| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1045781397 |
| P356 | DOI | 10.1038/376781A0 |
| P953 | full work available at URL | http://www.nature.com/articles/376781a0 |
| http://www.nature.com/articles/376781a0.pdf | ||
| P698 | PubMed publication ID | 7651538 |
| P50 | author | Robert Lefkowitz | Q80910 |
| P2093 | author name string | R. J. Lefkowitz | |
| T. van Biesen | |||
| D. K. Luttrell | |||
| M. Sakaue | |||
| K. Touhara | |||
| L. M. Luttrell | |||
| B. E. Hawes | |||
| E. Porfiri | |||
| K. M. Krueger | |||
| P2860 | cites work | A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways | Q40021572 |
| Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. | Q41461969 | ||
| Malignant transformation of early passage rodent cells by a single mutated human oncogene | Q59075298 | ||
| Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation | Q71891876 | ||
| G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor | Q71921039 | ||
| Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions | Q24307776 | ||
| Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase | Q24562166 | ||
| Protein modules and signalling networks | Q27860694 | ||
| PH domain: the first anniversary | Q28242218 | ||
| Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | Q28268458 | ||
| Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor | Q29616395 | ||
| Involvement of pp60c-src with two major signaling pathways in human breast cancer | Q30194582 | ||
| Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors | Q34237289 | ||
| Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras | Q35999209 | ||
| Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts | Q36097786 | ||
| Signal transduction via the MAP kinases: proceed at your own RSK. | Q36381460 | ||
| Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. | Q39481540 | ||
| P433 | issue | 6543 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | signal transduction | Q828130 |
| signal transducing adaptor protein | Q5964993 | ||
| vesicular transport adaptor proteins | Q30587697 | ||
| P304 | page(s) | 781-784 | |
| P577 | publication date | 1995-08-01 | |
| 1995-08-31 | |||
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway | |
| Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway | |||
| P478 | volume | 376 |
| Q42550851 | 5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3. |
| Q40879246 | A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts. |
| Q42817181 | A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. |
| Q24647689 | A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion |
| Q37325629 | A novel noncanonical signaling pathway for the μ-opioid receptor |
| Q33925096 | A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase |
| Q28609040 | A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3 |
| Q30669159 | A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics |
| Q24312845 | A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation |
| Q40820783 | ADP-induced platelet aggregation and inhibition of adenylyl cyclase activity stimulated by prostaglandins: signal transduction mechanisms |
| Q40018902 | AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction |
| Q34677473 | Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors. |
| Q33856613 | Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor |
| Q73469669 | Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats |
| Q48203981 | Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes. |
| Q74510339 | Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive |
| Q54104814 | Activation of stress-activated protein kinase/c-Jun NH2-terminal kinase and p38 kinase in calphostin C-induced apoptosis requires caspase-3-like proteases but is dispensable for cell death. |
| Q22010516 | Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) |
| Q44367008 | Activation of the MAP kinase cascade by exogenous calcium-sensing receptor |
| Q42812543 | Activation of the Ras-GRF/CDC25Mm exchange factor by lysophosphatidic acid |
| Q73320061 | Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain |
| Q62011110 | Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus |
| Q41111135 | Adaptors and integrators |
| Q41150843 | Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation |
| Q41039407 | Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor- |
| Q40963866 | Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells |
| Q40916749 | Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase |
| Q44347369 | Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor |
| Q42661182 | All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. |
| Q22254614 | Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells |
| Q33709291 | Alpha1-adrenoceptor subtypes |
| Q78206084 | Alpha2-adrenergic effect on human breast cancer MCF-7 cells |
| Q40592082 | An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension |
| Q43096044 | Angiotensin II responses of vascular smooth muscle cells from hypertensive rats: enhancement at the level of p42 and p44 mitogen activated protein kinase. |
| Q33183333 | Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density |
| Q24305547 | Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit |
| Q40885973 | Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes |
| Q44042949 | Big G, little G: G proteins and actin cytoskeletal reorganization |
| Q24673628 | Biological significance of agmatine, an endogenous ligand at imidazoline binding sites |
| Q42631549 | Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase |
| Q41158190 | Bradykinin B2 receptor-induced and inositol tetrakisphosphate-evoked Ca2+ entry is sensitive to a protein tyrosine phosphorylation inhibitor in ras-transformed NIH/3T3 fibroblasts. |
| Q41874156 | Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle |
| Q42809319 | CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways |
| Q73066795 | Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse B2 bradykinin receptor: tyrosine kinase inhibitor-sensitive and- insensitive processes |
| Q43906796 | CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle |
| Q38835689 | Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility |
| Q33874444 | Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase |
| Q34040153 | Cellular actions of nociceptin: transduction mechanisms. |
| Q40912842 | Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm). |
| Q43171053 | Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism |
| Q52551615 | Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein. |
| Q34007473 | Chemokine and cytokine cooperativity: eosinophil migration in the asthmatic response |
| Q37222198 | Chemokine signaling in cancer: one hump or two? |
| Q42807922 | Cholecystokinin stimulates formation of shc-grb2 complex in rat pancreatic acinar cells through a protein kinase C-dependent mechanism. |
| Q41461077 | Clinical and molecular aspects of multiple endocrine neoplasia. |
| Q28505581 | Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells |
| Q44059838 | Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation |
| Q40563939 | Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase |
| Q36191614 | Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. |
| Q37551897 | Conceptual Progress for the Improvements in the Selectivity and Efficacy of G Protein-Coupled Receptor Therapeutics: An Overview |
| Q103002031 | Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics |
| Q42482376 | Constitutively active mutants of the alpha(1a)- and the alpha(1b)-adrenergic receptor subtypes reveal coupling to different signaling pathways and physiological responses in rat cardiac myocytes |
| Q33280387 | Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells |
| Q40913280 | Correlation between Ca(2+) oscillation and cell proliferation via CCK(B)/gastrin receptor |
| Q40774080 | Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q |
| Q37383135 | Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells |
| Q44352220 | Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner |
| Q74121452 | Differential coupling of alpha1-adrenoreceptor subtypes to phospholipase C and mitogen activated protein kinase in neonatal rat cardiac myocytes |
| Q24534090 | Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement |
| Q30168727 | Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation |
| Q28572126 | Distinct signaling functions for Shc isoforms in the heart |
| Q73182919 | Dual effect of lysophosphatidic acid on proliferation of glomerular mesangial cells |
| Q73821815 | Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling |
| Q48404644 | Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons |
| Q73031500 | Endothelial cell mitogenesis induced by LPA: inhibition by thrombospondin-1 and thrombospondin-2 |
| Q34722259 | Endothelin-1 as a target for therapeutic intervention in prostate cancer |
| Q74298085 | Endothelin-1 production and agonist activities in cultured prostate-derived cells: implications for regulation of endothelin bioactivity and bioavailability in prostatic hyperplasia |
| Q73034846 | Epidermal growth factor activates extracellular signal-regulated protein kinases (ERK) in freshly isolated porcine granulosa cells |
| Q40975414 | Epidermal growth factor and angiotensin II regulation of extracellular signal-regulated protein kinase in rat liver epithelial WB cells |
| Q34118830 | Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer |
| Q41066099 | Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. |
| Q30452658 | Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo |
| Q24801822 | Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes |
| Q34181221 | G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation |
| Q39448110 | G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes |
| Q41655354 | G protein coupled receptors as modules of interacting proteins: a family meeting. |
| Q36819372 | G protein regulation of MAPK networks |
| Q28512542 | G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo |
| Q39455475 | G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals |
| Q33861227 | G protein-coupled receptors as targets for prolactin actions |
| Q73935044 | G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases |
| Q37607405 | G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells |
| Q41238078 | G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. |
| Q34296103 | G-protein-coupled receptors and signaling networks: emerging paradigms. |
| Q48255700 | GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries |
| Q40023907 | Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells |
| Q24318340 | Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation |
| Q39329751 | Genetic Background of Hirschsprung Disease: A Bridge Between Basic Science and Clinical Application. |
| Q41732769 | Genetic analysis of protein tyrosine phosphatases |
| Q44159321 | Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease |
| Q40944564 | Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes |
| Q44724822 | Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor |
| Q30176516 | Gi-mediated activation of the Ras/MAP kinase pathway involves a 100kDa tyrosine-phosphorylated Grb2 SH3 binding protein,but not Src nor Shc |
| Q34361286 | Glial cell responses to lipids bound to albumin in serum and plasma |
| Q43681027 | Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling |
| Q34028196 | Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors |
| Q41099712 | Heterotrimeric G proteins. |
| Q41621192 | Historical perspectives and new insights involving the MAP kinase cascades. |
| Q41204966 | Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway |
| Q30468240 | Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits |
| Q44884769 | Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation |
| Q40899387 | Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src. |
| Q33568659 | Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12. |
| Q40816727 | Insulin and insulin-like growth factor I receptors utilize different G protein signaling components |
| Q30168812 | Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation |
| Q24313171 | Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling |
| Q48829230 | Interaction of G protein Gbetagamma dimers with small GTP-binding proteins of the Rho family |
| Q38786279 | Interaction of Ras with p110γ is required for thymic β-selection in the mouse |
| Q28142400 | Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor |
| Q34115488 | Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents |
| Q42738024 | LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival |
| Q77436009 | Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation |
| Q36230241 | Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells |
| Q22337020 | Long-Term Potentiation and Memory |
| Q34130042 | Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas |
| Q28305859 | Lysophosphatidic acid: G-protein signalling and cellular responses |
| Q44473617 | MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle |
| Q35643898 | MEK1 expression and its relationship with clinical pathological features in hepatocellular carcinoma |
| Q24339513 | MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer |
| Q58435171 | Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 |
| Q58449882 | Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle |
| Q34397088 | Mechanisms of signal transduction activated by sublytic assembly of terminal complement complexes on nucleated cells |
| Q41107509 | Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? |
| Q37246892 | Mitochondria in cardiac hypertrophy and heart failure |
| Q24647045 | Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade |
| Q33997601 | Motility, survival, and proliferation |
| Q71324499 | Multiple intracellular MAP kinase signaling cascades |
| Q40864442 | Mutation of tyrosine 318 (Y318F) in the delta-opioid receptor attenuates tyrosine phosphorylation, agonist-dependent receptor internalization, and mitogen-activated protein kinase activation |
| Q42823221 | Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins. |
| Q28265064 | N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling |
| Q36693393 | NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion |
| Q41644952 | Neurotrophin activation of catecholamine storage vesicle protein gene expression: signaling to chromogranin a biosynthesis |
| Q34225939 | New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades |
| Q74016818 | Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors |
| Q93081308 | Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation |
| Q45111099 | Not so strange bedfellows: G-protein-coupled receptors and Src family kinases |
| Q30454375 | Novel form of crosstalk between G protein and tyrosine kinase pathways |
| Q34205602 | Oligomerization of G-protein-coupled transmitter receptors. |
| Q41190428 | Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway |
| Q33855336 | Opiate modulating properties of nociceptin/orphanin FQ. |
| Q57405393 | P1 and P2 receptors in cell growth and differentiation |
| Q42665155 | PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor |
| Q24292179 | PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis |
| Q42528944 | Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras. |
| Q43754619 | Parathyroid hormone activation of map kinase in rat duodenal cells is mediated by 3',5'-cyclic AMP and Ca(2+). |
| Q40906001 | Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor. |
| Q47688088 | Phagocyte chemoattractant receptors |
| Q41197935 | Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway |
| Q42799406 | Phosphatidylinositol 4,5-bisphosphate stimulates phosphorylation of the adaptor protein Shc by c-Src |
| Q44345034 | Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinase |
| Q44343456 | Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions. |
| Q42984582 | Phosphorylation and activation of p42 and p44 mitogen-activated protein kinase are required for the P2 purinoceptor stimulation of endothelial prostacyclin production |
| Q24313407 | Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits |
| Q42527926 | Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf |
| Q28609411 | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice |
| Q46359922 | Platelet-derived Growth Factor Activates a Mammalian Ste20 Coupled Mitogen-activated Protein Kinase in Airway Smooth Muscle |
| Q41838681 | Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase |
| Q77726430 | Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases |
| Q28281614 | Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression |
| Q28287882 | RGS10 is a selective activator of G alpha i GTPase activity |
| Q22008566 | RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11 |
| Q52568539 | RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells. |
| Q42159389 | Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades. |
| Q42451865 | Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor |
| Q34987415 | Ras as a target in cancer therapy |
| Q34225947 | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists |
| Q34160428 | Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a). |
| Q73541784 | Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase |
| Q41659022 | Ras-like GTPases |
| Q42807603 | Regulation by Gi2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3. |
| Q28115804 | Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors |
| Q73780899 | Regulation of mitogen-activated protein kinase pathways by catecholamine receptors |
| Q34467657 | Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. |
| Q71388077 | Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway |
| Q41647860 | Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors |
| Q33597362 | Regulation of tyrosine kinase cascades by G-protein-coupled receptors. |
| Q44944292 | Retinoic acid decreases fetal lung mesenchymal cell proliferation in vivo and in vitro |
| Q28266829 | Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors |
| Q35564914 | Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic Tissues |
| Q41745943 | Role of MAP kinase in neurons |
| Q41175767 | Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases |
| Q31574725 | Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone |
| Q37105461 | Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. |
| Q34437374 | Role of subunit diversity in signaling by heterotrimeric G proteins |
| Q42834837 | Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation |
| Q41492574 | Role of thromboxane A2 in mitogenesis of vascular smooth muscle cells. |
| Q41229236 | Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors |
| Q42829479 | Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway |
| Q44844132 | Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation |
| Q30167833 | SH2 and SH3 domains as targets for anti-proliferative agents |
| Q112999107 | SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 |
| Q44526164 | Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells |
| Q48826989 | Selective activation of effector pathways by brain-specific G protein beta5. |
| Q40973677 | Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis |
| Q46537484 | Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins |
| Q28609044 | Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP |
| Q41960343 | Signal characteristics of G protein-transactivated EGF receptor |
| Q40946565 | Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology |
| Q41260863 | Signal transduction pathways modulated by the D2 subfamily of dopamine receptors |
| Q41750250 | Signal transduction through MAP kinase cascades |
| Q50759062 | Signal transduction. Team blue sees red. |
| Q41135422 | Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling |
| Q77322545 | Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades |
| Q28199357 | Signaling via Shc family adapter proteins |
| Q41110511 | Signalling pathways: jack of all cascades |
| Q34397233 | Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum |
| Q38827518 | Somatostatin activates Ras and ERK1/2 via a G protein βγ-subunit-initiated pathway in thyroid cells. |
| Q34087763 | Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. |
| Q42411756 | Spatial signaling networks converge at the adaptor protein Shc. |
| Q42060867 | Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. |
| Q42799506 | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. |
| Q40969972 | Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase |
| Q28363296 | Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor |
| Q28140083 | Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1 |
| Q41291044 | Structure and function of proteins in G-protein-coupled signal transfer |
| Q27732196 | Structure and ligand recognition of the phosphotyrosine binding domain of Shc |
| Q41080173 | Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. |
| Q40865574 | Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades |
| Q34442841 | The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function |
| Q28609367 | The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium |
| Q43167668 | The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1. |
| Q37151146 | The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth |
| Q48063554 | The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium |
| Q33178125 | The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. |
| Q41022529 | The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium. |
| Q42982087 | The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle |
| Q23918126 | The effects of repetitive vibration on sensorineural function: biomarkers of sensorineural injury in an animal model of metabolic syndrome |
| Q40949649 | The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells |
| Q24562884 | The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes |
| Q46965251 | The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the β(1)-adrenergic receptor to G(s). |
| Q34034093 | The importance of being K-Ras |
| Q28181540 | The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor |
| Q33887177 | The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity |
| Q77343239 | The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas |
| Q41135262 | The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors |
| Q41788352 | The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells |
| Q37273521 | The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex |
| Q28583525 | The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores |
| Q36302328 | Transgenic Galphaq overexpression induces cardiac contractile failure in mice |
| Q41075127 | Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism. |
| Q24324018 | Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells |
| Q36363295 | Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment |
| Q41206249 | Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors |
| Q41080169 | Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone |
| Q33921584 | Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments |
| Q44332667 | Tyrosine phosphorylation of the delta-opioid receptor. Evidence for its role in mitogen-activated protein kinase activation and receptor internalization*. |
| Q31478590 | Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway |
| Q73038393 | beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytes |
| Q22253360 | beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2 |
| Q38310713 | mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization |
| Q40791937 | mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation |
| Q37453620 | β-adrenergic receptor responsiveness in aging heart and clinical implications |
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