An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension

scientific article published on April 1, 2003

An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJP.0705190
P953full work available at URLhttps://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705190
https://europepmc.org/articles/PMC1573786
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Fsj.bjp.0705190
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1038/sj.bjp.0705190
https://doi.org/10.1038/sj.bjp.0705190
https://europepmc.org/articles/PMC1573786?pdf=render
P932PMC publication ID1573786
P698PubMed publication ID12711632
P5875ResearchGate publication ID10789758

P50authorFiona MurrayQ62950891
Nigel J PyneQ64684063
P2093author name stringMargaret R. MacLean
P2860cites workphototransduction, visible lightQ14859550
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cellsQ28509420
Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertensionQ28567348
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathwayQ30193170
Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension?Q33709599
The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.Q34095262
Visual excitation and recoveryQ36652812
Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinasesQ38302601
ERK activation upon hypoxia: involvement in HIF-1 activationQ40898952
The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcriptsQ43955207
Combination therapy for pulmonary hypertension: a glimpse into the future?Q45080160
The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lungQ47959878
Etiology and pathogenesis of primary pulmonary hypertension: a perspectiveQ48767145
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertensionQ55670914
Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteriesQ73149687
Intracellular pathways linking hypoxia to activation of c-fos and AP-1Q73884995
Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteriesQ74235987
MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activationQ78252875
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
P304page(s)1313-1319
P577publication date2003-04-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAn assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension
An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension
P478volume138