mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization

scientific article published on July 2000

mu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0028-3908(99)00243-9
P698PubMed publication ID10884553

P2093author name stringSimon EJ
Kramer HK
P2860cites workRas-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinaseQ73541784
Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalizationQ77353622
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Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypesQ22009161
G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling ComplexesQ24324803
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitizationQ28276743
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Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin IQ28645568
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Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathwayQ30193170
Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsivenessQ36514037
Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidenceQ36824461
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunitsQ36982854
Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalizationQ37377196
Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes.Q39455257
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Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signalingQ40982696
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.Q41066099
Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonistQ41085743
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The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascadesQ41688659
A constitutively internalizing and recycling mutant of the mu-opioid receptor.Q42438949
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.Q42517406
Functional coupling of the delta-, mu-, and kappa-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells.Q44342434
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Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain.Q44347136
A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitizationQ44348585
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC.Q44351230
U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activationQ44351816
Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent mannerQ44352220
Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbol estersQ49011119
Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulationQ71070569
Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibitionQ71743487
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P433issue10
P1104number of pages13
P304page(s)1707-1719
P577publication date2000-07-01
P1433published inNeuropharmacologyQ15332439
P1476titlemu and delta-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization
P478volume39