Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

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Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia is …
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P819ADS bibcode2016PLoSO..1169159B
P356DOI10.1371/JOURNAL.PONE.0169159
P932PMC publication ID5201248
P698PubMed publication ID28036404

P50authorKatja ZirlikQ95969495
P2093author name stringMaike Buchner
Fabio Malavasi
Rainer Claus
Justus Duyster
Michael Reth
Arlette Dörffel
Christine Dierks
Hassan Jumaa
Hendrik Veelken
Kathrin Kläsener
Kerstin Leberecht
Marco Benkisser-Petersen
Marcus Dühren-von-Minden
Meike Burger
P2860cites workCD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survivalQ24328741
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemiaQ24599100
SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignanciesQ27690846
Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22Q28216101
An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemiaQ28257366
Targeting CD38 with Daratumumab Monotherapy in Multiple MyelomaQ28266655
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signallingQ28272891
Idelalisib and rituximab in relapsed chronic lymphocytic leukemiaQ28306347
Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsetsQ28545746
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase SykQ28619124
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaQ29620690
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated pQ30442865
CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cellsQ30484805
Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity.Q33690728
CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5.Q33725816
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemiaQ33873337
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.Q34060896
CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells.Q53336736
Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.Q53515550
CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleenQ57058811
CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cellsQ57374952
4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cellsQ57584301
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemiaQ58042064
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potentialQ61640131
CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transductionQ72201932
Biochemical analysis of activated T lymphocytes. Protein phosphorylation and Ras, ERK, and JNK activationQ73577797
Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathwayQ73644246
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironmentQ80837099
E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemiaQ83146478
Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9Q84094990
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.Q34156748
A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5Q36585953
Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptorQ38299456
The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells.Q39404177
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.Q39834162
CD38/CD19: a lipid raft-dependent signaling complex in human B cellsQ40165708
CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.Q40276341
CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs.Q40771031
Modulator and messenger functions of cyclic ADP-ribose in calcium signaling.Q41028995
CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinaseQ41103086
Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expressionQ41175199
CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinaseQ41254178
Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migrationQ42221150
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemiaQ43119715
Clinical significance of CD38 expression in chronic lymphocytic leukemiaQ43775864
CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?Q53322008
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)e0169159
P577publication date2016-12-30
P1433published inPLOS OneQ564954
P1476titleSpleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia
P478volume11