I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

scientific article published on 19 February 2013

I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2013.28
P932PMC publication ID3604721
P698PubMed publication ID23422957
P5875ResearchGate publication ID235669407

P50authorMichael KarinQ1458081
Hongbo ChiQ56509438
Alessandra MancinoQ63627545
Michael SeedQ44687271
Jorge H CaamanoQ55300569
Toby LawrenceQ56433255
P2093author name stringXuefeng Wu
Mohamed Habbeddine
Carol Fong
Marc Bajenoff
Magali Bebien
Ella Johnson
Lionel Luron
Sylvie Memet
P2860cites workTAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-betaQ24311833
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1Q24315115
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimersQ24562579
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Pattern recognition receptors and inflammationQ27861115
Triggering the interferon antiviral response through an IKK-related pathwayQ28191761
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activationQ28252726
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptorsQ28260114
Regulation and function of IKK and IKK-related kinasesQ28268930
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9Q28507728
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domainsQ28608956
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper functionQ56880717
Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7Q57174613
Animal models of rheumatoid arthritisQ57232000
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammationQ59054264
The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondiiQ73050577
Toll-like receptors control activation of adaptive immune responsesQ74486847
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cellsQ77769122
IRF-3 releases its inhibitionsQ81194396
Dendritic cells in vivo: a key target for a new vaccine scienceQ81980748
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigensQ29615098
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
Characterization of the interferon-producing cell in mice infected with Listeria monocytogenesQ33422966
Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria in the mouseQ33634008
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).Q33934033
Modulation of adaptive immunity with Toll-like receptorsQ34016666
Macrophages as APC and the dendritic cell mythQ34599073
Regulation of adaptive immunity by the innate immune systemQ34659642
NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responsesQ35208356
Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.Q35750832
Immune responses to Listeria monocytogenesQ35906097
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectionQ35978569
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.Q36229473
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosisQ36368249
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.Q36403615
Human listeriosis and animal modelsQ36919580
NF-κB and Innate ImmunityQ37789670
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.Q38342766
A new symmetrodont mammal from China and its implications for mammalian evolutionQ38555150
Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.Q38734490
Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.Q39362980
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.Q40125826
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathwaysQ40139227
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activationQ40602643
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinaseQ40665780
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodelingQ42252373
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell HelpQ42642562
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signalQ42834238
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingQ43142702
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.Q52542561
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.Q53530644
Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.Q54689085
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)816-828
P577publication date2013-02-19
P1433published inThe EMBO JournalQ1278554
P1476titleI kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection
P478volume32

Reverse relations

cites work (P2860)
Q37548680Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice
Q34323795Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming
Q42085969IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.
Q40101022In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.
Q36228458Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling
Q91179645Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages
Q35001723The IκB kinase complex in NF-κB regulation and beyond
Q40166981Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons

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