Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

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Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1998PNAS...95.8985H
P356DOI10.1073/PNAS.95.15.8985
P932PMC publication ID21189
P698PubMed publication ID9671791
P5875ResearchGate publication ID13612768

P2093author name stringUllrich A
Schultz G
Gudermann T
Herrlich P
Daub H
Herrlich A
Knebel A
P2860cites workProtein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functionsQ24307776
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activationQ24312845
Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activationQ24318340
UV activation of receptor tyrosine kinase activity.Q42825324
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.Q46028427
Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptorQ46311910
Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle CellsQ57908184
The mammalian ultraviolet response is triggered by activation of src tyrosine kinasesQ60621256
rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasionQ70993690
Participation of reactive oxygen species in the lysophosphatidic acid-stimulated mitogen-activated protein kinase kinase activation pathwayQ71585821
Calcium influx induces neurite growth through a Src-Ras signaling cassetteQ71623696
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activationQ71891876
Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cellsQ72259808
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathwayQ72695157
Involvement of growth factor receptors in the mammalian UVC responseQ72710815
Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytesQ72724106
Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cellsQ72724940
Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaQ24328857
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoQ24336223
The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytesQ24562884
Signaling by the G12 class of G proteinsQ28292342
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRFQ28292490
A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious pubertyQ28298512
Two G protein oncogenes in human endocrine tumorsQ28301270
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CQ28327651
Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channelsQ28577212
G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptorQ28582689
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
Regulation of transcription by MAP kinase cascadesQ29618477
Gi-mediated activation of the Ras/MAP kinase pathway involves a 100kDa tyrosine-phosphorylated Grb2 SH3 binding protein,but not Src nor ShcQ30176516
Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signalingQ30176895
The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factorQ30176898
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathwayQ30193170
Involvement of pp60c-src with two major signaling pathways in human breast cancerQ30194582
Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogeneQ30441810
Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C.Q34384615
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptorQ35845039
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21rasQ35999209
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblastsQ36097786
The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cellsQ36485178
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cellsQ37627890
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomasQ38315242
Lysophosphatidic acid signallingQ40444988
G Protein-Coupled Receptor Systems Involved in Cell Growth and OncogenesisQ40480662
Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator.Q40567927
Tyrosine kinase inhibition: an approach to drug developmentQ40613606
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerizationQ40677644
Diversity and selectivity of receptor-G protein interactionQ41048215
Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesisQ41077471
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agentsQ41077480
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.Q41183644
Protein tyrosine kinase receptorsQ41203769
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsQ41229236
Mitogenic signaling via G protein-coupled receptorsQ41273289
Novel mechanisms of RTK signal generationQ41345484
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.Q41461969
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cellsQ41480315
Association between the PDGF receptor and members of the src family of tyrosine kinasesQ41725198
Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cellsQ41728307
Signal characteristics of G protein-transactivated EGF receptorQ41960343
Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.Q42160798
Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformationQ42282342
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)8985-8990
P577publication date1998-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLigand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells
P478volume95