Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

scientific article

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1056/NEJMOA1103849
P3181OpenCitations bibliographic resource ID759426
P932PMC publication ID3387277
P698PubMed publication ID21830940

P50authorBruce L. LevineQ85544154
David L. PorterQ110797660
Carl H. JuneQ19277113
P2093author name stringAdam Bagg
Michael Kalos
P2860cites workControl of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.Q37117781
Stem cell transplantation for indolent lymphoma and chronic lymphocytic leukemiaQ37824996
Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia.Q39215504
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathwaysQ41691499
CARs on track in the clinicQ42649114
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trialQ42797321
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivoQ42938990
A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.Q53650474
Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxinsQ68090182
p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemiasQ72626720
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigenQ24623215
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemiaQ24632975
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2Q29620608
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastomaQ29622835
Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in miceQ30493889
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptorQ34122292
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificityQ34326400
Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.Q34422330
The promise and potential pitfalls of chimeric antigen receptorsQ34970378
Acute tumor lysis syndrome in solid tumors--a case report and review of the literatureQ35091521
Engineering lymphocyte subsets: tools, trials and tribulationsQ36140986
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancerQ36299662
Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemiaQ36384668
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cellsQ36868712
Immunological aspects of cancer chemotherapyQ37039588
A decade of rituximab: improving survival outcomes in non-Hodgkin's lymphomaQ37054400
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
lymphoid leukemiaQ6708277
lymphoblastic leukemiaQ18553852
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)725-33
P577publication date2011-08-25
P1433published inThe New England Journal of MedicineQ582728
P1476titleChimeric antigen receptor-modified T cells in chronic lymphoid leukemia
P478volume365

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Q29620607CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
Q28084879CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
Q92039571CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
Q38371387CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia
Q38064963CD19: a biomarker for B cell development, lymphoma diagnosis and therapy
Q35953372CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Q37224921CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma
Q45870963CD28 and 41BB Costimulation Enhances the Effector Function of CD19-Specific Engager T Cells
Q36279306CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
Q39081204CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy
Q27022957CD4 T-cell immunotherapy for chronic viral infections and cancer
Q36951719CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo
Q35655089CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis
Q42586718CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany
Q45783720CLL/SLL diagnosed in an adolescent
Q37666309CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
Q93133450CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
Q39027714Can we make a better match or mismatch with KIR genotyping?
Q58080400Cancer Diagnosis and Immunotherapy in the age of CRISPR
Q64987872Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities.
Q38283536Cancer Immunotherapy Using γδT Cells: Dealing with Diversity
Q56889030Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma
Q38616707Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models
Q38737924Cancer Immunotherapy: Whence and Whither
Q59133785Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes
Q91740150Cancer biomarkers for targeted therapy
Q37655422Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration.
Q38106230Cancer immunotherapies, their safety and toxicity.
Q27026870Cancer immunotherapy
Q29619918Cancer immunotherapy comes of age
Q34309399Cancer immunotherapy in clinical practice -- the past, present, and future.
Q36387028Cancer immunotherapy: Strategies for personalization and combinatorial approaches
Q38151738Cancer immunotherapy: accomplishments to date and future promise
Q39297560Cancer immunotherapy: are we there yet?
Q36637039Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
Q97546137Cancer systems immunology
Q26782604Cancer-treatment-induced neurotoxicity--focus on newer treatments
Q52592605Cardiotoxicity of Immunotherapy: Incidence, Diagnosis, and Management.
Q37095348Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Q36757071Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor
Q91933415Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors
Q92970937Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
Q47738496Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy.
Q38794293Cell and gene therapy strategies to eradicate HIV reservoirs
Q55887721Cell therapy fights leukaemia
Q38777005Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir
Q36984482Cell-based immunotherapy against gliomas: from bench to bedside
Q90288095Cell-based immunotherapy approaches for multiple myeloma
Q38219579Cell-based strategies to manage leukemia relapse: efficacy and feasibility of immunotherapy approaches
Q42613853Cell-based therapeutics: the next pillar of medicine
Q36261159Cellular and Antibody Based Approaches for Pediatric Cancer Immunotherapy
Q36801106Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes
Q27014912Cellular immunotherapy for pediatric solid tumors
Q38104288Cellular immunotherapy for plasma cell myeloma.
Q38217594Cellular immunotherapy strategies for Ewing sarcoma
Q47764871Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia
Q36552098Cellular therapies in acute lymphoblastic leukemia
Q52569021Cellular therapies: Day by day, all the way.
Q45875669Cellular therapy for cancer: let there be light
Q35843507Challenges and future perspectives of T cell immunotherapy in cancer
Q34343785Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group
Q36257036Challenges and opportunities of allogeneic donor-derived CAR T cells
Q36372755Characterization of T-cell receptors directed against HLA-A*01-restricted and C*07-restricted epitopes of MAGE-A3 and MAGE-A12.
Q55322285Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model.
Q89486119Characterization of an Anti-CD5 Directed CAR T-Cell against T-Cell Malignancies
Q57482923Characterization of clinical grade CD19 chimeric antigen receptor T cells produced using automated CliniMACS Prodigy system
Q37308164Characterization of distinct immunophenotypes across pediatric brain tumor types
Q48562384Chasing cancer with chimeric antigen receptor therapy.
Q57300937Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
Q38837680Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma
Q58768316Chemokine Receptors and Exercise to Tackle the Inadequacy of T Cell Homing to the Tumor Site
Q33792344Chemokines as Cancer Vaccine Adjuvants.
Q34041792Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
Q33783145Children's Oncology Group's 2013 blueprint for research: stem cell transplantation.
Q37609801Chimaeric antigen receptor T-cell therapy for tumour immunotherapy
Q53705286Chimeric Antigen Receptor Expressing Natural Killer Cells for the Immunotherapy of Cancer.
Q52663662Chimeric Antigen Receptor T Cell Therapy and the Kidney: What the Nephrologist Needs to Know.
Q36722700Chimeric Antigen Receptor T Cell Therapy in Hematology
Q37347313Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4+ T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppres
Q36284584Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma
Q38957129Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse
Q39082264Chimeric Antigen Receptor T Cells in Hematologic Malignancies
Q47332598Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
Q64957593Chimeric Antigen Receptor T Cells: A Race to Revolutionize Cancer Therapy.
Q38913549Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You.
Q36884399Chimeric Antigen Receptor T-Cell Therapy for the Community Oncologist
Q50531950Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.
Q59137010Chimeric Antigen Receptor T-Cells: Successful Translation of the First Cell and Gene Therapy From Bench to Bedside
Q89419402Chimeric Antigen Receptor Therapy
Q39401736Chimeric Antigen Receptor Therapy in Acute Lymphoblastic Leukemia Clinical Practice
Q26799357Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street
Q46058008Chimeric Antigen Receptor-Modified T Cells Redirected to EphA2 for the Immunotherapy of Non-Small Cell Lung Cancer
Q92301970Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies
Q89895682Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data
Q58575867Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE
Q26773309Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy
Q38795058Chimeric Antigen Receptors for Cancer Immunotherapy
Q36720681Chimeric NKG2D CAR-expressing T cell-mediated attack of human ovarian cancer is enhanced by histone deacetylase inhibition
Q59793960Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance
Q64054386Chimeric antigen receptor (CAR) T-cell therapy as a treatment option for patients with B-cell lymphomas: perspectives on the therapeutic potential of Axicabtagene ciloleucel
Q42246628Chimeric antigen receptor (CAR)-directed adoptive immunotherapy: a new era in targeted cancer therapy
Q36682313Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein.
Q38685785Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV.
Q27312288Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials
Q37436837Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
Q49280922Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward.
Q52588132Chimeric antigen receptor T cell therapy for non-Hodgkin lymphoma.
Q38732332Chimeric antigen receptor T cell treatment in hematologic malignancies
Q85800899Chimeric antigen receptor T cells for ALL
Q29617588Chimeric antigen receptor T cells for sustained remissions in leukemia
Q41429394Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
Q38600697Chimeric antigen receptor T-cell therapies for lymphoma
Q47776210Chimeric antigen receptor T-cell therapies for multiple myeloma
Q47681829Chimeric antigen receptor T-cell therapy - assessment and management of toxicities.
Q64270990Chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma: opportunities and challenges
Q39442191Chimeric antigen receptor T-cells for B-cell malignancies
Q36858767Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma
Q39208504Chimeric antigen receptor engineered stem cells: a novel HIV therapy
Q38435415Chimeric antigen receptor engineering: a right step in the evolution of adoptive cellular immunotherapy
Q34256494Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects
Q38171402Chimeric antigen receptor modified T cell therapy for B cell malignancies
Q27013599Chimeric antigen receptor therapy for cancer
Q38096540Chimeric antigen receptor therapy for chronic lymphocytic leukemia: what are the challenges?
Q36845643Chimeric antigen receptor--modified T cells: clinical translation in stem cell transplantation and beyond
Q27025300Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
Q38873430Chimeric antigen receptor-engineered T cells for liver cancers, progress and obstacles
Q35980893Chimeric antigen receptor-engineered T cells for the treatment of metastatic prostate cancer
Q34046190Chimeric antigen receptor-engineered T cells in CLL: the next chapter unfolds
Q59329883Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
Q34044910Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo
Q29620130Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
Q50042810Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer.
Q38845812Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps
Q37040370Chimeric antigen receptor-modified T cells strike back
Q34765959Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity
Q43575698Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor
Q34248531Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
Q36386891Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies
Q38987239Chimeric antigen receptors for treatment of glioblastoma: a practical review of challenges and ways to overcome them
Q50984719Chimeric antigen receptors: a costimulatory boost promotes immunological memory to B-cell malignancies.
Q47812178Chimeric switch receptor: switching for improved adoptive T-cell therapy against cancers
Q45832774Chimeric-antigen receptor T (CAR-T) cell therapy for solid tumors: challenges and opportunities
Q90330460Chronic Lymphocytic Leukaemia in 2020: the Future Has Arrived
Q87869046Chronic lymphocytic leukaemia
Q94562886Chronic lymphocytic leukemia in 2020: a surfeit of riches?
Q38646074Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment
Q26752467Chronic lymphocytic leukemia: a clinical review including Korean cohorts
Q36609259Chronic lymphocytic leukemia: inception to cure: are we there?
Q35149637Classification of current anticancer immunotherapies
Q38962267Clinical Practice Recommendations for Use of Allogeneic Hematopoietic Cell Transplantation in Chronic Lymphocytic Leukemia on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation
Q34511646Clinical application of genetically modified T cells in cancer therapy
Q100395396Clinical development of CAR T cell therapy in China: 2020 update
Q33823270Clinical development of anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Q26743393Clinical development of gene therapy: results and lessons from recent successes
Q38668561Clinical development of immunotherapy for prostate cancer
Q26747037Clinical manufacturing of CAR T cells: foundation of a promising therapy
Q52774309Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations.
Q38195338Clinical potential of gene therapy: towards meeting the demand
Q37042225Clinical responses with T lymphocytes targeting malignancy-associated κ light chains
Q38105123Clinical significance of minimal residual disease in patients with acute leukaemia undergoing haematopoietic stem cell transplantation
Q36762882Clinical targeting of the TNF and TNFR superfamilies
Q61797408Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia
Q38094811Clinical trials in cellular immunotherapy for brain/CNS tumors
Q42654456Clinical trials of CAR-T cells in China
Q50041712Clinical trials of CD19-targeted CAR-modified T cell therapy; a complex and varied landscape.
Q64005145Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia
Q38195120Clinical utility of natural killer cells in cancer therapy and transplantation
Q39177978Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy.
Q42280014Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients.
Q88763304Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma
Q52655396Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells.
Q33749635Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
Q38811497Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity.
Q34487698Combination cancer immunotherapy and new immunomodulatory targets
Q36018407Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells
Q34552128Combination immunotherapy: a road map.
Q39111239Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma.
Q91947120Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma
Q40427938Combining Cell and Gene Therapy in an Effort to Eradicate HIV.
Q37443603Combining T-cell immunotherapy and anti-androgen therapy for prostate cancer
Q28537688Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma
Q38447992Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?
Q35196739Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals
Q47570358Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
Q39408105Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.
Q34808631Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer
Q36377047Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens
Q37127489Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells
Q35563824Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.
Q37129564Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG.
Q40183378Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells
Q50914423Conference scene: Immune signatures in the tumor and beyond.
Q45870279Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy
Q36963057Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells
Q41437137Construction of stable packaging cell lines for clinical lentiviral vector production
Q35149457Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen.
Q89793732Controlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy
Q36349583Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Q38064950Convergence of gene and cell therapy
Q47821811Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity.
Q50936078Cord blood T cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity.
Q55262180Crisis or self-correction: Rethinking media narratives about the well-being of science.
Q38085989Curing HIV: lessons from cancer therapy
Q38830071Current Progress in Immunotherapy for the Treatment of Biliary Cancers
Q92662855Current Status and Future Perspectives of Immunotherapy for Locally Advanced or Metastatic Urothelial Carcinoma: A Comprehensive Review
Q49829282Current Status of Gene Engineering Cell Therapeutics.
Q35215158Current advances in T-cell-based cancer immunotherapy
Q26745411Current clinical immunotherapeutic approaches for head and neck cancer
Q33886879Current concepts in the diagnosis and management of cytokine release syndrome
Q39189908Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines
Q26799720Current practices and reform proposals for the regulation of advanced medicinal products in Canada
Q39280002Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment
Q49504358Current status and progress of lymphoma management in China.
Q39301512Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies
Q38631108Current status of chimeric antigen receptor therapy for haematological malignancies
Q55715408Current status of immunotherapy against gastrointestinal cancers and its biomarkers: Perspective for precision immunotherapy.
Q38068967Current strategies in immunotherapy for acute myeloid leukemia
Q50027576Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells.
Q38164108Current therapy and novel agents for relapsed or refractory acute lymphoblastic leukemia
Q27024456Current translational and clinical practices in hematopoietic cell and gene therapy
Q36397924Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US i
Q95648221Cytokine IL-36γ improves CAR T-cell functionality and induces endogenous antitumor response
Q39385892Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.
Q40247636Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy.
Q55438228Cytokine release syndrome.
Q58700983Cytokine release syndrome: grading, modeling, and new therapy
Q89613154Cytotoxic CD8+ Lymphocytes in the Tumor Microenvironment
Q36694195Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ.
Q37991701Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects
Q37222769DNA aptamer-mediated cell targeting
Q38948889DNA-based immunotherapy for HPV-associated head and neck cancer
Q35209066DNAM-1-based chimeric antigen receptors enhance T cell effector function and exhibit in vivo efficacy against melanoma
Q92354573Decitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma
Q88573546Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis
Q39320917Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial.
Q37420778Dendritic cell-based immunotherapy for myeloid leukemias.
Q47547004Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression.
Q89633817Design and Characterization of an "All-in-One" Lentiviral Vector System Combining Constitutive Anti-GD2 CAR Expression and Inducible Cytokines
Q51851755Design and Potential of Non-Integrating Lentiviral Vectors.
Q37418289Design and development of therapies using chimeric antigen receptor-expressing T cells
Q38170500Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells
Q34439729Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses
Q38805082Design of chimeric antigen receptors with integrated controllable transient functions.
Q41964506Designing CAR T cells for glioblastoma
Q88955690Designing cell function: assembly of synthetic gene circuits for cell biology applications
Q38260051Designing effective vaccines for colorectal cancer.
Q36100435Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia
Q38003108Detection of EPO gene doping in blood
Q26996310Developing strategies in the immunotherapy of leukemias
Q28730144Development and utility of an internal threshold control (ITC) real-time PCR assay for exogenous DNA detection
Q28067476Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy
Q39200527Development of CAR T cells designed to improve antitumor efficacy and safety
Q58614180Development of Inducible CD19-CAR T Cells with a Tet-On System for Controlled Activity and Enhanced Clinical Safety
Q52365121Development of Molecularly Targeted Agents and Immunotherapies in Glioblastoma: A Personalized Approach.
Q50035377Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma.
Q41820949Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
Q38999828Development of an equine-tropic replication-competent lentivirus assay for equine infectious anemia virus-based lentiviral vectors
Q37132611Development of gene therapy for blood disorders: an update
Q50885033Development of immuno-oncology drugs - from CTLA4 to PD1 to the next generations.
Q39391468Development of novel antigen receptors for CAR T-cell therapy directed toward solid malignancies
Q36820360Diacylglycerol kinases: regulated controllers of T cell activation, function, and development
Q88947859Diagnosis and management of pulmonary toxicity associated with cancer immunotherapy
Q38860645Dielectrophoresis-assisted 3D nanoelectroporation for non-viral cell transfection in adoptive immunotherapy.
Q34297618Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies
Q54839684Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques.
Q90134023Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy
Q38906557Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma.
Q58889356Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Q36819337Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies
Q37390239Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
Q44064028Double or nothing on cancer immunotherapy
Q34046505Driving CAR T-cells forward
Q37715684Driving CAR-based T-cell therapy to success
Q41844141Driving an improved CAR for cancer immunotherapy
Q38777742Driving gene-engineered T cell immunotherapy of cancer
Q93048204Durable Molecular Remission in a Lymphoid BP-CML Patient Harboring T315I Mutation Treated with Anti-CD19 CAR-T Therapy
Q37618652EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
Q35145144EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma
Q50681689Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies.
Q38747333Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo
Q39324107Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma.
Q47187516Efficacy From Strange Sources
Q38035043Efficacy and safety of adoptive immunotherapy using anti-CD19 chimeric antigen receptor transduced T-cells: a systematic review of phase I clinical trials
Q47183140Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis.
Q29617590Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
Q36545348Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis
Q38723282Efficient Transduction of Human and Rhesus Macaque Primary T Cells by a Modified Human Immunodeficiency Virus Type 1-Based Lentiviral Vector
Q35847460Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States
Q33587034Elimination of progressive mammary cancer by repeated administrations of chimeric antigen receptor-modified T cells
Q30252944Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells.
Q90479721Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review
Q52596335Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Q88549071Emerging Systemic Therapies for Colorectal Cancer
Q91776744Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia
Q38172586Emerging drugs for acute lymphocytic leukemia
Q38543771Emerging immunological drugs for chronic lymphocytic leukemia
Q37025105Emerging immunotherapies for glioblastoma
Q38075407Emerging immunotherapies in older adults with acute myeloid leukemia
Q38806960Emerging role of immunotherapy in urothelial carcinoma-Future directions and novel therapies
Q38207143Emerging therapies for refractory chronic lymphocytic leukemia
Q91994349Emerging treatment options for patients with p53-pathway-deficient CLL
Q38235439Emerging trends and new developments in regenerative medicine: a scientometric update (2000 - 2014).
Q56891263Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers
Q35591391Engager T cells: a new class of antigen-specific T cells that redirect bystander T cells
Q37711887Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
Q38623827Engineered T cell therapies
Q36755385Engineered T cells for anti-cancer therapy.
Q34080368Engineered T cells for cancer therapy.
Q33578792Engineered T cells for cancer treatment
Q55086081Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.
Q38828829Engineered T cells: the promise and challenges of cancer immunotherapy.
Q52641577Engineered T lymphocytes eliminate lung metastases in models of pancreatic cancer.
Q85092790Engineered T-cell therapy shows efficacy in blood cancer
Q36936632Engineered human embryonic stem cell-derived lymphocytes to study in vivo trafficking and immunotherapy
Q58694793Engineering CAR-T Cells for Improved Function Against Solid Tumors
Q39399864Engineering CAR-T cells
Q38290031Engineering CAR-T cells: Design concepts
Q92488848Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy
Q40351372Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells
Q38742968Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
Q92150152Engineering advanced cancer therapies with synthetic biology
Q91847813Engineering for Success: Approaches to Improve Chimeric Antigen Receptor T Cell Therapy for Solid Tumors
Q90317680Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation
Q92513208Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset
Q91614877Engineering switchable and programmable universal CARs for CAR T therapy
Q38231581Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: review and future prospects
Q102210885Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
Q90106278Enhanced activation and expansion of T cells using mechanically soft elastomer fibers
Q34338159Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis
Q36941051Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases
Q36882726Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA.
Q50025585Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Q92306387Enhancing CAR T-cell therapy through cellular imaging and radiotherapy
Q35399334Enhancing antitumor efficacy of chimeric antigen receptor T cells through constitutive CD40L expression.
Q50426810Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells.
Q89030540Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Q38525024Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression
Q34172063Entering the era of targeted therapy for chronic lymphocytic leukemia: impact on the practicing clinician.
Q35252186Eradicating HIV-1 infection: seeking to clear a persistent pathogen
Q38389298ErbB-targeted CAR T-cell immunotherapy of cancer
Q92337122Escape From ALL-CARTaz: Leukemia Immunoediting in the Age of Chimeric Antigen Receptors
Q38769264Establishing guidelines for CAR-T cells: challenges and considerations
Q36698269Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
Q92236859Evaluating tisagenlecleucel and its potential in the treatment of relapsed or refractory diffuse large B cell lymphoma: evidence to date
Q36675286Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases
Q27006179Evaluation of current cancer immunotherapy: hemato-oncology
Q54108755Evolution of CLL treatment - from chemoimmunotherapy to targeted and individualized therapy.
Q59329233Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium
Q45288675Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells
Q37081838Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging
Q94559906Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells
Q41490849Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement
Q36715205Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy
Q53369837Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities.
Q28075992Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic
Q37576033Exploiting the curative potential of adoptive T-cell therapy for cancer
Q93110692Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma
Q39400633Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor
Q49710595Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers.
Q39062014Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.
Q38365989Expression of chimeric receptor CD4ζ by natural killer cells derived from human pluripotent stem cells improves in vitro activity but does not enhance suppression of HIV infection in vivo.
Q91529500Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas
Q33606096Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts
Q36259431Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Q99614559Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B cell malignancies
Q42552682False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector
Q54233028False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy.
Q36465536Faster, cheaper, safer, T-cell engineering
Q47218376Favorable immune signature in CLL patients, defined by antigen-specific T-cell responses, might prevent second skin cancers
Q38758789Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma.
Q92702413Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies
Q46112550Fine-tuning Tumor Immunity with Integrin Trans-regulation
Q40667941Flow-Through Electroporation of HL-60 White Blood Cell Suspensions using Nanoporous Membrane Electrodes
Q88778743Fludarabine and neurotoxicity in engineered T-cell therapy
Q38889816Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging
Q47726467Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy.
Q35764479Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.
Q50635113Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.
Q38468283From humble beginnings to success in the clinic: Chimeric antigen receptor-modified T-cells and implications for immunotherapy.
Q34240799From the mouse cage to human therapy: a personal perspective of the emergence of T-bodies/chimeric antigen receptor T cells
Q38951943From therapeutic antibodies to chimeric antigen receptors (CARs): making better CARs based on antigen-binding domain.
Q92715263Frontline therapies for untreated chronic lymphoid leukemia
Q64230023Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines
Q36281920Fully human CD19-specific chimeric antigen receptors for T-cell therapy
Q50027691Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains.
Q60923010Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor
Q37692713Functional NK cell repertoires are maintained through IL-2Rα and Fas ligand.
Q36220235Functional disruption of human leukocyte antigen II in human embryonic stem cell
Q36862410Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy
Q38434000Future of Therapy in Acute Lymphoblastic Leukemia (ALL)--Potential Role of Immune-Based Therapies
Q30244168Future prospects of therapeutic clinical trials in acute myeloid leukemia
Q90482982GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas
Q38782845GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade
Q36842259GIFT4 fusokine converts leukemic B cells into immune helper cells
Q93336074GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
Q55353959GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR.
Q41625041GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
Q37950928GUCY2C-targeted cancer immunotherapy: past, present and future.
Q52721830Gene Therapy With Regulatory T Cells: A Beneficial Alliance.
Q35541787Gene and cell therapy for pancreatic cancer
Q67201058Gene editing for immune cell therapies
Q37185223Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy
Q64041023Gene therapies advance towards finish line
Q45880394Gene therapy matures in the clinic
Q27007012Gene therapy on the move
Q38654544Gene therapy research in Asia
Q36740288Gene therapy researchers' assessments of risks and perceptions of risk acceptability in clinical trials
Q33782832Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.
Q92355483Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies
Q38123667Gene-engineered T cells for cancer therapy
Q101476557Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR T cell testing
Q91954015Generation of Antitumor T Cells For Adoptive Cell Therapy With Artificial Antigen Presenting Cells
Q35162266Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care.
Q35651760Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
Q38426341Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors
Q34531834Generation of functional CLL-specific cord blood CTL using CD40-ligated CLL APC.
Q47438128Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro
Q34487189Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.
Q52431278Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy.
Q37965815Genetic engineering of T cells for the immunotherapy of haematological malignancies.
Q37481319Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors.
Q33992425Genetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells
Q36366557Genetic modification of human T lymphocytes for the treatment of hematologic malignancies
Q34270304Genetically InFormed therapies--a "GIFT" for children with cancer
Q37587362Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies.
Q90862859Genetically engineered T cells for cancer immunotherapy
Q34645898Genetically engineered T cells for the treatment of cancer
Q55380614Genetically enhanced T lymphocytes and the intensive care unit.
Q26860657Genetically modified T cells for the treatment of malignant disease
Q27026627Genetically modified T cells in cancer therapy: opportunities and challenges
Q37164976Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery
Q38178690Genetically modified T cells to target glioblastoma
Q36198232Genetically modified T-cell therapy for osteosarcoma
Q33729598Genome-Edited T Cell Therapies.
Q28087672Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
Q44404784Genomics and drug discovery
Q55358019Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity.
Q37717884Global Manufacturing of CAR T Cell Therapy
Q38289029Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies
Q52729230Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel.
Q91905271Granulocyte-macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators
Q39120155Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer
Q52691583Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.
Q92472960HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA+ liver metastases
Q88312666HLA ligandome analysis of primary chronic lymphocytic leukemia (CLL) cells under lenalidomide treatment confirms the suitability of lenalidomide for combination with T-cell-based immunotherapy
Q34204696HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice
Q35880618Haematological malignancies: at the forefront of immunotherapeutic innovation
Q35645932Harnessing autophagy for adoptive T-cell therapy
Q37043025Harnessing autophagy for cell fate control gene therapy
Q27021570Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy
Q92156519Harnessing the Effects of BTKi on T Cells for Effective Immunotherapy against CLL
Q28088598Harnessing the Microbiome to Enhance Cancer Immunotherapy
Q36416452Hematopoietic stem cell transplantation for chronic lymphocytic leukemia
Q34463419Hematopoietic stem cell transplantation-50 years of evolution and future perspectives
Q37512048Hematopoietic stem cells for cancer immunotherapy
Q39398719Hemophilia A inhibitor treatment: the promise of engineered T-cell therapy
Q52775663Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Q50032893High efficacy and safety of low-dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients.
Q64956892High-Throughput Microfluidic 3D Cytotoxicity Assay for Cancer Immunotherapy (CACI-IMPACT Platform).
Q28066792High-content molecular profiling of T-cell therapy in oncology
Q94024228Highlights from the Literature
Q46507832Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting
Q91344495Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors
Q38830813How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy
Q54348577How I treat patients with relapsed chronic lymphocytic leukaemia.
Q88645380How and when I do allogeneic transplant in CLL
Q36476104How do CARs work?: Early insights from recent clinical studies targeting CD19.
Q38371637How do i participate in T-cell immunotherapy?
Q92675406How to approach CLL in clinical practice
Q41660817Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells
Q35598804Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Q34391263Human cell-based artificial antigen-presenting cells for cancer immunotherapy
Q98906910Human immunology and immunotherapy: main achievements and challenges
Q37066334Human miR223 promoter as a novel myelo-specific promoter for chronic granulomatous disease gene therapy
Q35939496Human tumor xenografts: the good, the bad, and the ugly
Q38769271Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors
Q64974799Hypoxia Selectively Impairs CAR-T Cells In Vitro.
Q34047847ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
Q35690979IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.
Q36651344Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
Q27026912Ibrutinib: a first in class covalent inhibitor of Bruton's tyrosine kinase
Q35689938Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors
Q33738328Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
Q36470331Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers
Q35328354Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells
Q42287234Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOβ as a novel target for multiple myeloma
Q27334215Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing
Q91693969Imaging CAR T cell therapy with PSMA-targeted positron emission tomography
Q53191013Imaging of T cells expressing chimeric antigen receptors.
Q26796307Immune Modulation in Hematologic Malignancies
Q38108353Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity
Q38806038Immune checkpoint inhibitors in gynecologic cancers with lessons learned from non-gynecologic cancers
Q33691970Immune escape from NY-ESO-1-specific T-cell therapy via loss of heterozygosity in the MHC.
Q38111096Immune modulation by genetic modification of dendritic cells with lentiviral vectors.
Q26865561Immune reconstitution in chronic lymphocytic leukemia
Q39057617Immune targets and neoantigens for cancer immunotherapy and precision medicine
Q38263108Immune-based therapies for childhood cancer.
Q45933560Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity.
Q26765115Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
Q37047061Immunoediting and antigen loss: overcoming the achilles heel of immunotherapy with antigen non-specific therapies
Q37535106Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells
Q37417622Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research
Q43884851Immunology. Making macrophages eat cancer
Q52346985Immunomodulation in hepatocellular cancer.
Q40829702Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.
Q36778827Immunotherapeutic approaches in triple-negative breast cancer: latest research and clinical prospects
Q38171067Immunotherapeutic approaches to treat multiple myeloma
Q38890717Immunotherapeutic strategies targeting natural killer T cell responses in cancer.
Q91904998Immunotherapies for pediatric cancer: current landscape and future perspectives
Q55362851Immunotherapies: Exploiting the Immune System for Cancer Treatment.
Q49995864Immunotherapy Strategies Against Multiple Myeloma.
Q90609334Immunotherapy and Radiation - A New Combined Treatment Approach for Bladder Cancer?
Q38610306Immunotherapy and tumor microenvironment
Q39016790Immunotherapy approaches in the treatment of malignant brain tumors
Q42427577Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation.
Q52587066Immunotherapy for Breast Cancer: Current and Future Strategies.
Q38580545Immunotherapy for Multiple Myeloma, Past, Present, and Future: Monoclonal Antibodies, Vaccines, and Cellular Therapies
Q38155343Immunotherapy for chronic lymphocytic leukemia in the era of BTK inhibitors
Q26745428Immunotherapy for head and neck cancer: latest developments and clinical potential
Q35567765Immunotherapy for hepatocellular carcinoma: From basic research to clinical use.
Q38722325Immunotherapy for pancreatic cancer
Q36968163Immunotherapy for pediatric leukemia
Q38959645Immunotherapy for prostate cancer: False promises or true hope?
Q33709232Immunotherapy for solid tumors--a review for surgeons
Q38533606Immunotherapy in acute myeloid leukemia
Q33593865Immunotherapy in hematologic malignancies: past, present, and future
Q36691818Immunotherapy in pediatric malignancies: current status and future perspectives
Q40099075Immunotherapy of cancers comes of age.
Q39253341Immunotherapy of hepatocellular carcinoma using chimeric antigen receptors and bispecific antibodies
Q36470354Immunotherapy of malignant disease using chimeric antigen receptor engrafted T cells
Q56897379Immunotherapy of melanoma
Q41259289Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells
Q27021939Immunotherapy strategies for multiple myeloma: the present and the future
Q35971029Immunotherapy targets in pediatric cancer
Q55216327Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies.
Q38117268Immunotherapy with gene-modified T cells: limiting side effects provides new challenges.
Q37690444Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor.
Q50049352Immunotherapy: Treatment of aggressive lymphomas with anti-CD19 CAR T cells.
Q58326921Immunothérapie des cancers : une lueur au bout du tunnel ?
Q42265908Impact of T cell selection methods in the success of clinical adoptive immunotherapy
Q38398877Impact of the immune system and immunotherapy in colorectal cancer
Q42281477Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis.
Q52568132Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium.
Q41879726Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice
Q40933832Improved disease markers suggest dual response in a patient with metastatic castration resistant prostate cancer and chronic lymphocytic leukemia following active cellular immunotherapy
Q28068378Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination
Q59349994Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager
Q38719148Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
Q50051034Improving immune-vascular crosstalk for cancer immunotherapy.
Q36238795Improving the outcome for children with cancer: Development of targeted new agents
Q41914105Improving the outcome of adoptive cell transfer by targeting tumor escape
Q38912826Improving the safety of T-Cell therapies using an inducible caspase-9 gene
Q34453846Improving the safety of cell therapy products by suicide gene transfer
Q34477411Improving the safety of cell therapy with the TK-suicide gene
Q36777093Improving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cells
Q53791668In Vitro Generation of Antigen-Specific T Cells from Induced Pluripotent Stem Cells of Antigen-Specific T Cell Origin.
Q57493527In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas
Q39087734In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection
Q21559398In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells
Q52780147In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment.
Q39256918Increasing the safety and efficacy of chimeric antigen receptor T cell therapy
Q36572920Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Q34980976Induction of high-titer IgG antibodies against multiple leukemia-associated antigens in CML patients with clinical responses to K562/GVAX immunotherapy.
Q50026906Infectious complications of CD19-targeted chimeric antigen receptor-modified T-cell immunotherapy.
Q37554202Inferring the Impact of Regulatory Mechanisms that Underpin CD8+ T Cell Control of B16 Tumor Growth In vivo Using Mechanistic Models and Simulation
Q27023490Inflammation, obesity, and the promise of immunotherapy for metabolic disease
Q42704100Informed Consent: A Clinical Trials Perspective.
Q35988657Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies.
Q35053924Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Q36300179Innovative regenerative medicines in the EU: a better future in evidence?
Q64053139Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma
Q39187306Insights into molecular therapy of glioma: current challenges and next generation blueprint
Q26830304Integrating biological redesign: where synthetic biology came from and where it needs to go
Q104136735Integration of mechanistic immunological knowledge into a machine learning pipeline improves predictions
Q26861559Interleukin 12: still a promising candidate for tumor immunotherapy?
Q34177641Interleukin-13 receptor alpha 2-targeted glioblastoma immunotherapy.
Q64275741Interleukin-18 in Health and Disease
Q89519257Interleukin-23 engineering improves CAR T cell function in solid tumors
Q38753216Interleukin-33 in tumorigenesis, tumor immune evasion, and cancer immunotherapy
Q39005211Intraperitoneal immunotherapy: historical perspectives and modern therapy
Q38424720Intratympanic Gene Delivery of Antimicrobial Molecules in Otitis Media
Q47911139Introduction to Cancer Stem Cells: Past, Present, and Future
Q34431441Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
Q87954935In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia
Q37564361Is cancer gene therapy an empty suit?
Q38098877Is hematopoietic cell transplantation still a valid option for mantle cell lymphoma in first remission in the chemoimmunotherapy-era?
Q42373110Is virology dead?
Q37100031Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy
Q91971816Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer
Q57961814Killers on sterols
Q64093637Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
Q47682409Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.
Q39064900Kinetics of tumor destruction by chimeric antigen receptor-modified T cells
Q37500940Koch Institute Symposium on Cancer Immunology and Immunotherapy
Q37632809Landscape of tumor-infiltrating T cell repertoire of human cancers
Q34372167Large-scale expansion of γδ T cells and peptide-specific cytotoxic T cells using zoledronate for adoptive immunotherapy
Q46319985Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor-Redirected T Cells Against Multiple Myeloma.
Q92863318Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity
Q38147100Lentiviral vectors for cancer immunotherapy and clinical applications
Q38389312Lentiviral vectors in cancer immunotherapy
Q53891545Lentivirus-Induced Dendritic Cells (iDC) for Immune-Regenerative Therapies in Cancer and Stem Cell Transplantation.
Q36031874Lentivirus-induced 'Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
Q38318616Lentivirus-induced dendritic cells for immunization against high-risk WT1(+) acute myeloid leukemia
Q52372679Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Q89823508Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment
Q40095482Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy
Q34508322Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)
Q30828860Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors.
Q26782902Lymphoma Immunotherapy: Current Status
Q50034163Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.
Q39245218Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy.
Q100518777L’immunologie : les bases pour comprendre les traitements actuels et à venir: Immunology: The basis for understanding current and future treatments
Q26771192MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy
Q92586096Making cold malignant pleural effusions hot: driving novel immunotherapies
Q56929047Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy
Q33993517Managing cytokine release syndrome associated with novel T cell-engaging therapies.
Q34769213Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents?
Q36796025Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies
Q34760414Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells
Q42198836Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.
Q36194241Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias
Q84937064Markov model of CLL transplants
Q26749560Marrow-Infiltrating Lymphocytes - Role in Biology and Cancer Therapy
Q37208363Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients
Q38730881Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice.
Q90218846Mechanisms of Leukemia Immune Evasion and Their Role in Relapse After Haploidentical Hematopoietic Cell Transplantation
Q39169789Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia
Q92150199Mechanisms of resistance to CAR T cell therapy
Q28083766Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy
Q41208517Medical management of side effects related to CAR T cell therapy in hematologic malignancies
Q38802594Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells
Q26798404Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy
Q38773361Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy
Q37134884Mesothelin, a novel immunotherapy target for triple negative breast cancer
Q37599478Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.
Q39418546Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Q55089089Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells.
Q47718243Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells.
Q38658670Methods of ex vivo expansion of human cord blood cells: challenges, successes and clinical implications
Q47127214Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity
Q39214379Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo
Q28067102Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments
Q38180319Mitigating the toxic effects of anticancer immunotherapy
Q36562453Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.
Q64907480Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia.
Q40675376Modification of Expanded NK Cells with Chimeric Antigen Receptor mRNA for Adoptive Cellular Therapy
Q38834059Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies
Q39104849Modification of hematopoietic stem/progenitor cells with CD19-specific chimeric antigen receptors as a novel approach for cancer immunotherapy.
Q34167797Modular extracellular sensor architecture for engineering mammalian cell-based devices
Q50925934Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.
Q36928580Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy
Q42082214Molecular characterization of a fully human chimeric T-cell antigen receptor for tumor-associated antigen EpCAM.
Q35666734Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B.
Q38117139Molecular insights for optimizing T cell receptor specificity against cancer
Q88885438Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Q37677563Mouse models in bone marrow transplantation and adoptive cellular therapy
Q38218786Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses.
Q64102615Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies
Q34052580Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
Q34334598Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy
Q47555946Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature
Q34139613Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.
Q36177909Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
Q34047618Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
Q38895203Multiplexed gene transfer to a human T-cell line by combining Sleeping Beauty transposon system with methotrexate selection
Q36452648Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody
Q91930473My journey from tyrosine phosphorylation inhibitors to targeted immune therapy as strategies to combat cancer
Q36982805Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells
Q50027824NK-92 cell, another ideal carrier for chimeric antigen receptor.
Q38631020NK-92: an 'off-the-shelf therapeutic' for adoptive natural killer cell-based cancer immunotherapy
Q36980241NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors
Q33595873NKG2D CARs as cell therapy for cancer
Q27014888NKG2D ligands as therapeutic targets
Q38656067NLRC5/CITA: A Key Player in Cancer Immune Surveillance.
Q92766318Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice
Q38690435Nanoscale bio-platforms for living cell interrogation: current status and future perspectives
Q95642943Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer
Q42562347Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies.
Q38054112Nanovectorized radiotherapy: a new strategy to induce anti-tumor immunity
Q61818149Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor Immunotherapy
Q26745906Natural Killer Cells for Therapy of Leukemia
Q26830512Natural killer cell biology: an update and future directions
Q35556865Natural killer cell engineering for cellular therapy of cancer
Q41613624Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma
Q57172529Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future
Q47761448New Approaches in CAR-T Cell Immunotherapy for Breast Cancer.
Q37344050New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation
Q33922797New aspects of neuroblastoma treatment: ASPHO 2011 symposium review
Q93120938New biomarkers and therapeutic strategies in acute lymphoblastic leukemias: Recent advances
Q38406089New cell sources for T cell engineering and adoptive immunotherapy
Q35996395New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
Q38428357New insights into the pathophysiology and therapy of adult acute lymphoblastic leukemia
Q26828496New strategies in chronic lymphocytic leukemia: shifting treatment paradigms
Q38130615New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.
Q51839566New targeted therapies for relapsed pediatric acute lymphoblastic leukemia.
Q92723315Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity
Q35745453Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity
Q33874986Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation
Q38664735Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?
Q64097181Novel biomanufacturing platform for large-scale and high-quality human T cells production
Q36185518Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
Q38066860Novel cellular therapies for leukemia: CAR-modified T cells targeted to the CD19 antigen
Q26770391Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic)
Q27004436Novel immunotherapies for hematologic malignancies
Q26777394Novel immunotherapies in lymphoid malignancies
Q38248461Novel methods and approaches to acute lymphoblastic leukemia drug discovery
Q34347703Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses.
Q38120551Novel targeted therapies in acute lymphoblastic leukemia
Q28069889Novel therapeutic options in Acute Myeloid Leukemia
Q38924557Novel therapeutic strategies in human malignancy: combining immunotherapy and oncolytic virotherapy
Q39368957Novel therapy for childhood acute lymphoblastic leukemia
Q38925720Obesity and cancer immunotherapy toxicity
Q100430603Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice
Q57192334Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
Q38808628Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell
Q52309503Oncolytic viruses as engineering platforms for combination immunotherapy.
Q91907979One-step generation of modular CAR-T cells with AAV-Cpf1
Q34307792Opportunities and limitations of natural killer cells as adoptive therapy for malignant disease
Q36855245Opportunities in immunotherapy of ovarian cancer.
Q40314122Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
Q40792533Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies
Q92983020Optimizing CAR-T Cell Manufacturing Processes during Pivotal Clinical Trials
Q55224144Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma.
Q91964127Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy
Q38840466Optimizing T-cell receptor gene therapy for hematologic malignancies.
Q35184232Optimizing the production of suspension cells using the G-Rex "M" series
Q35783394Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors: an immunological and regulatory challenge
Q34240410Outcomes of human leukocyte antigen-matched sibling donor hematopoietic cell transplantation in chronic lymphocytic leukemia: myeloablative versus reduced-intensity conditioning regimens
Q55515652Overcoming Resistance of Human Non-Hodgkin's Lymphoma to CD19-CAR CTL Therapy by Celecoxib and Histone Deacetylase Inhibitors.
Q64249459Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors
Q50027827Overcoming barriers of car T-cell therapy in patients with mesothelin-expressing cancers.
Q38441750Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
Q38671390Overcoming multiple myeloma drug resistance in the era of cancer 'omics'.
Q38285543Overcoming the toxicity hurdles of genetically targeted T cells
Q38262255Overcoming tumor-mediated immunosuppression
Q37422201Overview of recent developments in chronic lymphocytic leukemia
Q34361637PCR-based detection of gene transfer vectors: application to gene doping surveillance
Q36334073PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines
Q27339832PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models
Q41487925Paired Expression Analysis of Tumor Cell Surface Antigens
Q33940443Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies
Q38259446Paradigm shifts in the management of poor-risk chronic lymphocytic leukemia.
Q89640744Paradox-driven adventures in the development of cancer immunology and immunotherapy
Q26997993Particle-mediated delivery of cytokines for immunotherapy
Q89287784Pediatric Cancer Immunotherapy: Opportunities and Challenges
Q64097880Peptide Super-Agonist Enhances T-Cell Responses to Melanoma
Q90690181Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia
Q38353123Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells
Q37316845Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia
Q37117624Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy
Q89721569Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice
Q35568556Personalized cell transfer immunotherapy for B-cell malignancies and solid cancers
Q37412148Personalized medicine in CLL: current status and future perspectives
Q91869736Perspective: Biophysical regulation of cancerous and normal blood cell lineages in hematopoietic malignancies
Q50875834Perspective: assembly line immunotherapy.
Q38818283Pharmacotherapy of relapsed/refractory chronic lymphocytic leukemia.
Q47589152Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma
Q38787449Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells
Q36761521Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Q35862775Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases
Q92666841Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers
Q45855437Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response
Q37217432Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells
Q36475411Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale
Q46214811Phenotypic models of T cell activation
Q38012709Phoenix rising: gene therapy makes a comeback
Q88965080PiggyBac-Engineered T Cells Expressing CD19-Specific CARs that Lack IgG1 Fc Spacers Have Potent Activity against B-ALL Xenografts
Q96303570Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial
Q36249440Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy
Q47550219Posttransplant chimeric antigen receptor therapy
Q36195192Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus
Q36212699Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells
Q40393182Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy
Q34046041Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
Q38681083Preclinical rationale for combining radiation therapy and immunotherapy beyond checkpoint inhibitors (i.e., CART).
Q37697847Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells
Q41909592Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.
Q42175418Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector.
Q88797021Prevention and treatment of relapse after stem cell transplantation by cellular therapies
Q40402774Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor.
Q27001126Primer on tumor immunology and cancer immunotherapy
Q34598553Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors
Q37609957Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse After Hematopoietic Stem Cell Transplantation: part III. Prevention and treatment of relapse after allogeneic transpl
Q26741260Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors
Q35628678Profile of elotuzumab and its potential in the treatment of multiple myeloma
Q38345576Prognosis and therapy of chronic lymphocytic leukemia and small lymphocytic lymphoma
Q90215603Programming CAR-T cells to kill cancer
Q36713761Progress and challenges in viral vector manufacturing
Q26852923Progress and prospects for engineered T cell therapies
Q38847756Progress of dendritic cell-based cancer vaccines for patients with hematological malignancies
Q38736566Promising immunotherapies for esophageal cancer
Q42581682Promising therapies in multiple myeloma
Q38608986Prospects for adoptive immunotherapy of pancreatic cancer using chimeric antigen receptor-engineered T-cells
Q49401353Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors.
Q34507561Prospects for gene-engineered T cell immunotherapy for solid cancers.
Q41838529Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies
Q57046364Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response
Q90453826Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor
Q39405625Quantitative Imaging Approaches to Study the CAR Immunological Synapse.
Q36683002Quantitative high-throughput single-cell cytotoxicity assay for T cells
Q52676237Quarter Century of Anti-HIV CAR T Cells.
Q55457286Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma?
Q61984736RETRACTED: Steering CAR T Cells into Solid Tumors
Q63740735RNA Viruses as Tools in Gene Therapy and Vaccine Development
Q42724344Radiation and immunotherapy: a synergistic combination.
Q26779221Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications
Q35741739Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma
Q38071110Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity
Q33588711Re-adapting T cells for cancer therapy: from mouse models to clinical trials
Q34520155Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1).
Q90084567Real-time transfer of lentiviral particles by producer cells using an engineered coculture system
Q38045706Reappraising the role of autologous transplantation for indolent B-cell lymphomas in the chemoimmunotherapy era: is it still relevant?
Q34789569Reassessing target antigens for adoptive T-cell therapy
Q38763829Recent advances and future directions in mantle cell lymphoma research: report of the 2016 mantle cell lymphoma consortium workshop
Q28078076Recent advances and novel treatment paradigms in acute lymphocytic leukemia
Q90355383Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management
Q28080312Recent advances in T-cell engineering for use in immunotherapy
Q37244349Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
Q94503527Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
Q35482083Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates
Q36321176Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma
Q58786421Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy
Q41150808Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment
Q50044514Redirected T cells in cancer therapy.
Q28553650Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors
Q45857417Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity
Q46550701Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor
Q50534081Redirection to the bone marrow improves T cell persistence and antitumor functions.
Q38202155Reduced intensity conditioning for allogeneic hematopoietic cell transplantation: considerations for evidence-based GVHD prophylaxis
Q41636566Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas
Q28276800Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Q42559059Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia
Q95841443Regional Injection of CAR-T Cells for the Treatment of Refractory and Recurrent Diffuse Large B Cell Lymphoma: A Case Report
Q39329364Regional immunotherapy for liver and peritoneal metastases
Q64999064Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters.
Q45950927Regulation of T cell proliferation with drug-responsive microRNA switches.
Q38557841Regulatory T cells: tolerance induction in solid organ transplantation
Q27025869Regulatory T-cell therapy in transplantation: moving to the clinic
Q35886454Regulatory considerations for clinical development of cancer vaccines
Q38777377Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy
Q35749986Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?
Q38149916Repositioning therapeutic cancer vaccines in the dawning era of potent immune interventions
Q47201278Reprogramming T-cells for adoptive immunotherapy of ovarian cancer
Q42925805Reprogramming immune responses via microRNA modulation
Q38678579Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer
Q35605398Requirement of Innate Immunity in Tumor-Bearing Mice Cured by Adoptive Immunotherapy Using Tumor-Draining Lymph Nodes
Q35637089Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Q39013616Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance
Q49830211Restoring Natural Killer Cell Immunity against Multiple Myeloma in the Era of New Drugs.
Q36414279Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging
Q37434670Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity
Q38244698Retired self-proteins as vaccine targets for primary immunoprevention of adult-onset cancers
Q41592700Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
Q28074002Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives
Q30580134Reversal of tumor immune inhibition using a chimeric cytokine receptor
Q45873677Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-Cell Malignancies.
Q51743858Reversible re-programing of cell-cell interactions.
Q38945853Review: Current clinical applications of chimeric antigen receptor (CAR) modified T cells
Q89746804Revisiting Immunotherapy: A Focus on Prostate Cancer
Q48906344Rewiring human cellular input-output using modular extracellular sensors.
Q36557169Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor
Q38186628Rise of iPSCs as a cell source for adoptive immunotherapy
Q38575116Role of NK cells in immunotherapy and virotherapy of solid tumors
Q89879065Role of Non-Coding RNAs in the Development of Targeted Therapy and Immunotherapy Approaches for Chronic Lymphocytic Leukemia
Q36186619Role of T lymphocytes in tumor response to radiotherapy
Q37606102Role of immune cells in pancreatic cancer from bench to clinical application: An updated review
Q26748775Role of the tumor microenvironment in mature B-cell lymphoid malignancies
Q41973053SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy
Q50026427Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.
Q91774706Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients
Q44057238Safety and stability of retrovirally transduced chimeric antigen receptor T cells
Q47667620Safety strategies of genetically engineered T cells in cancer immunotherapy
Q37713686Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
Q27022436Science gone translational: the OX40 agonist story
Q35818365Seatbelts in CAR therapy: How Safe Are CARS?
Q94028635Selected Comments submitted by panelists for the August 6, 2013 Public Workshop for the IOM RAC Review Committee
Q92063627Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression
Q91844545Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth
Q90216600Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification
Q40167916Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation
Q37677416Setting the target for pemphigus vulgaris therapy
Q41242075Shedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting.
Q38357127Shifting paradigms in the treatment of chronic lymphocytic leukemia
Q27011688Signaling at neuro/immune synapses
Q95832157Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
Q26744654Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy
Q38203856Significance of interleukin-13 receptor alpha 2-targeted glioblastoma therapy.
Q36938866Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.
Q99604005Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Q92959947Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation
Q45849227Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
Q40714447Site-specific integration of CAR gene into Jurkat T cells with a linear close-ended AAV-based DNA vector for CAR-T engineering
Q35648352Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations
Q30535187Sleeping beauty system to redirect T-cell specificity for human applications
Q36474226Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma
Q45887249Specificity redirection by CAR with human VEGFR-1 affinity endows T lymphocytes with tumor-killing ability and anti-angiogenic potency
Q89991865Sponsorship and Funding for Gene Therapy Trials in the United States
Q92348600State-of-the-art for CAR T-cell therapy for chronic lymphocytic leukemia in 2019
Q37540913Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis
Q38364522Stem cell state and the epithelial-to-mesenchymal transition: Implications for cancer therapy
Q38688055Stem cell transplantation in multiple myeloma and other plasma cell disorders (report from an EBMT preceptorship meeting).
Q34511615Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies
Q52691832Strategies for Increasing Pancreatic Tumor Immunogenicity.
Q88569964Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities
Q38055143Strategies for enhancing vaccine-induced CTL antitumor immune responses
Q33655849Strategies to genetically engineer T cells for cancer immunotherapy
Q46157495Strong and sustained effector function of memory- versus naïve-derived T cells upon T-cell receptor RNA transfer: implications for cellular therapy
Q38527924Structure, development, preclinical and clinical efficacy of blinatumomab in acute lymphoblastic leukemia
Q58797496Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice
Q97648307Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
Q38818477Super natural killer cells that target metastases in the tumor draining lymph nodes
Q97646320Superior Expansion and Cytotoxicity of Human Primary NK and CAR-NK Cells from Various Sources via Enriched Metabolic Pathways
Q40782944Superior Therapeutic Index in Lymphoma Therapy: CD30(+) CD34(+) Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
Q39413297Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells
Q92696727Survival outcomes and efficacy of autologous CD19 chimeric antigen receptor-T cell therapy in the patient with diagnosed hematological malignancies: a systematic review and meta-analysis
Q40740910Sustained, localized transgene expression mediated from lentivirus-loaded biodegradable polyester elastomers
Q38805497Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing
Q35057524Synthetic biology for therapeutic applications
Q51037564Synthetic biology: Sensing with modular receptors.
Q90608633Synthetic immunity by remote control
Q26826954Synthetic therapeutic gene circuits in mammalian cells
Q91663735Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery
Q64066337Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
Q39006805Systemic Immunity Is Required for Effective Cancer Immunotherapy
Q37584747Systems approaches to human autoimmune diseases
Q39828587T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients
Q36642440T Cell Vaccinology: Beyond the Reflection of Infectious Responses
Q37066770T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells
Q37308616T cell activation is determined by the number of presented antigens
Q38912251T cell immunoglobulin domain and mucin domain-3 as an emerging target for immunotherapy in cancer management
Q48188087T cell modulation in immunotherapy for hematological malignancies
Q92245345T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance
Q40895848T cell therapies-are T memory stem cells the answer?
Q38068003T cell-based gene therapy of cancer
Q91522807T cell-engaging therapies - BiTEs and beyond
Q34893030T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression.
Q36300730T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells
Q40186710T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
Q35483599T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo
Q40096913T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma
Q46045077T cells expressing chimeric antigen receptor promote immune tolerance.
Q37466219T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
Q39387987T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term
Q39258646T cells redirected to EphA2 for the immunotherapy of glioblastoma
Q38564461T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma
Q24632975T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
Q92932341T lymphocytes against solid malignancies: winning ways to defeat tumours
Q26786661T-Cell Therapy: Options for Infectious Diseases
Q18614829T-Cells
Q52668512T-bet promotes potent antitumor activity of CD4+ CAR T cells.
Q27678265T-cell Receptor Specificity Maintained by Altered Thermodynamics
Q38169656T-cell adoptive immunotherapy for acute lymphoblastic leukemia
Q26826830T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect
Q60933774T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target
Q42195075T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating chemotherapy-resistant B-cell lymphoma cells overexpressing survivin induced by BMI-1.
Q42549120T-cell immunotherapy: looking forward
Q30491565T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas.
Q92825957T-cell receptor gene therapy targeting melanoma-associated antigen-A4 by silencing of endogenous TCR inhibits tumor growth in mice and human
Q89966656T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Q42228950TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer
Q92285876TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product
Q37065561TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy
Q37137932Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Q90395831Targeted Therapies in CLL: Monotherapy Versus Combination Approaches
Q37395790Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia
Q34748489Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells
Q34270375Targeted immunotherapy of cancer with CAR T cells: achievements and challenges.
Q38331701Targeted therapy for chronic lymphocytic leukemia: current status and future directions
Q35076449Targeted treatment for chronic lymphocytic leukemia: clinical potential of obinutuzumab
Q47850217Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Q94545537Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
Q38963420Targeting Immune Checkpoints in Hematologic Malignancies
Q49290997Targeting T-cell malignancies using anti-CD4 CAR NK-92 cells.
Q39177087Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment
Q99587532Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?
Q26798062Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date
Q33555573Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity
Q39026731Targeting high-grade B cell lymphoma with CD19-specific T cells
Q39149196Targeting neoantigens to augment antitumour immunity
Q39381907Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
Q34329186Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.
Q35661999Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells
Q38120535Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy
Q39318470Targeting the MAGE A3 antigen in pancreatic cancer
Q47409813Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
Q34550649Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
Q91142708Targeting the niche: depleting haemopoietic stem cells with targeted therapy
Q27026329Targeting the tumor vasculature to enhance T cell activity
Q38601568Targeting tumor suppressor genes for cancer therapy
Q38214095Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
Q53106234Team science on a smaller scale: Innovative ways investigators on both coasts are taking on cancer.
Q30591778Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8(+) T cells
Q38225542Th17 cells in cancer: the ultimate identity crisis.
Q45419347The Anti-Tumor Effects of M1 Macrophage-Loaded Poly (ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma
Q41442041The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies
Q64118716The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
Q39115858The Flipside of the Power of Engineered T Cells: Observed and Potential Toxicities of Genetically Modified T Cells as Therapy
Q36055223The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
Q57492021The Potential of CAR T Cell Therapy in Pancreatic Cancer
Q39130457The Principles of Engineering Immune Cells to Treat Cancer
Q36547199The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies
Q36535465The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies
Q97525776The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
Q39042442The Safety of available immunotherapy for the treatment of glioblastoma.
Q45821005The Value of Cancer Immunotherapy Summit at the 2016 Society for Immunotherapy of Cancer 31st anniversary annual meeting.
Q47438165The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy
Q28646882The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1(+) cancer therapy
Q57177485The application of CAR-T cell therapy in hematological malignancies: advantages and challenges
Q34036213The basic principles of chimeric antigen receptor design
Q28083266The biology behind PI3K inhibition in chronic lymphocytic leukaemia
Q38175297The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells.
Q53673922The clinical potential for koff-rate measurement in adoptive immunotherapy.
Q35788245The development of potential antibody-based therapies for myeloma
Q58695003The efficacy and safety of anti-CD19/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis
Q92124367The emerging roles of inflammasome-dependent cytokines in cancer development
Q40478697The epigenetic landscape of T cell exhaustion.
Q38355743The evolving role of hematopoietic cell transplantation in chronic lymphocytic leukemia.
Q64264660The evolving role of immuno-oncology for the treatment of head and neck cancer
Q33993529The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer
Q38775177The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
Q35832365The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting
Q104064819The global chimeric antigen receptor T (CAR-T) cell therapy patent landscape
Q61449409The growing role of precision and personalized medicine for cancer treatment
Q38950791The growing world of CAR T cell trials: a systematic review
Q96952246The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
Q34637799The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties
Q34309388The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors
Q57961866The immunological synapse
Q38267385The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.
Q41551980The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Q89515386The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19
Q98164353The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma
Q42370576The new era of nanotechnology, an alternative to change cancer treatment
Q36408432The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.
Q26799896The past, present and future of immunotherapy against tumor
Q38541019The pharmacology of second-generation chimeric antigen receptors.
Q39039017The promise of chimeric antigen receptor T cells (CARTs) in leukaemia
Q38764944The prospects and promise of chimeric antigen receptor immunotherapy in multiple myeloma
Q58619853The right touch: design of artificial antigen-presenting cells to stimulate the immune system
Q36584814The role of B7 family molecules in hematologic malignancy
Q38021845The role of antigen-specific and non-specific immunotherapy in the treatment of cancer
Q58605622The role of biosimilars in value-based oncology care
Q92454632The second genome: Effects of the mitochondrial genome on cancer progression
Q30243968The shrinking role of chemotherapy in the treatment of chronic lymphocytic leukemia
Q38039112The split nature of tumor-infiltrating leukocytes: Implications for cancer surveillance and immunotherapy
Q58924840The swinging pendulum of cancer immunotherapy personalization
Q38831232The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease
Q59360113The use of chimeric antigen receptor T cells in patients with non-Hodgkin lymphoma
Q57278479Therapeutic Impact of Immune Responses in Cancer
Q58787586Therapeutic Vaccines for Genitourinary Malignancies
Q50988785Therapeutic cancer vaccines.
Q26779938Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy
Q92749886Therapeutic potential of CRISPR/Cas9 gene editing in engineered T-cell therapy
Q38124065Therapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond
Q34560877Therapeutic targets for neuroblastomas
Q48355318Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma.
Q36110355Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
Q48175410Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells.
Q36583710Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning
Q42379534Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent
Q37113074Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
Q34240817Toward synthetic biology with engineered T cells: a long journey just begun
Q38026409Towards a 'cure' for IBD.
Q34640562Towards an HIV cure: a global scientific strategy
Q38025094Towards curative cancer immunotherapy: overcoming posttherapy tumor escape
Q36307671Toxicities Associated With Adoptive T-Cell Transfer for Cancer
Q27008140Toxicities of Immunotherapy for the Practitioner
Q37058104Toxicities of chimeric antigen receptor T cells: recognition and management
Q34343346Toxicity management for patients receiving novel T-cell engaging therapies.
Q52374505Transcription Factor Target Gene Network governs the Logical Abstraction Analysis of the Synthetic Circuit in Leishmaniasis.
Q92765927Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL
Q38839878Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors
Q34625543Transplantation in chronic lymphocytic leukemia: does it still matter in the era of novel targeted therapies?
Q38094968Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.
Q39448180Treating breast cancer with cell-based approaches: an overview.
Q38366422Treatment for metastatic melanoma: a new and evolving era.
Q89700420Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report
Q45870820Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.
Q49843910Treatment of Richter's Syndrome.
Q36114222Treatment of a solid tumor using engineered drug-resistant immunocompetent cells and cytotoxic chemotherapy
Q39784230Treatment of advanced leukemia in mice with mRNA engineered T cells
Q38573785Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?
Q39111432Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
Q90465660Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report
Q64891187Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector: a unicentre phase I/II clinical trial protocol.
Q91768573Treg cell-based therapies: challenges and perspectives
Q42702234Trial Watch: Adoptive cell transfer for anticancer immunotherapy
Q26785545Trial Watch: Adoptive cell transfer for oncological indications
Q36057432Trial Watch: Adoptive cell transfer immunotherapy
Q47887134Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia with Novel Targeted Agents.
Q38756750Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy.
Q33689478Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer
Q46090703Tumor immunology and cancer immunotherapy: summary of the 2014 SITC primer.
Q35757397Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
Q91973610Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy
Q64949581Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies.
Q35673845Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition
Q41977894Tumor-associated antigens for specific immunotherapy of prostate cancer
Q38217028Tumor-infiltrating lymphocyte therapy for melanoma: rationale and issues for further clinical development
Q35613148Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma
Q34823085Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells
Q50063348Tumor-specific allogeneic cells for cancer therapy.
Q54978507Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density.
Q36218880Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Q47709474Two is better than one: advances in pathogen-boosted immunotherapy and adoptive T-cell therapy
Q34892977Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest
Q36075677Type17 T-cells in central nervous system autoimmunity and tumors.
Q41774005T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation.
Q38514503Umbilical cord blood graft engineering: challenges and opportunities.
Q36746512Umbilical cord blood transplantation supported by third-party donor cells: rationale, results, and applications
Q45872498Unbiased Identification of T-Cell Receptors Targeting Immunodominant Peptide-MHC Complexes for T-Cell Receptor Immunotherapy.
Q40930095Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
Q59326961Universal CARs, universal T cells, and universal CAR T cells
Q39224315Unleashing the immune response against childhood solid cancers
Q89548367Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
Q27011297Using gene therapy to manipulate the immune system in the fight against B-cell leukemias
Q36747346Using macrophage activation to augment immunotherapy of established tumours
Q55122008Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma.
Q39043404Vaccine strategies for the treatment of lymphoma: preclinical progress and clinical trial update
Q30390904Vaccines, new opportunities for a new society
Q28395507Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors
Q33586329Vector production in an academic environment: a tool to assess production costs
Q55347731Versatile CAR T-cells for cancer immunotherapy.
Q34045831Versatile strategy for controlling the specificity and activity of engineered T cells
Q38188591Viral lymphomagenesis: from pathophysiology to the rationale for novel therapies
Q36642808Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses.
Q28066228Virotherapy: cancer gene therapy at last?
Q49835983What is the role of apheresis technology in stem cell transplantation?
Q37560324What new immunotherapeutic techniques are currently being investigated for the treatment of melanoma?
Q64251378When CAR Meets Stem Cells
Q58570505Which biological systems should be engineered?
Q45117306Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer
Q38049970Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions
Q28078210Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights
Q39944717Zoom Zoom: racing CARs for multiple myeloma
Q89062934[Advances in immunotherapy of acute myeloid leukemia by using chimeric antigen receptor modified T cells]
Q52644666[An experimental study of CD4 targeted chimeric antigen receptor modified T cell with anti-lymphoma activity].
Q89062936[Anti-CD19 chimeric antigen receptor T cells (CART-19) for hemotological malignancies therapy]
Q50045993[Cytotoxity of pomalidomide combined CAR-T cell for multiple myeloma cell RPMI8226 and U266].
Q88251354[Donor- derived CD19 chimeric antigen receptor T cells for relapsed B cell malignancies after allogeneic hematopoietic stem cell transplantations]
Q90389192[How I treat CAR-T cell therapy-related cytokine release syndrome]
Q50034111[Immunotherapy of cancer with checkpoint inhibitors : Not only in malignant melanoma].
Q49791966[Management of cytokine release syndrome during chimeric antigen receptor-modified T cell therapy].
Q53656857[New immunotherapeutic approaches in oncology and hematology].
Q50026306[Progress in clinical studies of chimeric antigen receptor engineered T cells for treatment of childhood cancer].
Q50042696[Research progress of the side effect and application prospects of CAR-T cells in the treatment of malignant tumors].
Q49792109[The specific cytotoxicities of chimeric antigen receptor-engineered T cells on different lymphomas].
Q39013357mRNA Cancer Vaccines
Q47141728mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting
Q89540099miR-155 Overexpression in OT-1 CD8+ T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen

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