Effect of tyrosine kinase inhibition using imatinib on normal lymphohematopoietic cells.

scientific article

Effect of tyrosine kinase inhibition using imatinib on normal lymphohematopoietic cells. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1196/ANNALS.1349.022
P698PubMed publication ID15958710
P5875ResearchGate publication ID7784004

P50authorSilke AppelQ45423552
P2093author name stringStefan Balabanov
Lothar Kanz
Tim H Brümmendorf
Peter Brossart
P2860cites workLessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaQ24599829
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cellsQ28277030
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaQ29547900
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumorsQ29618610
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemiasQ33343973
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemiaQ34183674
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Dendritic cells in cancer vaccinesQ34430740
Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignanciesQ34564857
Imatinib alone and in combination for chronic myeloid leukemiaQ35058697
Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tQ36365774
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identifiedQ36367631
Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cellsQ36401797
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cellsQ37698653
ARG tyrosine kinase activity is inhibited by STI571.Q40814460
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis.Q41056381
Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xLQ42139163
Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activationQ42834585
Dendritic cell survival and maturation are regulated by different signaling pathways.Q42971737
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitroQ43833442
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemiaQ43899710
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 studyQ43904522
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.Q43977683
Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferationQ43977712
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor betaQ44104227
Effects of imatinib on bone marrow engraftment in syngeneic mice.Q44117835
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatmentQ44308354
Imatinib mesylate (STI571) in preparation for allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions in patients with Philadelphia-positive acute leukemiasQ44319713
Polycythemia vera responds to imatinib mesylateQ44364237
Successful peripheral blood stem cell mobilisation with filgrastim in patients with chronic myeloid leukaemia achieving complete cytogenetic response with imatinib, without increasing disease burden as measured by quantitative real-time PCR.Q44443441
Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitroQ44451881
Imatinib mesylate (Gleevec(TM)) reduces phlebotomy requirements in polycythemia veraQ44452184
The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemiaQ44475743
Inhibitory effect of imatinib on normal progenitor cells in vitroQ44582245
Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitorsQ44582801
Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells.Q44592666
Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivoQ44771609
Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivoQ44853266
Imatinib mesylate (Glivec) pre-treatment does not have a negative effect on outcome of allogenic hematopoietic stem cell transplantation in Philadelphia-positive leukemiasQ45034611
Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell toleranceQ45083314
Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activityQ47685303
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cellsQ59067424
P407language of work or nameEnglishQ1860
P921main subjectimatinibQ177094
P304page(s)168-177
P577publication date2005-06-01
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleEffect of tyrosine kinase inhibition using imatinib on normal lymphohematopoietic cells
P478volume1044

Reverse relations

cites work (P2860)
Q58023940Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability
Q46910193Cytogenetic remissions induced by interferon alpha and imatinib mesylate are immunologically distinct in chronic myeloid leukemia.
Q46755224Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors
Q46900475Hematological side effects of tyrosine kinase inhibition using imatinib
Q46859831Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides
Q39511922Inhibitory effect of soluble platelet-derived growth factor receptor β on intraosseous growth of breast cancer cells in nude mice

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