Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function

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Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1068965665
P356DOI10.2119/MOLMED.2014.00059
P932PMC publication ID4212010
P698PubMed publication ID25105301

P2093author name stringFang Wang
Li-wu Fu
Xiao-kun Wang
Zhen-cong Huang
Yi-fan Chen
Shao-lin Ma
Ya-peng Hu
P2860cites workOverexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
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Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cellsQ73941067
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Plant ATP-binding cassette transportersQ34607674
Mammalian ABC transporters in health and diseaseQ34667449
Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinibQ35002433
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Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
A single-arm phase II trial of first-line paclitaxel in combination with lapatinib in HER2-overexpressing metastatic breast cancerQ37810735
Assessment of cytochrome p450 enzyme inhibition and inactivation in drug discovery and developmentQ37841644
ABC transporters and their role in nucleoside and nucleotide drug resistanceQ37979617
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistanceQ38510908
Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells.Q38618124
Nilotinib enhances the efficacy of conventional chemotherapeutic drugs in CD34⁺CD38⁻ stem cells and ABC transporter overexpressing leukemia cellsQ39013427
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistanceQ39805970
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxolQ40036920
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cellsQ40144190
Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivoQ40345597
Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.Q40410062
Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.Q40530013
Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded materialQ40633176
Resistant mechanisms of anthracyclines--pirarubicin might partly break through the P-glycoprotein-mediated drug-resistance of human breast cancer tissuesQ40757148
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cellsQ41073847
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cellsQ42833544
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Q44450066
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistanceQ44687014
Expression of lung resistance-related protein (LRP) in initial and relapsed childhood acute lymphoblastic leukemiaQ44799762
Screening novel, potent multidrug-resistant modulators from imidazole derivativesQ45011364
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cellsQ47968983
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)390-399
P577publication date2014-09-08
P1433published inMolecular MedicineQ6895961
P1476titleLapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function
P478volume20

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cites work (P2860)
Q37739472Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo
Q33596508Detection approaches for multidrug resistance genes of leukemia
Q36186203Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice
Q52651567Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway.
Q36232153Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes
Q38743568Novel ABCG2 Antagonists Reverse Topotecan-Mediated Chemotherapeutic Resistance in Ovarian Carcinoma Xenografts
Q57816977Olmutinib (BI1482694/HM61713), a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses ABCG2-Mediated Multidrug Resistance in Cancer Cells
Q49888021Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells.

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