| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1997PNAS...94.6132K |
| P356 | DOI | 10.1073/PNAS.94.12.6132 |
| P932 | PMC publication ID | 21014 |
| P698 | PubMed publication ID | 9177182 |
| P5875 | ResearchGate publication ID | 14041971 |
| P50 | author | Stephen G. Young | Q1350235 |
| P2093 | author name string | E Kim | |
| S Clarke | |||
| D C MacLaren | |||
| J D Lowenson | |||
| P2860 | cites work | Chemical pathways of peptide degradation. VI. Effect of the primary sequence on the pathways of degradation of aspartyl residues in model hexapeptides | Q72125241 |
| Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms | Q27730887 | ||
| Deamidation in proteins: the crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 | Q27732757 | ||
| Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase | Q27860571 | ||
| The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10 | Q28243120 | ||
| Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase | Q28618551 | ||
| Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein | Q30355031 | ||
| Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation | Q30406473 | ||
| Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase | Q31055356 | ||
| Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins | Q34046554 | ||
| Protein oxidation and aging | Q34243989 | ||
| Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins | Q34616398 | ||
| Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals | Q35941759 | ||
| Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene | Q36802638 | ||
| Covalent modification reactions are marking steps in protein turnover | Q37954451 | ||
| Non-enzymic post-translational modification of proteins in aging. A review | Q38777561 | ||
| Regional and subcellular distribution of protein carboxymethylase in brain and other tissues | Q39098684 | ||
| Roles of turnover and repair of macromolecules and supramolecular structural components | Q40136861 | ||
| Repair, refold, recycle: how bacteria can deal with spontaneous and environmental damage to proteins | Q40369339 | ||
| Protein damage and methylation-mediated repair in the erythrocyte | Q40611236 | ||
| Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomes | Q40865762 | ||
| Genetic analysis of ageing: role of oxidative damage and environmental stresses. | Q41010065 | ||
| Recognition of D-aspartyl residues in polypeptides by the erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis. | Q41114791 | ||
| Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias | Q41269608 | ||
| Modulation of glutamate agonist-induced influx of calcium into neurons by gamma-L-glutamyl and beta-L-aspartyl dipeptides | Q42453143 | ||
| Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells | Q42826036 | ||
| Structural analysis of transcripts for the protein L-isoaspartyl methyltransferase reveals multiple transcription initiation sites and a distinct pattern of expression in mouse testis: identification of a 5'-flanking sequence with promoter activity | Q42834935 | ||
| Effects of amino acid sequence, buffers, and ionic strength on the rate and mechanism of deamidation of asparagine residues in small peptides | Q44947069 | ||
| Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides | Q45085104 | ||
| Spontaneous alterations in the covalent structure of synapsin I during in vitro aging. | Q45953562 | ||
| Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity. | Q45980125 | ||
| Expression and purification of a human recombinant methyltransferase that repairs damaged proteins | Q46099763 | ||
| Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase | Q46220397 | ||
| Automethylation of protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase, a response to enzyme aging | Q47855888 | ||
| High affinity [3H]glutamate uptake systems in normal and audiogenic seizure-susceptible mice | Q48156067 | ||
| Reversible methylation of cytoskeletal and membrane proteins in intact human erythrocytes | Q50938763 | ||
| Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y | Q59055743 | ||
| Methylation of atypical protein aspartyl residues during the stress response of HeLa cells | Q67578425 | ||
| Deamidation via cyclic imide of asparaginyl peptides: dependence on salts, buffers and organic solvents | Q67896365 | ||
| Repair of isopeptide bonds by protein carboxyl O-methyltransferase: seminal ribonuclease as a model system | Q68343063 | ||
| Molecular basis for the accumulation of acidic isozymes of triosephosphate isomerase on aging | Q71011563 | ||
| Gain of glutamines, gain of function? | Q71990830 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 6132-6137 | |
| P577 | publication date | 1997-06-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice | |
| P478 | volume | 94 |
| Q34990282 | A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs |
| Q45140144 | A new type of protein methylation activated by tyrphostin A25 and vanadate |
| Q45044385 | A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus |
| Q43840915 | Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice |
| Q35044254 | Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging |
| Q46984100 | Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome |
| Q45230287 | Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice |
| Q45887917 | Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice |
| Q34348827 | Age-dependent deamidation of asparagine residues in proteins |
| Q35119508 | Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair |
| Q53798547 | Altered immunogenicity of isoaspartate containing proteins. |
| Q28509395 | Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice |
| Q41959077 | Amyloid β Modification: A Key to the Sporadic Alzheimer's Disease? |
| Q38289390 | Amylose recognition and ring-size determination of amylomaltase |
| Q41970463 | Analysis of isoaspartic Acid by selective proteolysis with Asp-N and electron transfer dissociation mass spectrometry |
| Q46051642 | Analysis of oxidative modification of proteins |
| Q42169543 | Analysis of oxidative modification of proteins. |
| Q33905239 | Are ancient proteins responsible for the age-related decline in health and fitness? |
| Q28588204 | Biochemical studies of Zmpste24-deficient mice |
| Q33185973 | Biotin limitation in Sinorhizobium meliloti strain 1021 alters transcription and translation. |
| Q37282869 | Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice |
| Q35200145 | Brain tumor and seizures: pathophysiology and its implications for treatment revisited |
| Q44144612 | Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11. |
| Q28270469 | Complex interactions of the protein L-isoaspartyl methyltransferase and calmodulin revealed with the yeast two-hybrid system |
| Q34384948 | Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein |
| Q24645256 | Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site |
| Q46537507 | Crystal structure of isoaspartyl aminopeptidase in complex with L-aspartate |
| Q27628392 | Crystal structure of protein isoaspartyl methyltransferase: a catalyst for protein repair |
| Q78017645 | D-amino acids in aging erythrocytes |
| Q33267003 | DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. |
| Q36476874 | Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation |
| Q36596625 | Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues |
| Q46843070 | Differentiation of aspartic and isoaspartic acids using electron transfer dissociation |
| Q28346716 | Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants |
| Q47147272 | Distinguishing Aspartic and Isoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentation Methods |
| Q37802272 | Enzymatic repair of Amadori products |
| Q41720371 | Epilepsy genetics: an abundance of riches for biologists. |
| Q37838314 | Epilepsy in the cancer patient |
| Q77488392 | Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes |
| Q33952649 | Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase |
| Q37618834 | FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. |
| Q90711238 | Functional divergence of annotated l-isoaspartate O-methyltransferases in an α-proteobacterium |
| Q44401707 | Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis |
| Q35757100 | Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes |
| Q34315577 | Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin |
| Q58765987 | Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation |
| Q46175954 | Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice |
| Q38663198 | Increased protein glycation in fructosamine 3-kinase-deficient mice |
| Q28141693 | Inhibition of GTPgammaS-dependent L-isoaspartyl protein methylation by tyrosine kinase inhibitors in kidney |
| Q28076999 | Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling |
| Q30426046 | Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice |
| Q35041665 | Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent |
| Q44276432 | Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain |
| Q33892718 | Isoaspartate in peptides and proteins: formation, significance, and analysis |
| Q39495570 | Isoaspartate in ribosomal protein S11 of Escherichia coli |
| Q35163505 | Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury |
| Q33793594 | Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse |
| Q40236620 | Isoaspartyl post-translational modification triggers anti-tumor T and B lymphocyte immunity. |
| Q37637164 | Isoaspartyl protein damage and repair in mouse retina |
| Q39304645 | Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. |
| Q43560357 | Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice. |
| Q34397059 | Lupus autoantigens: their origins, forms, and presentation |
| Q33844451 | MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. |
| Q35524497 | Mice that express farnesylated versions of prelamin A in neurons develop achalasia |
| Q36963289 | Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets |
| Q39210550 | Mitochondrial uncoupler carbonyl cyanide M-chlorophenylhydrazone induces the multimer assembly and activity of repair enzyme protein L-isoaspartyl methyltransferase |
| Q34695506 | Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms. |
| Q37086218 | N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro |
| Q55260219 | New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation. |
| Q34517589 | Non-enzymatic covalent modifications of proteins: mechanisms, physiological consequences and clinical applications |
| Q33761245 | Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae |
| Q35676307 | Novel aspects of macromolecular repair and relationship to human disease |
| Q44607670 | Overexpression of l-Isoaspartate O-Methyltransferase in Escherichia coli Increases Heat Shock Survival by a Mechanism Independent of Methyltransferase Activity |
| Q37300033 | PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case-control study in a population with relatively low folate intake |
| Q50485604 | PROTEIN L-ISOASPARTYL METHYLTRANSFERASE2 is differentially expressed in chickpea and enhances seed vigor and longevity by reducing abnormal isoaspartyl accumulation predominantly in seed nuclear proteins. |
| Q41678289 | Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase. |
| Q46333509 | Polymorphic Variants of Human Protein l-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability: IMPLICATIONS FOR THE ETIOLOGY OF NEUROLOGICAL DISORDERS AND COGNITIVE AGING. |
| Q38851366 | Post-translational protein arginylation in the normal nervous system and in neurodegeneration |
| Q92654790 | Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage? |
| Q46312578 | Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B. |
| Q42640037 | Protein L-isoaspartyl methyltransferase1 (CaPIMT1) from chickpea mitigates oxidative stress-induced growth inhibition of Escherichia coli |
| Q73224093 | Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis |
| Q43977198 | Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes: role of oxidative stress |
| Q40465066 | Protein repair L-isoaspartyl methyltransferase 1 (PIMT1) in rice improves seed longevity by preserving embryo vigor and viability. |
| Q82617246 | Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis |
| Q46118403 | Protein repair L-isoaspartyl methyltransferase in plants. Phylogenetic distribution and the accumulation of substrate proteins in aged barley seeds |
| Q46753891 | Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain |
| Q37072617 | Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans |
| Q82423680 | Proteomic Response to Sublethal Cadmium Exposure in a Sentinel Fish Species, Cottus gobio |
| Q33254719 | Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme |
| Q44251504 | Quantification of the isomerization of Asp residue in recombinant human alpha A-crystallin by reversed-phase HPLC. |
| Q28278865 | Regulation of protein L-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome |
| Q41048721 | Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain |
| Q28473640 | Retracted: Protein Isoaspartate Methyltransferase Prevents Apoptosis Induced by Oxidative Stress in Endothelial Cells: Role of Bcl-Xl Deamidation and Methylation |
| Q39912305 | Rice PROTEIN l-ISOASPARTYL METHYLTRANSFERASE isoforms differentially accumulate during seed maturation to restrict deleterious isoAsp and reactive oxygen species accumulation and are implicated in seed vigor and longevity. |
| Q36939985 | Role of transmethylation reactions in alcoholic liver disease |
| Q93089168 | Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease |
| Q27651575 | Structural Investigation of a Phosphorylation-Catalyzed, Isoaspartate-Free, Protein Succinimide: Crystallographic Structure of Post-Succinimide His15Asp Histidine-Containing Protein † ‡ |
| Q91768292 | Structural and biochemical basis of the formation of isoaspartate in the complementarity-determining region of antibody 64M-5 Fab |
| Q43691982 | Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme. |
| Q80385150 | Structure and function of a mitochondrial late embryogenesis abundant protein are revealed by desiccation |
| Q46465134 | Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain |
| Q28586789 | Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells |
| Q36168355 | Techniques for studying protein heterogeneity and post-translational modifications |
| Q36979979 | The 2010 ESPEN Sir David Cuthbertson Lecture: new and old proteins: clinical implications |
| Q36540546 | The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression? |
| Q33730748 | The L-isoaspartyl protein repair methyltransferase enhances survival of aging Escherichia coli subjected to secondary environmental stresses |
| Q37420318 | The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface |
| Q42567321 | The amino terminus of PKA catalytic subunit--a site for introduction of posttranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymes |
| Q22003759 | The carboxyl methyltransferase modifying G proteins is a metalloenzyme |
| Q30330457 | The influence of protein structure on the products emerging from succinimide hydrolysis. |
| Q27335277 | The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans |
| Q39937281 | The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation |
| Q43821424 | Theoretical study on isomerization and peptide bond cleavage at aspartic residue. |
| Q37373293 | Toward proteome-scale identification and quantification of isoaspartyl residues in biological samples. |
| Q44069116 | Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency |
| Q73798431 | Translation of a unique transcript for protein isoaspartyl methyltransferase in haploid spermatids: implications for protein storage and repair |
| Q27315945 | Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice |
Search more.