Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

scientific article

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020136644
P356DOI10.1186/AR3827
P932PMC publication ID3446479
P698PubMed publication ID22548780
P5875ResearchGate publication ID224878003

P50authorKatja LakotaQ82671666
P2093author name stringJungwha Lee
John Varga
Monique Hinchcliff
Jun Wei
Michael L Whitfield
Snezna Sodin-Semrl
Mary Carns
P2860cites workAdiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)Q28583520
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Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient miceQ32085363
Molecular subsets in the gene expression signatures of scleroderma skinQ33354088
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesisQ33745028
PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosisQ33799182
Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis.Q33950766
Criteria for the classification of early systemic sclerosis.Q34317138
Elevated adiponectin serum levels in women with systemic autoimmune diseasesQ34475777
Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosisQ35954579
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gammaQ37071874
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severityQ37402787
Transforming growth factor beta as a therapeutic target in systemic sclerosisQ37428739
Mechanisms of adiponectin regulation and use as a pharmacological targetQ37784586
Fibrosis and immune dysregulation in systemic sclerosisQ37791685
PPAR-gamma: adipogenic regulator and thiazolidinedione receptorQ41755813
Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gammaQ42459998
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived proteinQ42811136
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblastsQ43223419
The road from discovery to clinic: adiponectin as a biomarker of metabolic statusQ43241792
PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosisQ45285303
A prospective open-label study of mycophenolate mofetil for the treatment of diffuse systemic sclerosisQ45889664
Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis.Q51870089
Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients.Q54369365
Adiponectin and leptin up-regulate extracellular matrix production by dermal fibroblastsQ79818171
Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosusQ80038527
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosisQ84483475
Serum adipokine levels in patients with systemic lupus erythematosusQ84660768
P433issue3
P921main subjectbiomarkerQ864574
P304page(s)R102
P577publication date2012-05-01
P1433published inArthritis Research and TherapyQ15757229
P1476titleLevels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?
P478volume14

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cites work (P2860)
Q35623780A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis
Q42229072Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts
Q47110057Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice
Q33860888Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.
Q58797878An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis
Q39450087An update on biomarker discovery and use in systemic sclerosis.
Q51385249Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis.
Q38771824Biomarkers in Scleroderma: Progressing from Association to Clinical Utility
Q54776294Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-β1.
Q33736823Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis
Q92104501Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis
Q38156227Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development
Q37395851Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis
Q37227633Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis
Q38708686Elevated Adipsin Levels are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis
Q47109594Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis
Q54162257Meta-analysis of circulating adiponectin, leptin, and resistin levels in systemic sclerosis.
Q55490826Novel classification for global gene signature model for predicting severity of systemic sclerosis.
Q38164818Novel investigational agents for the treatment of scleroderma
Q45975840Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.
Q37227987Peroxisome proliferator-activated receptor-γ agonist troglitazone suppresses transforming growth factor-β1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro
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Q39671627Serum adipokines levels in patients with systemic sclerosis: A meta-analysis
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Q53580852Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis.
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Q38524619The Role of PPAR Gamma in Systemic Sclerosis
Q36633255The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy
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Q47095125Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma
Q38922023Validation of Serbian version of UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument in 104 patients with systemic sclerosis
Q38141638What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis?

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