Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

scientific article published on 4 April 2012

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11357-012-9403-0
P932PMC publication ID3636379
P698PubMed publication ID22477259
P5875ResearchGate publication ID223959096

P50authorLine De KimpeQ39200751
P2093author name stringHelma Rutjes
Wiep Scheper
Elise S van Haastert
Jeroen J M Hoozemans
Rob Zwart
Archontia Kaminari
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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisQ29547501
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditionsQ30320504
Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelQ30489966
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosisQ30497751
Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's diseaseQ31853538
Binding and uptake of A beta1-42 by primary human astrocytes in vitroQ33390631
Accumulation of intraneuronal Abeta correlates with ApoE4 genotypeQ33771171
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficitsQ34438646
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashionQ36370419
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Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.Q40057785
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.Q40677042
Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's diseaseQ41870879
Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteinsQ43026196
Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systemsQ43996363
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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathologyQ46330873
Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with agingQ47600265
Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's diseaseQ47962016
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic miceQ48846848
Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brainQ48917681
Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's diseaseQ49097822
Phagocytic activity of human adult astrocytes and oligodendrocytes in cultureQ69531270
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brainQ74290658
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)Q79212522
N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosisQ80217620
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue3
P304page(s)673-687
P577publication date2012-04-04
P1433published inAgeQ4691832
P1476titleIntracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
P478volume35

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