Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity

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Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.20061839
P932PMC publication ID2118721
P698PubMed publication ID17261635
P5875ResearchGate publication ID6541951

P50authorSergio E BaranziniQ56761680
Jorge R. OksenbergQ110220860
P2093author name stringShalina S Ousman
Lawrence Steinman
Raymond A Sobel
Sawsan Youssef
Andrea Crowell
John Loh
Luis Zuniga
Shannon E Dunn
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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
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It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.Q34754748
Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.Q34762330
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responsesQ34830426
Emerging roles of PPARs in inflammation and immunityQ34931884
Androgen treatment prevents diabetes in nonobese diabetic miceQ36231269
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Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.Q40756152
Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-gamma productionQ40786707
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Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells.Q40981150
Genetic control of the CD4/CD8 T-cell ratio in humans.Q41653812
Gender-dependent IL-12 secretion by APC is regulated by IL-10.Q41740131
Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cellsQ42048911
Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenolQ42108242
Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 productionQ43699058
Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormonesQ44253408
Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activationQ44484556
Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosisQ44514299
Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.Q44708828
Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).Q44881100
Gender bias in Theiler's virus-induced demyelinating disease correlates with the level of antiviral immune responsesQ45424018
The distribution of serum immunoglobulins, anti-gamma-G globulins ("rheumatoid factors") and antinuclear antibodies in White and Negro subjects in Evans County, GeorgiaQ46475971
Age and sex associations of 40 autoimmune diseasesQ47306926
L-FABP is exclusively expressed in alveolar macrophages within the myeloid lineage: evidence for a PPARalpha-independent expressionQ47328826
The neuroendocrine axis in patients with multiple sclerosisQ48691841
Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response.Q50949591
Sex differences in susceptibility to viral infection of the central nervous system.Q51022946
Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis.Q51835987
A gender gap in autoimmunity.Q55032884
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1Q57244351
Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific mannerQ57502657
Androgen replacement therapy in male patients with rheumatoid arthritisQ67897215
Sex differences in cytokine responses to myelin peptides in multiple sclerosisQ74775389
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)321-330
P577publication date2007-01-29
P1433published inJournal of Experimental MedicineQ3186912
P1476titlePeroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity
P478volume204

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