BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis

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BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...623629Z
P356DOI10.1371/JOURNAL.PONE.0023629
P932PMC publication ID3163640
P698PubMed publication ID21897850
P5875ResearchGate publication ID51625037

P50authorJulie WangQ89552243
P2093author name stringXiaohui Zhou
Zhongmin Liu
Zanxian Xia
William Stohl
Wenru Su
Huimin Fan
Yuan-Ping Han
Song Guo Zheng
Qin Lan
P2860cites workBAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growthQ22009942
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune diseaseQ22254041
The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribedQ24311586
NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamilyQ24314630
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphomaQ24646563
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2Q27639845
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulatorQ28139180
Characterization of a new member of the TNF family expressed on antigen presenting cellsQ28144198
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiencyQ28190857
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFFQ28213294
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILQ28216755
STAT3 regulates cytokine-mediated generation of inflammatory helper T cellsQ28286840
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trialQ28304807
B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cellsQ28590517
Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritisQ30484091
Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosusQ33928629
Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.Q33951524
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent PathwayQ57230082
Synthesis and release of B-lymphocyte stimulator from myeloid cellsQ73335981
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in miceQ74108088
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLySQ74419758
BAFF is a survival and maturation factor for mouse B cellsQ74456240
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient miceQ79317500
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritisQ80340621
Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytesQ82132578
Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plotQ33999367
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeQ34108411
Similarities and differences between selective and nonselective BAFF blockade in murine SLEQ34350295
Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosusQ34802966
Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cellsQ34927437
Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu.Q34994485
Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic miceQ35110335
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell populationQ35834649
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.Q36229199
Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune responseQ36368953
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestationsQ36375661
TACI and BAFF-R mediate isotype switching in B cellsQ36402479
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunityQ36983608
B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturationQ37009908
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in miceQ37036086
A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosusQ37378350
Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, LoucyQ40272900
G-CSF-stimulated neutrophils are a prominent source of functional BLySQ41818295
Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cellsQ42079747
A role for BLyS in the activation of innate immune cellsQ42742005
In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitisQ42876667
BAFF mediates survival of peripheral immature B lymphocytesQ42944182
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndromeQ43050637
Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitisQ43208021
T cell costimulation by the TNF ligand BAFF.Q43803679
A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responsesQ45302161
Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.Q45998381
B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations.Q46001110
Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosisQ47274470
BAFF augments certain Th1-associated inflammatory responses.Q47810975
B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitizationQ48364459
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectexperimental autoimmune encephalomyelitisQ494066
P304page(s)e23629
P577publication date2011-08-29
P1433published inPLOS OneQ564954
P1476titleBAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis
P478volume6

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cites work (P2860)
Q52885446A Novel BLyS Peptibody Down-Regulates B Cell and T Helper Cell Subsets In Vivo and Ameliorates Collagen-Induced Arthritis.
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Q46733493B cell activating factor and T-helper 17 cells: possible synergistic culprits in the pathogenesis of Alopecia Areata
Q48195816BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis.
Q38006643Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development?
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Q36421539Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice
Q34785104Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses
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Q51108455TACI-dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus.
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Q35986113Treatment of systemic lupus erythematosus patients with the BAFF antagonist "peptibody" blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials.
Q44219240VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis.

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