Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow

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Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1167576M
P356DOI10.1371/JOURNAL.PONE.0167576
P932PMC publication ID5132265
P698PubMed publication ID27907146

P50authorRichard L LeaskQ61826564
P2093author name stringScott Cooper
Karli K McDonald
Lisa Danielzak
P2860cites workLeukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flowQ27027232
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Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophilsQ30427418
The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.Q30472504
Endothelial dysfunction, hemodynamic forces, and atherosclerosisQ33800323
Neutrophil adhesion on endothelial cells in a novel asymmetric stenosis model: effect of wall shear stress gradientsQ34043689
Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosisQ34171790
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cellsQ34229735
The structural stability of the endothelial glycocalyx after enzymatic removal of glycosaminoglycansQ34384811
Endothelial surface glycocalyx can regulate flow-induced nitric oxide production in microvessels in vivoQ34894458
Imaging the endothelial glycocalyx in vitro by rapid freezing/freeze substitution transmission electron microscopyQ35120425
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokinesQ35749970
Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress.Q51015457
Shear Stress Increases ICAM-1 and Decreases VCAM-1 and E-selectin Expressions Induced by Tumor Necrosis Factor-α in Endothelial CellsQ51798496
Shear Stress-Induced Cytoskeleton Rearrangement Mediates NF-κB-Dependent Endothelial Expression of ICAM-1Q57703713
Fluid shear stress modulates surface expression of adhesion molecules by endothelial cellsQ57704301
Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteriesQ68737335
Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitroQ70721125
Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stressQ71693098
Effects of Shear Stress on Glycosaminoglycan Synthesis in Vascular Endothelial CellsaQ72107239
Flow stimulates ICAM-1 expression time and shear stress dependently in cultured human endothelial cellsQ72442020
Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surfaceQ73652344
Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective forceQ74582573
Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolaeQ77359709
Concentration and time effects of dextran exposure on endothelial cell viability, attachment, and inflammatory marker expression in vitroQ82673853
The response of human aortic endothelial cells in a stenotic hemodynamic environment: effect of duration, magnitude, and spatial gradients in wall shear stressQ84506664
Endothelial cell morphologic response to asymmetric stenosis hemodynamics: effects of spatial wall shear stress gradientsQ84615330
An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shearQ36288156
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigrationQ36399827
Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stressQ36495182
Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cellsQ36538831
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation.Q36947609
Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.Q37142789
The tail of integrins, talin, and kindlinsQ37483142
Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 sheddingQ37575892
The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" modelQ37693164
A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcriptionQ38322185
Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cellsQ38350447
Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransductionQ38516333
Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells.Q39652316
Inhibition of NF-kappaB DNA binding by nitric oxideQ39716552
Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.Q39853520
All-trans-retinoic acid counteracts endothelial cell procoagulant activity induced by a human promyelocytic leukemia-derived cell line (NB4).Q41239267
The development of 3-D, in vitro, endothelial culture models for the study of coronary artery diseaseQ41789980
The role of endothelial glycocalyx components in mechanotransduction of fluid shear stressQ42508107
The recovery time course of the endothelial cell glycocalyx in vivo and its implications in vitroQ42586862
Differential Response of Endothelial Cells to Simvastatin When Conditioned with Steady, Non-Reversing Pulsatile or Oscillating Shear StressQ42926780
Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress.Q43056627
Role of glycocalyx in leukocyte-endothelial cell adhesionQ44138368
Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial CellsQ44620897
Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding.Q44626801
Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcationQ46697077
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
glycocalyxQ898356
P304page(s)e0167576
P577publication date2016-12-01
P1433published inPLOS OneQ564954
P1476titleGlycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow
P478volume11

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Q93111034Endothelial barrier reinforcement relies on flow-regulated glycocalyx, a potential therapeutic target
Q92925933Endothelial glycocalyx as a potential theriapeutic target in organ injuries
Q90293203Flow-regulated endothelial glycocalyx determines metastatic cancer cell activity
Q58715416Increased MMP activity in curved geometries disrupts the endothelial cell glycocalyx creating a proinflammatory environment
Q88574772Large-Volume Crystalloid Fluid Is Associated with Increased Hyaluronan Shedding and Inflammation in a Canine Hemorrhagic Shock Model
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Q58742915Skin Sodium and Hypertension: a Paradigm Shift?
Q50888294Stenosis Hemodynamics Disrupt the Endothelial Cell Glycocalyx by MMP Activity Creating a Proinflammatory Environment.

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