Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity

scientific article

Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00262-012-1237-1
P698PubMed publication ID22406983
P5875ResearchGate publication ID221692988

P50authorTheodore OliphantQ81871283
P2093author name stringSimon Bergqvist
Regis Doyonnas
Amy C Shen
Paul D Lira
Timothy S Fisher
Sharon A Sokolowski
Sangita M Baxi
Cris Kamperschroer
Chunli Huang
Leslie L Sharp
Allison Rohner
Victoria A Love
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Immune Modulation through 4-1BB Enhances SIV Vaccine Protection in Non-Human Primates against SIVmac251 ChallengeQ28740359
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humansQ29614348
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A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicityQ33586493
In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)Q34073529
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Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumorsQ34616576
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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotypeQ35828831
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Genes that distinguish physiological and pathological angiogenesisQ36087324
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.Q36183600
Dual immunoregulatory pathways of 4-1BB signalingQ36573413
Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signalingQ36797904
The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancerQ37118182
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Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulationQ37422374
Immune regulation by 4-1BB and 4-1BBL: complexities and challengesQ37474935
Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathwaysQ37768063
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Cancer immunotherapy – revisitedQ37908998
Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 AntibodiesQ38275268
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.Q39602916
Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.Q39724400
ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivoQ39975642
Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chainQ40605275
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivoQ42938990
Cloning, expression and characterization of monkey (Macaca fascicularis) CD137.Q44965339
Development and Homeostasis of T Cell Memory in Rhesus MacaqueQ45882091
4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responsesQ51996548
Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibodyQ53234389
Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphomaQ53344642
Ipilimumab.Q55054369
Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemiaQ58043051
P433issue10
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
cell functionQ95674809
P304page(s)1721-1733
P577publication date2012-03-11
P1433published inCancer Immunology, ImmunotherapyQ5031409
P1476titleTargeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
P478volume61

Reverse relations

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