How do you design randomised trials for smaller populations? A framework.

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How do you design randomised trials for smaller populations? A framework. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S12916-016-0722-3
P932PMC publication ID5123370
P698PubMed publication ID27884190

P50authorTim MorrisQ42652887
Matthew R SydesQ44571830
P2093author name stringMahesh K B Parmar
P2860cites workWhy most published research findings are falseQ21092395
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and designQ24569560
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good RQ30357731
The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studiesQ33617148
Assessing potential sources of clustering in individually randomised trialsQ34670307
Variance reduction in randomised trials by inverse probability weighting using the propensity scoreQ34844677
Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchersQ34996360
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatmentQ35005741
A re-randomisation design for clinical trialsQ35834036
Clinical trial designs for rare diseases: studies developed and discussed by the International Rare Cancers InitiativeQ36265620
Leveraging prognostic baseline variables to gain precision in randomized trialsQ37246685
Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) reviewQ38210083
Methodology of clinical trials for rare diseasesQ38224081
Innovative research methods for studying treatments for rare diseases: methodological reviewQ38271185
Research methods to change clinical practice for patients with rare cancers.Q38730151
New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation studyQ38888445
Bayesian methods for the design and interpretation of clinical trials in very rare diseasesQ41908823
Medical research: Trial unpredictability yields predictable therapy gainsQ42920052
Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trialQ46221067
Novel designs for multi-arm clinical trials with survival outcomes with an application in ovarian cancerQ47768935
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)183
P577publication date2016-11-25
P1433published inBMC MedicineQ4835947
P1476titleHow do you design randomised trials for smaller populations? A framework
P478volume14

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cites work (P2860)
Q42363435A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
Q58695016A small population, randomised, placebo-controlled trial to determine the efficacy of anakinra in the treatment of pustular psoriasis: study protocol for the APRICOT trial
Q47160419A systematic literature review of evidence-based clinical practice for rare diseases: what are the perceived and real barriers for improving the evidence and how can they be overcome?
Q91949479An evaluation of inverse probability weighting using the propensity score for baseline covariate adjustment in smaller population randomised controlled trials with a continuous outcome
Q59136188Applicability and added value of novel methods to improve drug development in rare diseases
Q45943629Fact or fiction: reducing the proportion and impact of false positives.
Q64039462Incorporating individual historical controls and aggregate treatment effect estimates into a Bayesian survival trial: a simulation study
Q38735691Physical Activity Self-Management and Coaching Compared to Social Interaction in Huntington Disease: Results From the ENGAGE-HD Randomized, Controlled, Pilot Feasibility Trial
Q47158264Physical Therapy and Exercise Interventions in Huntington's Disease: A Mixed Methods Systematic Review

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