Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice

scientific article

Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.5114/CEJI.2015.52826
P932PMC publication ID4637387
P698PubMed publication ID26557026
P5875ResearchGate publication ID282739958

P50authorRenxi WangQ59677235
Yinxiang WeiQ85371355
Gencheng HanQ88750898
Guojiang ChenQ120564554
Beifen ShenQ120564569
Chunmei HouQ120564954
P2093author name stringYan Li
Xiaoling Liu
He Xiao
Xiaoqian Wang
P2860cites workTACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune diseaseQ22254041
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphomaQ24646563
Antiviral CD4+ memory T cells are IL-15 dependentQ24676283
The role of the BAFF/APRIL system on T cell functionQ28259870
Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosusQ33928629
BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitisQ34012753
BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosusQ34245983
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.Q34579440
Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis.Q34809963
IL-15 is a growth factor and an activator of CD8 memory T cellsQ35049746
Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic miceQ35110335
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestationsQ36375661
An APRIL to remember: novel TNF ligands as therapeutic targetsQ36394955
Taming lupus-a new understanding of pathogenesis is leading to clinical advancesQ36712941
Cracking the BAFF code.Q37517172
Memory B and memory plasma cellsQ37781393
Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse modelQ40156550
Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac diseaseQ40638913
hsBAFF regulates proliferation and response in cultured CD4(+) T lymphocytes by upregulation of intracellular free Ca(2+) homeostasisQ43957984
Active induction of experimental allergic encephalomyelitisQ48175463
Combination of TACI-IgG and anti-IL-15 treats murine lupus by reducing mature and memory B cells.Q50850569
BAFF suppresses IL-15 expression in B cells.Q50855805
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte lossQ58425792
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLySQ74419758
Nonclinical safety, pharmacokinetics, and pharmacodynamics of ataciceptQ81394138
Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 miceQ83230096
BAFF induces spleen CD4+ T cell proliferation by down-regulating phosphorylation of FOXO3A and activates cyclin D2 and D3 expressionQ84811169
TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with adjuvant-induced arthritisQ85090315
P433issue2
P304page(s)142-148
P577publication date2015-08-03
P1433published inCentral-European Journal of ImmunologyQ15764592
P1476titleBlockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice
P478volume40

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cites work (P2860)
Q38961202B Cell-Activating Factor (BAFF)-Targeted B Cell Therapies in Inflammatory Bowel Diseases.
Q52577393Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis.
Q41594953Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis
Q92302527The role of B cells in multiple sclerosis: Current and future therapies

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