Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells

scientific article

Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20021500
P932PMC publication ID2193814
P698PubMed publication ID12538656
P5875ResearchGate publication ID246582970

P50authorGennaro De LiberoQ57368537
P2093author name stringHans-Jürgen Gober
Lucia Mori
Paul Jenö
Lena Angman
Magdalena Kistowska
P2860cites workStructural mechanism for statin inhibition of HMG-CoA reductaseQ27631717
Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune systemQ28140355
Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthaseQ28378368
Regulation of the mevalonate pathwayQ29547763
3-Formyl-1-butyl pyrophosphate A novel mycobacterial metabolite-activating human gammadelta T cellsQ30804064
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.Q31841626
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacityQ33899261
Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathwayQ33953548
Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cellsQ36361082
Biology of the human gamma delta T-cell receptorQ36409474
Escherichia coli produces phosphoantigens activating human gamma delta T cells.Q40772864
Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonatesQ40783969
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cellsQ40942353
Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.Q41289959
Sentinel function of broadly reactive human gamma delta T cellsQ41339837
Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.Q41346251
Reactivity of gamma delta T cells induced by the tumour cell line RPMI 8226: functional heterogeneity of clonal populations and role of GroEL heat shock proteinsQ41617076
In vivo regulation of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphomaQ41669999
Specific triggering of gamma, delta T cells by K562 activates the gamma, delta T cell receptor and may regulate natural killer-like functionQ41687774
Targeting of tumor cells for human gammadelta T cells by nonpeptide antigensQ43775068
Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cellsQ44043116
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.Q44907400
7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts.Q51995258
Antilymphoma activity of human gamma delta T-cells in mice with severe combined immune deficiencyQ67904380
HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cellsQ71031979
Human V gamma 9-V delta 2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolitesQ71918639
Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseQ72037122
Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligandsQ72336933
Activation of the cholesterol pathway and Ras maturation in response to stressQ73171126
Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myelomaQ73971334
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)163-168
P577publication date2003-01-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleHuman T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells
P478volume197

Reverse relations

cites work (P2860)
Q36410082A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1.
Q52731753A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells.
Q36674426A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells
Q38756878A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.
Q46131239A regulatory cross-talk between Vgamma9Vdelta2 T lymphocytes and mesenchymal stem cells
Q34002174A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes
Q55339238ABCA1, apoA-I, and BTN3A1: A Legitimate Ménage à Trois in Dendritic Cells.
Q40596798ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing
Q57309120Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells
Q35222179Activated human gammadelta T cells as stimulators of specific CD8+ T-cell responses to subdominant Epstein Barr virus epitopes: potential for immunotherapy of cancer
Q90398665Activation of Human γδ T Cells: Modulation by Toll-Like Receptor 8 Ligands and Role of Monocytes
Q54373964Addition of zoledronic acid to neoadjuvant chemotherapy does not enhance tumor response in patients with HER2-negative stage II/III breast cancer: the NEOZOTAC trial (BOOG 2010-01).
Q38730126Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer
Q99571885Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study
Q40146526Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model
Q38198742Allogeneic chimeric antigen receptor-modified cells for adoptive cell therapy of cancer
Q90090369Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset
Q40514344Alpha-bisabolol, not a matter for cancer therapy. Commentary: "Research on the immunosuppressive activity of ingredients contained in sunscreens"
Q51145613Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine.
Q37012505Altered cord blood gammadelta T cell repertoire in Nigeria: possible impacts of environmental factors on neonatal immunity
Q38798990Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells
Q39158802Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas.
Q90616712An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
Q36759195Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate
Q92438871Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators
Q41578214Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma.
Q90430104Anti-CD3 Fab Fragments Enhance Tumor Killing by Human γδ T Cells Independent of Nck Recruitment to the γδ T Cell Antigen Receptor
Q33920919Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug
Q36194639Anti-lymphoma effect of gammadelta T cells
Q46589194Anti-tumor cytotoxicity of gammadelta T cells expanded from peripheral blood cells of patients with myeloma and lymphoma
Q38051730Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside
Q37729133Anti-γδ TCR antibody-expanded γδ T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies
Q37794160Anticancer Properties of Zoledronic Acid
Q24675038Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses
Q40620344Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo
Q64105155Aquatic Exercise at Thermoneutral Water Temperature Enhances Antitumor Immune Responses
Q91675416Assessment of Immune Response Following Dendritic Cell-Based Immunotherapy in Pediatric Patients With Relapsing Sarcoma
Q38149725At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies
Q38151057At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias
Q36040498Azathioprine therapy selectively ablates human Vδ2⁺ T cells in Crohn's disease.
Q50420977BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC).
Q37380386BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia
Q40070853BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain
Q40115139Bacillus Calmette-Guérin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells
Q98735436Beneficial Effect of Antibiotics and Microbial Metabolites on Expanded Vδ2Vγ9 T Cells in Hepatocellular Carcinoma Immunotherapy
Q38848635Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation
Q48359042Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations.
Q27685257Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
Q28660812Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells
Q90187881Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing
Q54268399Butyrophilin3A proteins and Vγ9Vδ2 T cell activation.
Q50308633Butyrophilins: an important new element of resistance
Q92853203CAR-Based Strategies beyond T Lymphocytes: Integrative Opportunities for Cancer Adoptive Immunotherapy
Q26782520CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity
Q48331916CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells
Q35750453Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
Q38283536Cancer Immunotherapy Using γδT Cells: Dealing with Diversity
Q97653023Cancer immunotherapy with γδ T cells: many paths ahead of us
Q34493921Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas
Q34769652Chemotherapy sensitizes colon cancer initiating cells to Vγ9Vδ2 T cell-mediated cytotoxicity
Q35208161Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours
Q98465659Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells
Q37127038Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid.
Q46568857Complementary function of gamma delta T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens
Q44952617Contribution of complementarity-determining region 3 of the T-cell receptor Vdelta2 chain to the recognition of aminobisphosphonates by human gammadelta T-cells
Q33554677Cord blood Vγ2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity
Q90681174Cryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors
Q47100174Current Advances in γδ T Cell-Based Tumor Immunotherapy
Q49829282Current Status of Gene Engineering Cell Therapeutics
Q60241555Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor
Q38217512Cytotoxic and regulatory properties of circulating Vδ1+ γδ T cells: a new player on the cell therapy field?
Q39092574Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma
Q33436859DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells
Q55279130Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL-NKG2D Axis.
Q27026152Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic
Q37344573Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vgamma2Vdelta 2 TCR.
Q36199422Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
Q64060735Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell
Q40053061Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.
Q50550722Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer.
Q27021646Diversity of γδ T-cell antigens
Q35046087Do γδ T cells predict osteonecrosis of the jaw?
Q46169443Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities
Q46485959Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells
Q52367095Early Reconstitution of NK and γδ T Cells and Its Implication for the Design of Post-Transplant Immunotherapy.
Q24321574Ecto-F1-ATPase and MHC-class I close association on cell membranes
Q34428768Ecto-F₁-ATPase: a moonlighting protein complex and an unexpected apoA-I receptor
Q41061926Editorial: "Recent Advances in Gamma/Delta T Cell Biology: New Ligands, New Functions, and New Translational Perspectives".
Q54626514Editorial: Vγ9Vδ2 T cells: triple costimulation goes the distance.
Q36750128Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report
Q35090079Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire
Q45296414Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma.
Q37441693Effects of RANKL-Targeted Therapy in Immunity and Cancer
Q96303605Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells
Q26781175Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
Q90044346Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors
Q44653216Enhancement of BCG-induced Th1 immune response through Vgamma9Vdelta2 T cell activation with non-peptidic drugs
Q37655345Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation
Q64103688Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells
Q64057109Ex Vivo Expanded Human Vγ9Vδ2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth
Q37162910Ex vivo restimulation of human PBMC expands a CD3+CD4-CD8- γδ+ T cell population that can confound the evaluation of CD4 and CD8 T cell responses to vaccination.
Q55008660Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility.
Q39585660Expansion of human peripheral blood γδ T cells using zoledronate
Q47666620Expansion of human γδ T cells for adoptive immunotherapy using a bisphosphonate prodrug
Q39602547Expression and function of PD-1 in human γδ T cells that recognize phosphoantigens
Q41981818Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells
Q55111474Fish Lymphocytes: An Evolutionary Equivalent of Mammalian Innate-Like Lymphocytes?
Q38352469Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation
Q35156294Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
Q57244549Functional Expression of NOD2 in Freshly Isolated Human Peripheral Blood γδ T Cells
Q97644530Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity
Q34975891Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys
Q33825327Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits
Q37587832Gammadelta T cells as immune effectors against high-grade gliomas
Q38945041HIV infection: focus on the innate immune cells.
Q37072016HMBPP Analog Prodrugs Bypass Energy-Dependent Uptake To Promote Efficient BTN3A1-Mediated Malignant Cell Lysis by Vγ9Vδ2 T Lymphocyte Effectors
Q34018807HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity
Q42132237HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
Q37152701Hallmarks of Tissue-Resident Lymphocytes
Q37409283Harnessing innate and adaptive immunity for adoptive cell therapy of renal cell carcinoma
Q27027547Harnessing the power of Vδ2 cells in cancer immunotherapy
Q36734208Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate
Q48232215Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology
Q33455830Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells
Q42740131How to exploit stress-related immunity against Hodgkin's lymphoma: Targeting ERp5 and ADAM sheddases.
Q39396311Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity.
Q50927130Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15.
Q35738915Human gamma delta T cells: Evolution and ligand recognition
Q36908780Human gamma delta T cells: candidates for the development of immunotherapeutic strategies
Q41812496Human gamma delta T lymphocytes for immunotherapeutic strategies against cancer
Q45002846Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity
Q54940475Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias.
Q38027044Human γδ T-cell responses in infection and immunotherapy: common mechanisms, common mediators?
Q37714642Human γδT-cell subsets and their involvement in tumor immunity.
Q38171917Hunting for clinical translation with innate-like immune cells and their receptors
Q38040743IL-17-producing γδ T cells and innate lymphoid cells
Q47217155IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population.
Q47422433IL-23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome
Q48031093IL-33-expanded human Vγ9Vδ2 T cells have anti-lymphoma effect in a mouse tumor model
Q33322644Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy
Q92757627Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells
Q38752243Immune-mediated syndromes following intravenous bisphosphonate therapy
Q38108390Immunologic microenvironment and personalized treatment in multiple myeloma.
Q36871994Immunomodulating role of bisphosphonates on human gamma delta T cells: an intriguing and promising aspect of their antitumour activity
Q37822747Immunotherapy targeting colon cancer stem cells
Q39317720Impaired function of gamma-delta lymphocytes in melanoma patients
Q55311835Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer.
Q87518258In vitro effects of bisphosphonates on chemotaxis, phagocytosis, and oxidative burst of neutrophil granulocytes
Q40076011In vitro expansion of gamma delta T cells with anti-myeloma cell activity by Phosphostim and IL-2 in patients with multiple myeloma
Q43057295In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients
Q52780147In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment.
Q35889808Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism
Q39588867Inhibition of human gamma delta [corrected] T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer
Q53008599Inhibition of human γδ T cell proliferation and effector functions by neutrophil serine proteases.
Q37737540Insights into Local Tumor Microenvironment Immune Factors Associated with Regression of Cutaneous Melanoma Metastases by Mycobacterium bovis Bacille Calmette-Guérin
Q47346919Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells
Q64275741Interleukin-18 in Health and Disease
Q84803680Interplay of T-cell receptor and interleukin-2 signalling in Vγ2Vδ2 T-cell cytotoxicity
Q37703392Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer.
Q37605637Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion
Q37038276Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma
Q24339540Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset
Q36853886L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer
Q34372167Large-scale expansion of γδ T cells and peptide-specific cytotoxic T cells using zoledronate for adoptive immunotherapy
Q38013197Licensing of killer dendritic cells in mouse and humans: functional similarities between IKDC and human blood γδ T-lymphocytes
Q97692776Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
Q39758159Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators
Q40106388Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.
Q34395222Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vγ9Vδ2 T cells
Q61727663Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
Q36883879Mechanisms of the antitumor activity of human Vγ9Vδ2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma.
Q34560345Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity.
Q40065267Metabolism in Immune Cell Differentiation and Function.
Q57300154Mevalonate Metabolism in Cancer Stemness and Trained Immunity
Q46592108Mevalonate metabolism governs cancer immune surveillance.
Q28208141Microbial isoprenoid biosynthesis and human gammadelta T cell activation
Q55237064Molecular Determinants of Target Cell Recognition by Human γδ T Cells.
Q34819275Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells
Q50932570Monocytes and γδ T cells control the acute-phase response to intravenous zoledronate: insights from a phase IV safety trial.
Q37122974Mycobacteria and innate cells: critical encounter for immunogenicity
Q49333274NK Cells and γδT Cells for Relapse Protection After Allogeneic Hematopoietic Cell Transplantation (HCT).
Q39798606NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors
Q92444661Nanoformulated Zoledronic Acid Boosts the Vδ2 T Cell Immunotherapeutic Potential in Colorectal Cancer
Q90534741New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity
Q37481361New frontiers in cell-based immunotherapy of cancer.
Q34487392Nuclear hormone receptors put immunity on sterols
Q38818271Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo.
Q34502899Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment
Q36348587Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II
Q42183397Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.
Q36334874Peripheral gammadelta T-lymphocytes as an innovative tool in immunotherapy for metastatic renal cell carcinoma
Q38934681Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells
Q37226209Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma.
Q50708147Phenotypic characterization and prognostic impact of circulating γδ and αβ T-cells in metastatic malignant melanoma.
Q34970077Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones
Q40093467Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation
Q37226687Photoaffinity antigens for human gammadelta T cells
Q38496996Pilot study on the use of zoledronic acid to prevent bone loss in allo-SCT recipients
Q34652408Plasticity of γδ T Cells: Impact on the Anti-Tumor Response
Q57300020Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression
Q35896206Potential of human gammadelta T lymphocytes for immunotherapy of cancer
Q38052064Potential of human γδ T cells for immunotherapy of osteosarcoma
Q34162359Potential pathophysiological mechanisms in osteonecrosis of the jaw.
Q64060934Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme
Q34595188Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells.
Q38728528Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody.
Q33832188Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques
Q40355238Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab
Q38890450Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy.
Q57024595Protective Role of T Cells in Different Pathogen Infections and Its Potential Clinical Application
Q41450925RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.
Q41807960Radiation-induced DNA damage and repair in human gammadelta and alphabeta T-lymphocytes analysed by the alkaline comet assay
Q44898932Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin
Q26823185Regeneration of stalled immune responses to transformed and infected cells using γδ T cells
Q92405201Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells
Q38787725Regulatory and effector functions of gamma-delta (γδ) T cells and their therapeutic potential in adoptive cellular therapy for cancer
Q88008277Regulatory functions of γδ T cells
Q37731978Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells
Q37854072Requisite considerations for successful adoptive immunotherapy with engineered T-lymphocytes using tumor antigen-specific T-cell receptor gene transfer
Q37279963RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor
Q36388793Role of apolipoproteins in gammadelta and NKT cell-mediated innate immunity.
Q27026700Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus
Q38093573Roles of γδ T cells in the pathogenesis of autoimmune diseases
Q28287583Self/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue?
Q35000371Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells.
Q34077388Sensitization of ovarian carcinoma cells with zoledronate restores the cytotoxic capacity of Vγ9Vδ2 T cells impaired by the prostaglandin E2 immunosuppressive factor: implications for immunotherapy
Q36845046Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells
Q37018333Significance and impact of bisphosphonate-induced acute phase responses
Q27010451Six-of-the-best: unique contributions of γδ T cells to immunology
Q35935862Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome
Q39807695Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.
Q40953833Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism.
Q36920135Suppression of CYP2B induction by alendronate-mediated farnesyl diphosphate synthase inhibition in primary cultured rat hepatocytes
Q26865650T cell recognition of non-peptidic antigens in infectious diseases
Q38398684T lymphocyte regulation by mevalonate metabolism.
Q90290705TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells
Q92304043Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions
Q38179172Targeting gamma delta T cells for cancer immunotherapy: bench to bedside
Q28659468Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
Q53238656Targeting myeloma-osteoclast interaction with Vγ9Vδ2 T cells.
Q42211743The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells.
Q27682926The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells
Q28069991The Role of γδ T Cells in Fibrotic Diseases
Q26765027The Role of γδ T Cells in Systemic Lupus Erythematosus
Q38370910The T cell antigen receptor: the Swiss army knife of the immune system.
Q46483041The Vgamma2/Vdelta2 T-cell repertoire in Macaca fascicularis: functional responses to phosphoantigen stimulation by the Vgamma2/Jgamma1.2 subset
Q34741552The Vγ9Vδ2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells
Q37847339The backbone of progress--preclinical studies and innovations with zoledronic acid
Q24684244The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins
Q50892187The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region.
Q42155981The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
Q37808268The crossover of bisphosphonates to cancer therapy
Q92628379The features of circulating and tumor-infiltrating γδ T cells in melanoma patients display critical perturbations with prognostic impact on clinical outcome
Q37172099The invisible arm of immunity in common cancer chemoprevention agents
Q38016451The multifunctionality of human Vγ9Vδ2 γδ T cells: clonal plasticity or distinct subsets?
Q37359263The potential role of CD16+ Vγ2Vδ2 T cell-mediated antibody-dependent cell-mediated cytotoxicity in control of HIV type 1 disease
Q26859775The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
Q60241510The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
Q59806979Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells
Q54219852Towards Deciphering the Hidden Mechanisms That Contribute to the Antigenic Activation Process of Human Vγ9Vδ2 T Cells.
Q93162748Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies
Q38839878Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors
Q37096879Treatment of breast cancer with bone metastasis: bisphosphonate treatment - current and future
Q44732034Tripartite immune cell co-operation in the Bacillus Calmette Guérin-induced activation of γδ T cells
Q42086300Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptors
Q38287973Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment.
Q37706085Tumor-activated TCRγδ⁺ T cells from gastric cancer patients induce the antitumor immune response of TCRαβ⁺ T cells via their antigen-presenting cell-like effects.
Q40618363Uncoupling between Immunological Synapse Formation and Functional Outcome in Human γδ T Lymphocytes
Q37990046Understanding the complexity of γδ T-cell subsets in mouse and human
Q52657143Valproic Acid Combined with Zoledronate Enhance γδ T Cell-Mediated Cytotoxicity against Osteosarcoma Cells via the Accumulation of Mevalonate Pathway Intermediates.
Q46808881Vdelta2 T-lymphocyte responses in cord blood samples from Italy and Côte d'Ivoire
Q34749889Vgamma2Vdelta2 T Cell Receptor recognition of prenyl pyrophosphates is dependent on all CDRs
Q36237901Vgamma9Vdelta2 T cell-mediated non-cytolytic antiviral mechanisms and their potential for cell-based therapy
Q92573018Vitamin C promotes the proliferation and effector functions of human γδ T cells
Q42187331Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells
Q42237075Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos).
Q98177693Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer
Q40150564Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
Q37876363Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside.
Q42214986Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6.
Q55310862Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.
Q40252845Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity.
Q38986536Zoledronic acid causes γδ T cells to target monocytes and down-modulate inflammatory homing
Q39558094Zoledronic acid enhances Vδ2 T-lymphocyte antitumor response to human glioma cell lines
Q36708315Zoledronic acid in the management of metastatic bone disease.
Q59242355Zoledronic acid modulates maturation of human monocyte-derived dendritic cells
Q40213985Zoledronic acid renders human M1 and M2 macrophages susceptible to Vδ2(+) γδ T cell cytotoxicity in a perforin-dependent manner.
Q47270508Zoledronic acid sensitizes rhabdomyosarcoma cells to cytolysis mediated by human γδ T cells
Q39424272Zoledronic acid to prevent and treat cancer metastasis: new prospects for an old drug
Q36803818Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells
Q36429414Zoledronic acid: past, present and future roles in cancer treatment
Q26995102γδ T Cell Immunotherapy-A Review
Q37836561γδ T cell receptor ligands and modes of antigen recognition
Q35799192γδ T cells and epigenetic drugs: A useful merger in cancer immunotherapy?
Q37576001γδ T cells and their potential for immunotherapy
Q38262257γδ T cells as a potential tool in colon cancer immunotherapy
Q34496948γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection.
Q27021705γδ T cells for cancer immunotherapy: A systematic review of clinical trials
Q38602555γδ T cells in cancer
Q90783584γδ T cells in cancer: a small population of lymphocytes with big implications
Q37870836γδ T-cell immunotherapy for lung cancer.
Q35634919γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes
Q92005867γδ T-cell responses during HIV infection and antiretroviral therapy
Q37871905γδ T-cells: cross-talk between innate and adaptive immunity
Q85818563γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia
Q38271585γδ T Lymphocytes as a First Line of Immune Defense: Old and New Ways of Antigen Recognition and Implications for Cancer Immunotherapy