Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.

scientific article

Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPGI.00440.2013
P932PMC publication ID4010651
P698PubMed publication ID24578342

P2093author name stringKarnam S Murthy
Sunila Mahavadi
Ancy D Nalli
Divya P Kumar
Jiean Huang
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RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunitsQ28287870
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Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinaseQ30661698
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Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscleQ34402242
G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthmaQ35772192
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Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinaseQ37629157
Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C.Q39891089
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.Q41080173
Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphQ41978159
Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathwayQ42138548
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Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptorsQ44308326
Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinaseQ44935032
Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle: dual requirement for alpha and beta gamma subunits of Gi3Q45081921
Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells.Q45112838
RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channelQ45145771
Tissue distribution and subcellular localization of a G-protein activated phosphoinositide 3-kinase. An immunohistochemical study.Q48380527
Coupling of M2 muscarinic receptors to membrane ion channels via phosphoinositide 3-kinase gamma and atypical protein kinase C.Q48918955
beta 2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or gbeta gamma in adult mouse cardiomyocytesQ73038393
Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscleQ74061131
The G-protein betagamma complexQ77354231
P433issue9
P921main subjectphosphorylationQ242736
P304page(s)G802-10
P577publication date2014-02-27
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleInhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.
P478volume306

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cites work (P2860)
Q92593093A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation
Q48118510Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
Q37062556Molecular Pharmacology of δ-Opioid Receptors
Q58613172Muscarinic m2 receptor-mediated actin polymerization via PI3 kinase γ and integrin-linked kinase in gastric smooth muscle
Q46160241RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression
Q38806373The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

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