Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling

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Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1168696X
P356DOI10.1371/JOURNAL.PONE.0168696
P932PMC publication ID5167405
P698PubMed publication ID27992555

P2093author name stringFei Xing
Hidemi Yoshida
Tadaatsu Imaizumi
Tomoh Matsumiya
Ryo Hayakari
Yuko Shiba
P2860cites workIkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domainQ22010650
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1Q24293229
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transductionQ24319109
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Q24319941
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear importQ44885075
Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CC chemokine ligand (CCL) 5 in human mesangial cellsQ45122083
Retinoic acid-inducible gene-I is induced in gingival fibroblasts by lipopolysaccharide or poly IC: possible roles in interleukin-1beta, -6 and -8 expression.Q54574575
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKKQ58443825
A diverse range of gene products are effectors of the type I interferon antiviral responseQ24626018
Function and regulation of retinoic acid-inducible gene-IQ24632537
Beyond NF-κB activation: nuclear functions of IκB kinase αQ27026953
Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factorsQ27318543
Interferon-inducible antiviral effectorsQ27486790
Pathogen recognition and innate immunityQ27861084
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylationQ28140878
AP-1 subunits: quarrel and harmony among siblingsQ28295184
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9Q28507728
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
The IKK complex: an integrator of all signals that activate NF-kappaB?Q33877083
The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formationQ34301763
Type I interferon receptors: biochemistry and biological functions.Q34628239
Of JAKs, STATs, blind watchmakers, jeeps and trainsQ35163904
Interferon-stimulated genes and their antiviral effector functionsQ35742006
IKK biologyQ35848596
IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivationQ35888836
Stats: multifaceted regulators of transcriptionQ36351955
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosisQ36368249
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infectionQ36706104
Type I interferons in viral control and immune regulationQ36767643
Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assemblyQ36913366
Recognition of viral nucleic acids in innate immunityQ37664675
Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathwayQ37683123
Molecular regulation of interferon antiviral response in fishQ38020636
STAT2 and IRF9: Beyond ISGF3.Q38185399
The role of the IKK complex in viral infectionsQ38235888
Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I interferon (IFN)-dependent and type I IFN-independent pathwaysQ39279869
Fish virus-induced interferon exerts antiviral function through Stat1 pathwayQ39680764
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathwaysQ40139227
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient miceQ40442637
Nuclear signaling by interleukin-6.Q40886092
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)e0168696
P577publication date2016-12-19
P1433published inPLOS OneQ564954
P1476titleNon-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling
P478volume11

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