Role of the tumor microenvironment in mature B-cell lymphoid malignancies

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Role of the tumor microenvironment in mature B-cell lymphoid malignancies is …
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scholarly articleQ13442814

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P356DOI10.3324/HAEMATOL.2015.139493
P932PMC publication ID5004369
P698PubMed publication ID27132279

P50authorChan Yoon CheahQ43162115
Thorsten ZenzQ46329248
Susan O'BrienQ66370727
Loretta J NastoupilQ87358443
Randy D GascoyneQ87831803
Nathan H FowlerQ88014314
Sattva S NeelapuQ91522188
Catherine M BollardQ91774704
Wyndham H. WilsonQ110350523
Kieron DunleavyQ114521842
Paolo GhiaQ38804038
Michael A. CurranQ39370315
P2093author name stringCliona Grant
John Gribben
Stephen Ansell
Richard Little
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Circulating myeloid-derived suppressor cells correlate with clinical outcome in Hodgkin Lymphoma patients treated up-front with a risk-adapted strategy.Q51037023
CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical Hodgkin lymphoma.Q53095335
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IL-18 Induces PD-1-Dependent Immunosuppression in CancerQ57556330
Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphomaQ57631157
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Bone marrow and peripheral blood involvement in mantle cell lymphomaQ74605653
Macrophage-derived chemokine expression in classical Hodgkin's lymphoma: application of tissue microarraysQ77351222
Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patientsQ79394017
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Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphomaQ84847984
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High CD20+ background cells predict a favorable outcome in classical Hodgkin lymphoma and antagonize CD68+ macrophagesQ87513562
Safety and activity of lenalidomide and rituximab in untreated indolent lymphoma: an open-label, phase 2 trialQ33418964
PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphomaQ33690142
Tumor-associated macrophages and survival in classic Hodgkin's lymphomaQ33962334
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemiaQ34009003
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivoQ34029869
Oncology meets immunology: the cancer-immunity cycleQ34037625
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptorQ34041792
Inhibitors of BCR signalling interrupt the survival signal mediated by the micro-environment in mantle cell lymphomaQ34042407
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedQ34080914
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signalsQ34184717
Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 studyQ34240404
Pathogenesis of human B cell lymphomasQ34245261
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trialQ34391446
Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.Q34402339
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemiaQ34542102
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IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cellsQ34636880
Regulation of B-cell fate by antigen-receptor signalsQ35014068
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).Q35064910
Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemiaQ35146081
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITKQ35156866
Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphomaQ35220644
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemiaQ35671227
CD40 activation: potential for specific immunotherapy in B-CLL.Q35777555
Plasma thymus and activation-regulated chemokine as an early response marker in classical Hodgkin's lymphomaQ35794450
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphomaQ35849633
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioningQ35986612
Mechanisms of B-cell lymphoma pathogenesisQ36085626
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancerQ36177909
Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.Q36253967
Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trialQ36333526
Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferationQ36362226
Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cellsQ36370860
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.Q36628291
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.Q36654128
Lenalidomide interferes with tumor-promoting properties of nurse-like cells in chronic lymphocytic leukemia.Q36715966
Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trialQ36715971
The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia.Q36892616
Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trialQ36929714
Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation.Q37004749
Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cellsQ37144907
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytesQ37226729
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanomaQ37333645
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptorQ37354362
Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapyQ37427993
Environment-mediated drug resistance: a major contributor to minimal residual diseaseQ37582773
Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcomeQ37659012
Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas.Q37867290
The microenvironment in follicular lymphomaQ37887136
The microenvironment in mantle cell lymphoma: cellular and molecular pathways and emerging targeted therapiesQ37938355
Bruton tyrosine kinase (BTK) and its role in B-cell malignancyQ37997075
Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversiesQ38076576
The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component.Q38122535
The targeting of immunosuppressive mechanisms in hematological malignanciesQ38201231
The tumour microenvironment in B cell lymphomasQ38227748
Recurrent genomic rearrangements in primary testicular lymphoma.Q38387704
Emerging biological insights and novel treatment strategies in primary mediastinal large B-cell lymphomaQ38389777
CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.Q38992830
Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemiaQ39105456
Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphomaQ39433857
Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cellsQ39548715
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viabilityQ39642145
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemiaQ39722770
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistanceQ39798268
Synergistic antitumor effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivoQ39831203
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)531-40
P577publication date2016-05-01
P1433published inHaematologicaQ5638209
P1476titleRole of the tumor microenvironment in mature B-cell lymphoid malignancies
P478volume101

Reverse relations

cites work (P2860)
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