQ42115964
Autoradiographic localization of calcitonin gene-related peptide binding sites in human and rat brainsQ42152515
CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.Q42168349
Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteriesQ42882636
Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesityQ42976987
Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglionQ44367679
Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P.Q44639040
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexesQ45251469
Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide ReceptorQ46226305
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptorQ46541484
Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 programQ46698001
Pharmacology of the human CGRP1 receptor in Cos 7 cellsQ46866643
Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b studyQ47644533
Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular systemQ47747629
Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteersQ47953579
CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measuredQ47976301
Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiographyQ48113165
Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiographyQ48271361
P433issue4
P304page(s)625-636
P577publication date2017-02-24
P1433published inHeadacheQ5689497
P1476titleCGRP and its receptors
P478volume57

Reverse relations

cites work (P2860)
Q93024942Aberrant expression of calcitonin gene-related peptide and its correlation with prognosis in severe childhood pneumonia
Q39293507Amylin
Q47979735CGRP Monoclonal Antibodies for Migraine: Rationale and Progress.
Q92337010CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?
Q90221947CGRP in a gene-environment interaction model for depression: effects of antidepressant treatment
Q90321627CGRP-based Migraine Therapeutics: How Might They Work, Why So Safe, and What Next?
Q89462387Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting
Q52309667Cortical spreading depression as a site of origin for migraine: Role of CGRP.
Q89746308Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
Q92826157Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)
Q93170923Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response
Q90700664Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin
Q101121171Optimal treatment strategy of fremanezumab in migraine prevention: a systematic review with network meta-analysis of randomized clinical trials
Q89562323Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine
Q97517034Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain
Q48054533Role of calcitonin gene-related peptide in energy metabolism.
Q96304876The role of erenumab in the treatment of migraine
Q42706186Triptans and CGRP blockade - impact on the cranial vasculature
Q46277281Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.

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