Clinical targeting of the TNF and TNFR superfamilies

scientific article published on 21 January 2013

Clinical targeting of the TNF and TNFR superfamilies is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NRD3930
P932PMC publication ID3625401
P698PubMed publication ID23334208

P2093author name stringMichael Croft
Carl F Ware
Chris A Benedict
P2860cites workDenosumab-mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patientsQ84062765
Upregulation and nuclear localization of TNF‐like Cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesionsQ84358114
Efficacy and safety of tanezumab in the treatment of chronic low back painQ84421146
SOX40L: an important inflammatory mediator in adult bronchial asthmaQ84516949
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosisQ24293476
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemiaQ24594920
Atacicept: targeting B cells in multiple sclerosisQ24628925
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemiaQ24632975
Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRILQ24681342
Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplantsQ24685457
Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritisQ81895285
Clinical association of serum CD137 (4-1BB) levels in patients with systemic sclerosisQ82220201
A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignanciesQ82489143
Preclinical characterization of SGN-70, a humanized antibody directed against CD70Q82791833
A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignanciesQ82847250
Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patientQ82901856
Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cellsQ83169803
TNFSF9 expression in primary biliary cirrhosis and its clinical significanceQ83372673
The involvement of epithelial Fas in a human model of graft versus host diseaseQ83610928
Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trialQ83753641
Phase I Study of Atacicept in Relapsed/Refractory Multiple Myeloma (MM) and Waldenström's MacroglobulinemiaQ83757871
Anti-NGF painkillers back on track?Q84032456
A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapyQ84056960
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trialQ78667363
Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic studyQ79298134
Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's diseaseQ80360895
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic miceQ80733397
Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockadeQ80768340
OX40 (CD134) expression in sentinel lymph nodes correlates with prognostic features of primary melanomasQ80977921
Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's diseaseQ81640268
Targeting the LIGHT-HVEM pathwayQ37598573
Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseasesQ37598579
Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) Receptor-1 and Receptor-2 agonists for cancer therapyQ37621564
Novel functions of RANK(L) signaling in the immune systemQ37641877
Tumor necrosis factor receptor/tumor necrosis factor family members in antiviral CD8 T-cell immunityQ37727208
Glucocorticoid‐Induced TNFR‐Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic ModulationQ37799255
Insights into TL1A and IBD PathogenesisQ37820354
Anti-GITR antibodies--potential clinical applications for tumor immunotherapyQ37820485
Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.Q37835892
Therapeutic targeting of CD95 and the TRAIL death receptorsQ37901478
Conatumumab: a novel monoclonal antibody against death receptor 5 for the treatment of advanced malignancies in adultsQ37923958
The role of core TNF/LIGHT family members in lymph node homeostasis and remodelingQ37948122
OX40 and CD30 signals in CD4+ T‐cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T‐cell memory but not effector functionQ37948124
T‐cell intrinsic effects of GITR and 4‐1BB during viral infection and cancer immunotherapyQ37948129
TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapiesQ37974875
The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases; focus on inflammatory bowel diseasesQ38016615
Role of TWEAK in lupus nephritis: A bench-to-bedside reviewQ38021183
Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers.Q38332777
Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cellsQ38345998
Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40.Q38464262
Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled studyQ38482622
Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee painQ38495635
The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft modelsQ39336527
Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activityQ39381907
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomasQ39547912
Long-Term Hepatic Allograft Acceptance Based on CD40 Blockade by ASKP1240 in Nonhuman PrimatesQ39640425
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organQ39723178
Combining radiotherapy with APO010 in cancer treatmentQ39874751
Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritisQ39882954
Comparative analysis of the expression patterns of various TNFSF/TNFRSF in atherosclerotic plaquesQ39969894
Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritisQ40119794
Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritisQ40159370
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activitiesQ40220612
Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myelomaQ40402220
B-cell-derived lymphotoxin promotes castration-resistant prostate cancerQ40440899
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.Q40456758
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.Q40459668
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implicationsQ40566183
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantationQ40578442
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia.Q40590332
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer modelQ40632094
Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancersQ40880445
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathwayQ40896166
Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumour activity against CD30+ tumour cells in vitro and in SCID miceQ40949241
APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 responseQ42574976
In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-DiseaseQ27307168
Etanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trialQ28202166
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Constitutive Expression of LIGHT on T Cells Leads to Lymphocyte Activation, Inflammation, and Tissue DestructionQ28206179
Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?Q28207052
A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosusQ28254310
Denosumab for prevention of fractures in postmenopausal women with osteoporosisQ28254528
TACI is mutant in common variable immunodeficiency and IgA deficiencyQ28260786
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumabQ28265584
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trialQ28304807
APRIL-deficient mice have normal immune system developmentQ28511017
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humansQ29614348
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2Q29620608
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412Q29622893
B Cell Maturation Antigen Deficiency Exacerbates Lymphoproliferation and Autoimmunity in Murine LupusQ30426692
TWEAK/Fn14 pathway: an immunological switch for shaping tissue responsesQ33352379
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated miceQ33374623
The effect of anti-CD40 ligand in immune thrombocytopenic purpuraQ33378961
Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancerQ33397708
A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancerQ33401816
A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicityQ33586493
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancerQ33658593
An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer CellsQ33798802
A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myelomaQ33829132
Control of immunity by the TNFR-related molecule OX40 (CD134)Q33899607
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine liversQ34001849
BAFF Promotes Th17 Cells and Aggravates Experimental Autoimmune EncephalomyelitisQ34012753
Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailabilityQ34065607
The molecular architecture of the TNF superfamilyQ34109796
Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody–drug conjugate SGN-75Q34122802
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptorQ34178508
cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activityQ34192806
The many roles of FAS receptor signaling in the immune systemQ34205697
Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphismQ34231085
Accelerated central nervous system autoimmunity in BAFF-receptor-deficient miceQ34231528
CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic miceQ36697649
TRAIL death receptors and cancer therapeuticsQ36714168
Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphomaQ36822162
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.Q36835864
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanomaQ37014061
Tumor necrosis factor antagonist mechanisms of action: a comprehensive reviewQ37043901
The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targetingQ37135363
Targeting tumors with LIGHT to generate metastasis-clearing immunityQ37175025
Inhibition of the lymphotoxin pathway as a therapy for autoimmune diseaseQ37211265
Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL).Q37221909
Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemiaQ37257024
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.Q37262424
TNF superfamily: costimulation and clinical applicationsQ37266849
The role of TNF superfamily members in T-cell function and diseasesQ37332068
The BLyS family: toward a molecular understanding of B cell homeostasisQ37335169
Origins and functional basis of regulatory CD11c+CD8+ T cellsQ37356106
The risk of infections with biologic therapies for rheumatoid arthritisQ37360691
CD40 and autoimmunity: the dark side of a great activator.Q37365433
Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: a phase I studyQ37400568
TL1A and DR3, a TNF family ligand‐receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammationQ37438611
Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathologyQ37474941
Cracking the BAFF code.Q37517172
CD95, BIM and T cell homeostasisQ37526364
Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanismsQ42830477
Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's diseaseQ43416020
The effect of a single dose of osteoprotegerin in postmenopausal womenQ43520860
Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune diseaseQ44118287
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastasesQ44291815
Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and MetastasisQ44486779
4-1BB-mediated immunotherapy of rheumatoid arthritis.Q45078356
Blocking the effects of NGF as a route to safe and effective pain relief – fact or fancy?Q45162445
Safety, pharmacokinetics and pharmacodynamics of atacicept in healthy volunteersQ45164056
A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responsesQ45302161
Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trialQ46071397
Tanezumab for the Treatment of Pain from Osteoarthritis of the KneeQ46259879
Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trialQ46353641
Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritisQ46624594
Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugatesQ46952775
Serum OX40 ligand levels in asthmatic children: A potential biomarker of severity and persistenceQ46978639
A Phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma.Q47731944
Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemiaQ47758962
Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritisQ47923806
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2.Q48851709
Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE.Q48892230
Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A geneQ50482693
Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysisQ50484870
Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III TrialQ51326054
First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: a phase I/II open-label and double-blind studyQ51452174
Development, validation and application of ELISAs for pharmacokinetic and HACA assessment of a chimeric anti-CD40 monoclonal antibody in human serumQ51771655
A phase II study of SGN-30 in cutaneous anaplastic large cell lymphoma and related lymphoproliferative disordersQ51789300
Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.Q51966554
A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemiaQ53351927
Phase I clinical study of atacicept in patients with relapsed and refractory B-cell non-Hodgkin's lymphomaQ53497567
Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134).Q53669679
Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitisQ54350603
TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune SystemQ57184195
High serum levels of B-lymphocyte stimulator are associated with clinical?pathological features and outcome in classical Hodgkin lymphomaQ58883556
Increased Soluble 4-1BB Ligand (4-1BBL) Levels in Peripheral Blood of Patients with Multiple SclerosisQ60187909
Response of refractory Hodgkin's disease to monoclonal anti-CD30 immunotoxinQ67516432
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritisQ73114791
Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primatesQ73134598
Thromboembolic complications after treatment with monoclonal antibody against CD40 ligandQ73401367
A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primatesQ73458018
Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosusQ73483737
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effectQ73785060
A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritisQ74251717
The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's diseaseQ74409841
Expansile Skeletal Hyperphosphatasia Is Caused by a 15-Base Pair Tandem Duplication inTNFRSF11AEncoding RANK and Is Allelic to Familial Expansile OsteolysisQ77435071
Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host diseaseQ77849981
TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis GroupQ78130683
LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signalingQ34382093
A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphomaQ34433792
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapyQ34571305
Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumorsQ34616576
Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cellsQ34633278
Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophagesQ34643967
APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivoQ34722539
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progressionQ34831296
The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodelingQ34989767
Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challengesQ35003473
Tumor necrosis factor blockade and the risk of viral infectionQ35161630
The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious DiseasesQ35172090
Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primatesQ35546416
Development of an Fn14 agonistic antibody as an anti-tumor agentQ35556794
TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)Q35567956
A lymphotoxin-driven pathway to hepatocellular carcinomaQ35575883
Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trialQ35638718
The TWEAK-Fn14 System: Breaking the Silence of Cytokine-Induced Skeletal Muscle WastingQ35671234
The discovery and development of belimumab: the anti-BLyS–lupus connectionQ35691272
Dispensability of APRIL to the development of systemic lupus erythematosus in NZM 2328 miceQ35798968
TNF superfamily in inflammatory disease: translating basic insightsQ35821666
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin diseaseQ36007685
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulationQ36053977
Network communications: lymphotoxins, LIGHT, and TNF.Q36072461
Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trialQ36084891
Pharmacological modulation of GITRL/GITR system: therapeutic perspectives.Q36147260
Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the first two years of the FREEDOM extensionQ36153179
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammationQ36173559
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growthQ36368318
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammationQ36371325
Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trialQ36508404
A phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignanciesQ36508806
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb.Q36546646
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectTNFQ18032037
P304page(s)147-168
P577publication date2013-01-21
P13046publication type of scholarly workreview articleQ7318358
P1433published inNature Reviews Drug DiscoveryQ45998
P1476titleClinical targeting of the TNF and TNFR superfamilies
P478volume12

Reverse relations

cites work (P2860)
Q270129634-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity
Q896361324-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis
Q36342596A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo
Q27303179A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury.
Q64125373A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes
Q38593164A three-signal model of T-cell lymphoma pathogenesis
Q36317314A transcriptome multi-tissue analysis identifies biological pathways and genes associated with variations in feed efficiency of growing pigs
Q42378925A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members
Q41686962Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format.
Q50907965Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway
Q51786117Antibody-cytokine fusion proteins for cancer immunotherapy: an update on recent developments
Q47111511Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis
Q35608058Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation
Q38177749Behçet's syndrome pathophysiology and potential therapeutic targets
Q38748557Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
Q39032610Building proteomic tool boxes to monitor MHC class I and class II peptides
Q38577294CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.
Q47242631CD70 encoded by modified vaccinia virus Ankara enhances CD8 T cell dependent protective immunity in MHC class II-deficient mice.
Q90196777Catching a complex for optimal signaling
Q55174819Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds.
Q94545262Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF
Q93369638Combined therapy using LHRH-PE40 and anti-CD40 dendritic cells substantially eliminate tumor cells
Q52342639Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Q37723095Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
Q95282533Coronavirus Disease 2019-related dyspnea cases difficult to interpret using chest computed tomography
Q35599724Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function
Q64087049Cortistatin binds to TNF-α receptors and protects against osteoarthritis
Q47292379Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
Q48315643Current Pharmacologic Approaches in Painful Bladder Research: An Update.
Q39028574Cytokines IL-17 and IL-22 in the host response to infection
Q92381600Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses
Q88643533Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction
Q59354378Distinct Changes of BTLA and HVEM Expressions in Circulating CD4 and CD8 T Cells in Hepatocellular Carcinoma Patients
Q37033724Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.
Q54353561Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival
Q58804320Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans
Q35019555Ensemble of gene signatures identifies novel biomarkers in colorectal cancer activated through PPARγ and TNFα signaling
Q48632619Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells
Q35279021Evaluation of the Effects of Some Brazilian Medicinal Plants on the Production of TNF- α and CCL2 by THP-1 Cells.
Q90638896Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
Q95306567Exemplifying complexity of immune suppression by a 'canonical' speech: A glimpse into TNFRSF-activated signaling pathways in Treg cells
Q37003881Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo
Q41192295Functional Detection of TNF Receptor Family Members by Affinity-Labeled Ligands
Q28656460Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies
Q35880618Haematological malignancies: at the forefront of immunotherapeutic innovation
Q90212766Harnessing the immune system via FcγR function in immune therapy: A pathway to next-gen mAbs
Q26745544How Mouse Macrophages Sense What Is Going On.
Q48138391Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement.
Q37500368Human and mouse CD137 have predominantly different binding CRDs to their respective ligands
Q38306150Immune checkpoint combinations from mouse to man.
Q37138965Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells
Q92461421Immunotherapy in colorectal cancer: rationale, challenges and potential
Q27005445Inflammatory pathways of importance for management of inflammatory bowel disease
Q26772080Influence of immunoglobulin isotype on therapeutic antibody function
Q38985676Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases.
Q41495773Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis
Q37392885Intricacies for posttranslational tumor-targeted cytokine gene therapy
Q42152396Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype.
Q47250561Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives.
Q39245218Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy.
Q42152414Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.
Q47787256MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Q37424545Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events
Q38966698Molecular signaling cascades involved in nonmelanoma skin carcinogenesis
Q38116065Monoclonal antibody treatments for rheumatoid arthritis
Q48228066Murinization and H Chain Isotype Matching of the Anti-GITR Antibody DTA-1 Reduces Immunogenicity-Mediated Anaphylaxis in C57BL/6 Mice.
Q28078448NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?
Q30832764NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor.
Q90167531New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)
Q35612396Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.
Q40432376OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection.
Q41643876OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans
Q51041005Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production
Q38241526Outflanking RANK with a designer antagonist cytokine
Q34518822Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity
Q52316229Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy.
Q36231756Peripheral Organs of Dengue Fatal Cases Present Strong Pro-Inflammatory Response with Participation of IFN-Gamma-, TNF-Alpha- and RANTES-Producing Cells
Q34465302Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts
Q34025881Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare
Q90505852Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Q48174470Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand
Q46186295RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1.
Q55255265RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway.
Q99616637Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials
Q28262381Regulation of tumour necrosis factor signalling: live or let die
Q44000801Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.
Q38202988Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation
Q38900838Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling
Q26800155Role of Tumor Necrosis Factor Superfamily in Neuroinflammation and Autoimmunity
Q58739958Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis
Q38834775Roles of extracellular nucleotides and P2 receptors in ectodomain shedding
Q38764224SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes
Q41769678Salivary and serum biomarkers for the study of side effects of aripiprazole coprescribed with mirtazapine in rats
Q47661976Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction
Q34954124Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction
Q41057098Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling
Q42776887T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.
Q33920121T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway
Q36292332TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB
Q37433321TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Q38241605TNF receptors: signaling pathways and contribution to renal dysfunction
Q35534271TNF superfamily protein-protein interactions: feasibility of small- molecule modulation
Q38124483TNF-α signaling in Fanconi anemia
Q42259539TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model
Q54321573TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Q64266102TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?
Q33860715TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.
Q37111489Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network
Q26740179Targeting T cells to treat atherosclerosis: odyssey from bench to bedside
Q33613493Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs
Q40075590Targeting methionine cycle as a potential therapeutic strategy for immune disorders.
Q38120535Targeting of the Tumor Necrosis Factor Receptor Superfamily for Cancer Immunotherapy
Q92475952Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Q27025082The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity
Q38811689The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice
Q36940326The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses
Q38194782The TNF family in T cell differentiation and function--unanswered questions and future directions
Q35858686The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis
Q38669228The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes.
Q38550407The life (and death) of CD4+ CD28(null) T cells in inflammatory diseases
Q38237315The mechanisms and applications of T cell vaccination for autoimmune diseases: a comprehensive review
Q50420098The peptide lycosin-I attenuates TNF-α-induced inflammation in human umbilical vein endothelial cells via IκB/NF-κB signaling pathway
Q92916933The promise of CD4+FoxP3+ regulatory T-cell manipulation in vivo: applications for allogeneic hematopoietic stem cell transplantation
Q36958902Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases
Q38174792Therapeutic opportunities of the IL-22-IL-22R1 system
Q88922346Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions
Q57295884Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity
Q48158819Transcription factor RBP-J-mediated signalling regulates basophil immunoregulatory function in mouse asthma model.
Q34146626Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines
Q34233871Transient TNF regulates the self-renewing capacity of stem-like label-retaining cells in sphere and skin equivalent models of melanoma
Q38705509Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
Q40645815Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions
Q89506076Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB
Q35941021Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis
Q26829390Tumor necrosis factor-α inhibitors and chronic hepatitis C: a comprehensive literature review
Q47325439Tumor-targeted costimulation with antibody-fusion proteins improves bispecific antibody-mediated immune response in presence of immunosuppressive factors.
Q52538370Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.
Q38769021Vaccines for established cancer: overcoming the challenges posed by immune evasion
Q64905539[Biologics in Rhinology - Forthcoming Personalized Concepts: the Future Starts Today].
Q87361367[Immunomodulation as innovative therapy for head and neck tumors : Current developments]
Q35814239γ-Secretase directly sheds the survival receptor BCMA from plasma cells