Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice

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Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.115.225490
P932PMC publication ID4613962
P698PubMed publication ID26354996

P2093author name stringWei Zhang
Chi Wang
Andrew J Morris
Manjula Sunkara
Jun Deng
Mary Vore
Daret St Clair
Luksana Chaiswing
Paiboon Jungsuwadee
Donna Coy
P2860cites workOverexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligaseQ24646459
Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleQ27026649
Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative StressQ30475538
Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacingQ30513562
The role of glutathione in brain tumor drug resistanceQ34029649
Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosisQ34098345
Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport functionQ34416223
Ventricular pacing-induced loss of contractile function and development of epicardial inflammationQ34784701
In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1.Q34914312
Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathwaysQ35189521
Isoprostane generation and functionQ35332267
The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenalQ35840905
Loss of multidrug resistance-associated protein 1 potentiates chronic doxorubicin-induced cardiac dysfunction in miceQ36186168
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiationQ36620467
Short- and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury.Q36844644
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic miceQ37359529
Doxorubicin cardiotoxicity: analysis of prevailing hypothesesQ37958656
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategiesQ37998724
Chemotherapeutic drugs inhibit ribosome biogenesis at various levelsQ39738796
Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathyQ39891233
Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 miceQ40205232
Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclinesQ40816971
Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenalQ40860668
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.Q41077699
Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehydeQ41735252
Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.Q42478190
Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injuryQ45191347
Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heartQ45410654
NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicityQ46837798
Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1.Q54092581
Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heartQ69609656
Genotoxic properties of 4-hydroxyalkenals and analogous aldehydesQ72104243
Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucolQ73108705
Doxorubicin-induced acute changes in cytotoxic aldehydes, antioxidant status and cardiac function in the ratQ73133157
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)272-279
P577publication date2015-09-09
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleElevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice
P478volume355

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cites work (P2860)
Q37023604Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts
Q36186168Loss of multidrug resistance-associated protein 1 potentiates chronic doxorubicin-induced cardiac dysfunction in mice
Q36245459Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study.
Q52587039THE ROLE OF PROTEIN CHAPERONES IN THE SURVIVAL FROM ANTHRACYCLINE-INDUCED OXIDATIVE STRESS IN SACCHAROMYCES CEREVISIAE.