Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease

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Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease is …
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P819ADS bibcode2017PLoSO..1269892K
P356DOI10.1371/JOURNAL.PONE.0169892
P932PMC publication ID5231331
P698PubMed publication ID28081260

P50authorJochen BlomQ88525311
Matthias FroschQ1795407
Alexander GoesmannQ52422599
Johanna KlughammerQ58166380
Christoph SchoenQ58191388
P2093author name stringTobias Müller
Ulrich Vogel
Marcus Dittrich
Vera Mitesser
P2860cites workGenBankQ84894623
Bioconductor: open software development for computational biology and bioinformaticsQ21194861
BLAST+: architecture and applicationsQ21284368
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The TIGRFAMs database of protein familiesQ24681677
Basic local alignment search toolQ25938991
Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cellsQ27334765
Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse modelQ27336577
Fast gapped-read alignment with Bowtie 2Q27860699
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The Sequence Alignment/Map format and SAMtoolsQ27860966
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Meningococcal carriage and disease--population biology and evolutionQ28246008
Slipped-strand mispairing: a major mechanism for DNA sequence evolutionQ28295992
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infectionQ28534306
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The evolution and maintenance of virulence in microparasitesQ28755460
SignalP 4.0: discriminating signal peptides from transmembrane regionsQ29547202
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UniProt: a hub for protein informationQ29547457
Prodigal: prokaryotic gene recognition and translation initiation site identificationQ29547611
The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'.Q33245141
Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.Q33274203
Phasevarions mediate random switching of gene expression in pathogenic NeisseriaQ33434451
Complete Genome Sequence of Neisseria meningitidis Serogroup A Strain NMA510612, Isolated from a Patient with Bacterial Meningitis in ChinaQ33584672
Phase variation mediates reductions in expression of surface proteins during persistent meningococcal carriageQ33603065
Genome sequencing reveals widespread virulence gene exchange among human Neisseria speciesQ33646735
Necessity of molecular techniques to distinguish between Neisseria meningitidis strains isolated from patients with meningococcal disease and from their healthy contactsQ33681356
Genotypic and phenotypic modifications of Neisseria meningitidis after an accidental human passageQ33840768
Rates of mutation and host transmission for an Escherichia coli clone over 3 yearsQ34064804
Metabolism and virulence in Neisseria meningitidisQ34068118
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombinationQ34168120
Sequencing depth and coverage: key considerations in genomic analysesQ34398440
Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis.Q34470436
Attachment and invasion of Neisseria meningitidis to host cells is related to surface hydrophobicity, bacterial cell size and capsuleQ34584506
Epidemic meningitis, meningococcaemia, and Neisseria meningitidisQ34644525
Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidisQ34836342
Comparative genomics: the bacterial pan-genomeQ34905107
The distribution and 'in vivo' phase variation status of haemoglobin receptors in invasive meningococcal serogroup B disease: genotypic and phenotypic analysisQ35010428
Iron transport systems in Neisseria meningitidisQ35684980
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to diseaseQ35849727
In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.Q36177419
Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidisQ36253028
A functional two-partner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cellsQ36314792
Purification and characterization of eight class 5 outer membrane protein variants from a clone of Neisseria meningitidis serogroup A.Q36355197
Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidisQ36491155
Broad conditions favor the evolution of phase-variable loci.Q36537965
Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptationQ36649037
Lessons from meningococcal carriage studiesQ36711465
Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cellsQ37467707
Epidemiological and clinical consequences of within-host evolutionQ37807625
Mechanisms of meningococcal colonisationQ37911686
Evolution of virulence in opportunistic pathogens: generalism, plasticity, and controlQ38008037
Genetic susceptibility to meningococcal infectionQ38081495
Invasive meningococcal disease: a disease of the endothelial cellsQ38245296
The genetics of Neisseria speciesQ38253932
Functional characterization of an isogenic meningococcal alpha-2,3-sialyltransferase mutant: the role of lipooligosaccharide sialylation for serum resistance in serogroup B meningococciQ38341389
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins.Q38342126
Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis.Q38342290
Polymorphisms in pilin glycosylation Locus of Neisseria meningitidis expressing class II pili.Q39520354
Posttranslational modification of pili upon cell contact triggers N. meningitidis disseminationQ39594338
Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulenceQ39667409
GenDB--an open source genome annotation system for prokaryote genomesQ39747829
Improved detection of helix-turn-helix DNA-binding motifs in protein sequencesQ40523295
Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive diseaseQ40595205
ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.Q40721549
Short-sighted evolution and the virulence of pathogenic microorganismsQ40739465
Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assemblyQ41079923
Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594.Q41971567
Meningococcal interaction to microvasculature triggers the tissular lesions of purpura fulminansQ42255763
Impact of Moderate Temperature Changes on Neisseria meningitidis Adhesion Phenotypes and Proteome.Q42365570
Mismatch repair and the regulation of phase variation in Neisseria meningitidisQ43612705
The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidisQ44964045
School-based clusters of meningococcal disease in the United States. Descriptive epidemiology and a case-control analysisQ45003008
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone.Q50857953
Epidemiology, hypermutation, within-host evolution and the virulence of Neisseria meningitidis.Q52009449
Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58Q57976193
Neisseria PilC protein identified as type-4 pilus tip-located adhesinQ59097833
Antigenic Cross-reactivity of Neisseria Pili: Investigations with Type- and Species-specific Monoclonal AntibodiesQ64451715
A permanent heteroploid human cell line with type B glucose-6-phosphate dehydrogenaseQ71782728
Whole blood model of meningococcal bacteraemia--a method for exploring host-bacterial interactionsQ71980025
Phase variation of the gonococcal siderophore receptor FetAQ73873718
Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria sppQ74339153
Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variationQ79079901
Within-host evolution for the invasiveness of commensal bacteria: an experimental study of bacteremias resulting from Haemophilus influenzae nasal carriageQ80973926
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinvasive diseaseQ111796726
Neisseria meningitidisQ154625
mutationQ42918
P304page(s)e0169892
P577publication date2017-01-12
P1433published inPLOS OneQ564954
P1476titleComparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease
P478volume12

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Q44068860Genomic, Transcriptomic, and Phenotypic Analyses of Neisseria meningitidis Isolates from Disease Patients and Their Household Contacts.
Q52648036Genotypic and phenotypic characterization of the O-linked protein glycosylation system reveals high glycan diversity in paired meningococcal carriage isolates.
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