Cancer Immunotherapy Using γδT Cells: Dealing with Diversity

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Cancer Immunotherapy Using γδT Cells: Dealing with Diversity is …
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P356DOI10.3389/FIMMU.2014.00601
P932PMC publication ID4238375
P698PubMed publication ID25477886
P5875ResearchGate publication ID269186649

P2093author name stringJürgen Kuball
Wouter Scheper
Zsolt Sebestyen
P2860cites workBroad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICBQ22009950
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICAQ22010440
Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T LymphocytesQ56827951
Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behçet's disease patients and healthy controlsQ56899634
Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinomaQ57949352
Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cellsQ59310681
Harnessing γδ T cells in anticancer immunotherapyQ59387577
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptorQ60241555
A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segmentQ63968530
Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humansQ69737613
Clonal expansions of V delta 1+ and V delta 2+ cells increase with age and limit the repertoire of human gamma delta T cellsQ72119438
Selective lysis of autologous tumor cells by recurrent gamma delta tumor-infiltrating lymphocytes from renal carcinomaQ72133128
T-cell receptor V delta gene usage by tumour reactive gamma delta T lymphocytes infiltrating human lung cancerQ72362062
Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a microbicidal weapon against Brucella suisQ79174467
Long term disease-free survival in acute leukemia patients recovering with increased gammadelta T cells after partially mismatched related donor bone marrow transplantationQ80196080
Professional antigen-presentation function by human gammadelta T CellsQ81810232
Distinct gene expression in human Vdelta1 and Vdelta2 gammadelta T cells following non-TCR agonist stimulationQ82307107
Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptorsQ83654884
Toll-like receptor expression and function in subsets of human gammadelta T lymphocytesQ84456947
Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumorsQ85012142
γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemiaQ85818563
γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRsQ87389135
MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector functionQ24291528
Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cellsQ24316370
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subsetQ24339540
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemiaQ24594920
Adoptive cell transfer: a clinical path to effective cancer immunotherapyQ24644774
Cancer regression in patients after transfer of genetically engineered lymphocytesQ24654976
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
What lessons can be learned from γδ T cell-based cancer immunotherapy trials?Q26849323
Trial Watch: Tumor-targeting monoclonal antibodies in cancer therapyQ26993238
γδ-T cells: an unpolished sword in human anti-infection immunityQ26994963
Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic MelanomaQ27005902
Six-of-the-best: unique contributions of γδ T cells to immunologyQ27010451
γδ T cells for cancer immunotherapy: A systematic review of clinical trialsQ27021705
Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICAQ27666700
The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T CellsQ27682926
CD1d-lipid antigen recognition by the γδ TCRQ27686847
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populationsQ28142106
Regulation of cutaneous malignancy by gammadelta T cellsQ28188439
KIR: diverse, rapidly evolving receptors of innate and adaptive immunityQ28203441
The biology of NKT cellsQ28277482
Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancerQ28659468
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1Q29616128
Chimeric antigen receptor-modified T cells for acute lymphoid leukemiaQ29620130
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infectionsQ33410795
Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantationQ33562231
Human cytomegalovirus elicits fetal gammadelta T cell responses in uteroQ33795023
CD1-mediated gamma/delta T cell maturation of dendritic cellsQ33963163
gammadelta T cell subsets: a link between TCR and function?Q34005647
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19Q34360292
Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptorQ39544028
NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signals.Q39698695
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicityQ39748029
Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathwayQ40101993
Phase I study of bromohydrin pyrophosphate (BrHPP, IPH 1101), a Vgamma9Vdelta2 T lymphocyte agonist in patients with solid tumorsQ40356007
Activation of V gamma 9V delta 2 T cells by NKG2D.Q40388491
Phosphostim-activated gamma delta T cells kill autologous metastatic renal cell carcinoma.Q40468302
Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study.Q40474302
Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptorsQ41206773
Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptorsQ42086300
Cutting Edge: γδ T Cells Provide Help to B Cells with Altered Clonotypes and Are Capable of Inducing Ig Gene HypermutationQ42798925
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patientsQ43057295
V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenous leukemia cells.Q43162657
A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cellsQ43170735
Gammadelta T cells and the lymphoid stress-surveillance responseQ43496487
Breakthrough of the year 2013. Cancer immunotherapyQ43822796
Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulationQ44305783
Gammadelta T cells for immune therapy of patients with lymphoid malignanciesQ44353687
Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo.Q44575984
Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells.Q44671613
Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokinesQ45195924
Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patientsQ45366854
Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes.Q46004947
Clinical and immunological evaluation of zoledronate-activated Vgamma9gammadelta T-cell-based immunotherapy for patients with multiple myeloma.Q46028184
Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapyQ46240502
Immune suppression by gammadelta T-cells as a potential regulatory mechanism after cancer vaccination with IL-12 secreting dendritic cellsQ50783387
Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cellsQ51423603
CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody productionQ51978896
Human peripheral gammadelta T cells possess regulatory potentialQ52908064
Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.Q54367882
Gammadelta T cells: functional plasticity and heterogeneityQ34659133
Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumoursQ35208161
Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinomaQ35226178
Alpha/beta- and gamma/delta TCR(+) lymphocyte infiltration in necrotising choroidal melanomasQ35311221
Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagementQ35883004
Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.Q36227215
Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial originQ36366439
Self-recognition of CD1 by gamma/delta T cells: implications for innate immunityQ36368376
Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cellsQ36370502
Gamma delta T cells provide an early source of interferon gamma in tumor immunityQ36371404
Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cellsQ36402321
Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cellsQ36403003
γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.Q36473289
Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescenceQ36625669
Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigensQ36732656
Relapse after allogeneic hematopoietic cell therapy.Q36799799
Tumor-Infiltrating γδ T Lymphocytes Predict Clinical Outcome in Human Breast CancerQ36800215
CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemiaQ37098861
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responsesQ37114832
The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbuminQ37266990
Current paradigms for the use of HER2-targeted therapy in early-stage breast cancerQ37373983
Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapyQ37561102
Antibody-modified T cells: CARs take the front seat for hematologic malignanciesQ37723469
Gammadelta T cell effector functions: a blend of innate programming and acquired plasticityQ37764294
Modulation of γδ T cell responses by TLR ligandsQ37874203
Anti-CD20 Antibody Therapy for B-Cell LymphomasQ38012522
The natural and the inducible: interleukin (IL)-17-producing γδ T cellsQ38069721
Regulatory functions of γδ T cellsQ38088501
Immunotherapy with gene-modified T cells: limiting side effects provides new challenges.Q38117268
Hunting for clinical translation with innate-like immune cells and their receptorsQ38171917
Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell ResponsesQ38240851
IL-17A produced by γδ T cells promotes tumor growth in hepatocellular carcinoma.Q39024081
Inhibition of R5-tropic HIV type-1 replication in CD4⁺ natural killer T cells by γδ T lymphocytesQ39324337
Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cellsQ39411262
P921main subjectimmunotherapyQ1427096
P304page(s)601
P577publication date2014-11-20
P13046publication type of scholarly workreview articleQ7318358
P1433published inFrontiers in ImmunologyQ27723748
P1476titleCancer Immunotherapy Using γδT Cells: Dealing with Diversity
P478volume5