Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease

scientific article published on 07 August 2019

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACSCENTSCI.9B00369
P932PMC publication ID6716341
P698PubMed publication ID31482121

P50authorRyan R JulianQ57069223
P2093author name stringJin Tang
Byron D Ford
Amrik S Kang
Dylan L Riggs
Lance E Talbert
Catherine Augello
Emily Coburn
Jessica Noll
Tyler R Lambeth
P2860cites workStructural basis for the recognition and cleavage of histone H3 by cathepsin LQ24293301
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunctionQ24603159
Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsyQ28263286
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMRQ28387681
Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kineticsQ28681651
Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lensesQ28743054
Autophagy: process and functionQ29547296
Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseQ29616534
3D structure of Alzheimer's amyloid-beta(1-42) fibrilsQ29617475
Tau-mediated neurodegeneration in Alzheimer's disease and related disordersQ29618148
Molecular clocksQ30327762
Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?Q30333347
Identification of Sequence Similarities among Isomerization Hotspots in Crystallin ProteinsQ30399065
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradationQ30406473
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro agingQ33227600
Identification and quantification of degradations in the Asp-Asp motifs of a recombinant monoclonal antibodyQ33315204
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neuronsQ57203231
Structural and functional consequences of age-related isomerization in α-crystallinsQ64105433
The effects of aspartic acid-bond isomerization on in vitro properties of the amyloid beta-peptide as modeled with N-terminal decapeptide fragmentsQ71342152
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptideQ33515877
Pathway for polyarginine entry into mammalian cellsQ33644922
Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoidQ33956569
Neuronal loss and brain atrophy in mice lacking cathepsins B and LQ34030250
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.Q34061717
Autophagy failure in Alzheimer's disease--locating the primary defectQ34987827
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategiesQ35152946
Intrinsically unstructured proteins evolve by repeat expansionQ35206014
Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic MiceQ35913908
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.Q36179871
Biological significance of isoaspartate and its repair systemQ36248677
Proteases and proteolysis in the lysosomeQ36777562
Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosomeQ36795149
Identification of long-lived proteins reveals exceptional stability of essential cellular structuresQ37210826
Lysosomal solute carrier transporters gain momentum in researchQ37323256
Autophagy, mitochondria and cell death in lysosomal storage diseases.Q37421398
Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.Q37485553
Site-specific characterization of (D)-amino acid containing peptide epimers by ion mobility spectrometryQ37724249
Specific functions of lysosomal proteases in endocytic and autophagic pathways.Q37902291
The biogenesis of lysosomes and lysosome-related organellesQ38245721
Isomerization of aspartyl residues in crystallins and its influence upon cataractQ38566934
Proteostasis and agingQ38662553
Old Proteins in Man: A Field in its InfancyQ38900143
Proteasomal and Autophagic Degradation SystemsQ39275553
Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial diseaseQ39405747
Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma2 antibody highlights the role avidity plays in antibody activityQ40018957
D-amino acids in animal peptidesQ41550207
Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilizationQ44083672
Quantification of the isomerization of Asp residue in recombinant human alpha A-crystallin by reversed-phase HPLC.Q44251504
Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brainQ46753891
Strategies for analysis of isomeric peptides.Q47784780
Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domainQ47833824
Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.Q48270156
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brainQ48443930
Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.Q48920516
Peripherally applied synthetic peptide isoAsp7-Aβ(1-42) triggers cerebral β-amyloidosis.Q50996852
Differences in α-Crystallin isomerization reveal the activity of protein isoaspartyl methyltransferase (PIMT) in the nucleus and cortex of human lenses.Q51760097
Molecular and Physiological Characterization of a Receptor for d-Amino Acid-Containing Neuropeptides.Q52654209
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.Q53233672
P433issue8
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1387-1395
P577publication date2019-08-07
P1433published inACS Central ScienceQ27726586
P1476titleSpontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease
P478volume5

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Q96438342Recent Progress in the Analysis of Protein Deamidation Using Mass Spectrometrycites workP2860

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