Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial

scientific article published on 14 October 2013

Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2012.48.3685
P932PMC publication ID4878008
P698PubMed publication ID24127452
P5875ResearchGate publication ID257815094

P50authorEdmund K WallerQ59682183
Hillard M. LazarusQ74988477
David RizzieriQ92624494
Philippe ArmandQ95280463
Steven M DevineQ102147361
Chitra HosingQ37840480
Leo GordonQ40235097
Jane WinterQ43103944
P2093author name stringDavid E Avigan
H Kent Holland
Reuven Or
Joseph P Uberti
Stephanie A Gregory
Markus Y Mapara
Yi-Bin Chen
Arnon Nagler
Mark S Kaminski
Joseph W Fay
John M Timmerman
Edward D Ball
David Andorsky
Edie A Weller
James R Mason
Rinat Rotem-Yehudar
P2860cites workPretransplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in aggressive B-cell non-Hodgkin lymphomaQ46333356
Revised response criteria for malignant lymphomaQ47582438
Early FDG-PET assessment in combination with clinical risk scores determines prognosis in recurring lymphomaQ53249218
Cd4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcomeQ53329309
Clinical Outcome following Autologous and Allogeneic Blood and Marrow Transplantation for Relapsed Diffuse Large-Cell Non-Hodgkin’s LymphomaQ57338841
Impact of high-dose chemotherapy followed by auto-SCT for positive interim [18F] FDG-PET diffuse large B-cell lymphoma patientsQ61827013
Treatment with BAT monoclonal antibody decreases tumor burden in a murine model of leukemia/lymphomaQ74628284
Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantationQ77145697
Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography eraQ85821231
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerQ24633070
The PD-1 pathway in tolerance and autoimmunityQ24633549
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced CancerQ27860857
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
PD-1 and its ligands in tolerance and immunityQ28131650
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlatesQ29620051
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.Q33632062
Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomasQ33850163
Immune reconstitution after autologous hematopoietic stem cell transplantationQ34231558
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphomaQ34288599
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignanciesQ34592058
Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab eraQ34621900
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunityQ35870655
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantationQ37100764
Disease staging with positron emission tomography or gallium scanning and use of rituximab predict outcome for patients with diffuse large B-cell lymphoma treated with autologous stem cell transplantation.Q37194968
Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapyQ37761181
The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indicationsQ37809158
Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapyQ39371874
Programmed Death Ligand 1 Is Expressed by Non–Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T CellsQ39548715
BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in miceQ40381443
A monoclonal antibody against a human B lymphoblastoid cell line induces tumor regression in mice.Q41429103
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectdiffuse large B-cell lymphomaQ2626074
B-cell lymphomaQ4833719
phase II clinical trialQ42824440
P304page(s)4199-4206
P577publication date2013-10-14
P1433published inJournal of Clinical OncologyQ400292
P1476titleDisabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
P478volume31

Reverse relations

cites work (P2860)
Q26738729A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints
Q41652576A phase II study of belinostat (PXD101) in relapsed and refractory aggressive B-cell lymphomas: SWOG S0520.
Q59360057A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era
Q28087576A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
Q64125225Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma
Q54960920Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Q36106006Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Q64926172Anti-PD1 and anti-PD-L1 in the treatment of metastatic melanoma.
Q44764023Anti-PD1 antibody: a new approach to treatment of lymphomas
Q46308773Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues
Q26738867B cell regulation of the anti-tumor response and role in carcinogenesis
Q34380489Back to the future! The evolving role of maintenance therapy after hematopoietic stem cell transplantation.
Q38637599Beginning of a novel frontier: T-cell-directed immune manipulation in lymphomas
Q38370539Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma.
Q92644924Bone marrow PD-1 positive T cells reflect tumor mass and prognosis in multiple myeloma
Q38708600Breakthrough therapies in B-cell non-Hodgkin lymphoma.
Q92067138CRISPR/Cas9-Mediated Foxp1 Silencing Restores Immune Surveillance in an Immunocompetent A20 Lymphoma Model
Q38845362Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?
Q52592605Cardiotoxicity of Immunotherapy: Incidence, Diagnosis, and Management
Q28076071Catching up with solid tumor oncology: what is the evidence for a prognostic role of programmed cell death-ligand 1/programmed cell death-1 expression in B-cell lymphomas?
Q39055861Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders
Q58594803Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma
Q38837680Checkpoint Inhibitors and Other Immune Therapies for Hodgkin and Non-Hodgkin Lymphoma
Q38714437Checkpoint Inhibitors for the Treatment of Hodgkin Lymphoma
Q89777704Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma
Q38787776Checkpoint inhibition and cellular immunotherapy in lymphoma
Q92735562Checkpoint inhibition to prevent or treat relapse in allogeneic hematopoietic cell transplantation
Q27025873Checkpoint modulation--A new way to direct the immune system against renal cell carcinoma
Q38289729Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?
Q34671498Clinical Development of Immune Checkpoint Inhibitors
Q38298241Clinical blockade of PD1 and LAG3--potential mechanisms of action
Q38219369Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy
Q38262593Clinical impact of checkpoint inhibitors as novel cancer therapies
Q59350697Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells
Q40971062Clinicopathological analysis of programmed cell death 1 and programmed cell death ligand 1 expression in the tumour microenvironments of diffuse large B cell lymphomas
Q39092611Coevolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia
Q90468289Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma
Q54982413Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies
Q37629874Current Diagnosis and Management of Immune Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitor Therapy
Q90419584Current Perspectives in Cancer Immunotherapy
Q27853176Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers
Q91776774Differential expression of individual transcript variants of PD-1 and PD-L2 genes on Th-1/Th-2 status is guaranteed for prognosis prediction in PCNSL
Q41924371Differentiated tumor immune microenvironment of Epstein-Barr virus-associated and negative gastric cancer: implication in prognosis and immunotherapy.
Q37589543Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful
Q33622342Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?
Q34325329Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation
Q38344404Emerging drugs for diffuse large B-cell lymphoma
Q38652326Emerging immunotherapy in pediatric lymphoma
Q38756923Emerging role of checkpoint blockade therapy in lymphoma
Q38889427Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells.
Q33704061Emerging treatment options for the management of Hodgkin's lymphoma: clinical utility of nivolumab
Q50566797Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy
Q36253967Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.
Q88227428Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients
Q38612233Fast Cars and No Brakes: Autologous Stem Cell Transplantation as a Platform for Novel Immunotherapies
Q89291887Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma
Q55262681Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens
Q36051184Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma
Q38294626Genetic and molecular targets in lymphoma: implications for prognosis and treatment.
Q33632104HLA dependent immune escape mechanisms in B-cell lymphomas: Implications for immune checkpoint inhibitor therapy?
Q35880618Haematological malignancies: at the forefront of immunotherapeutic innovation
Q92999083Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas
Q47141309Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma
Q89433359How I treat primary mediastinal B-cell lymphoma
Q34809019Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway.
Q39156034Human regulatory B cells in health and disease: therapeutic potential.
Q39116985Immune Checkpoint Blockade and Hematopoietic Stem Cell Transplant
Q26830509Immune Checkpoint Blockade in Cancer Therapy
Q26795509Immune Checkpoint Blockade: A New Paradigm in Treating Advanced Cancer
Q41601825Immune Checkpoint Blockers and Ovarian Cancer
Q55106038Immune Checkpoint Inhibitors to Treat Malignant Lymphomas.
Q37091138Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events.
Q51804722Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies.
Q26796307Immune Modulation in Hematologic Malignancies
Q38541811Immune Response in Hepatitis B Virus Infection
Q39446788Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone
Q33645590Immune checkpoint blockade for hematologic malignancies: a review
Q38878902Immune checkpoint blockade in human cancer therapy: lung cancer and hematologic malignancies
Q38710672Immune checkpoint blockade in lymphoid malignancies
Q33638083Immune checkpoint blockade: the role of PD-1-PD-L axis in lymphoid malignancies
Q38396568Immune checkpoint inhibition in lymphoid disease.
Q38787535Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts.
Q45871487Immune checkpoint inhibitors in cancer therapy
Q34309394Immune checkpoint inhibitors in clinical trials
Q97643982Immune checkpoint inhibitors in malignant lymphoma: Advances and perspectives
Q38750608Immune checkpoint pathways: perspectives on myeloid malignancies
Q47143437Immune checkpoints, their control by immunotherapy and ovarian cancer
Q34686944Immune modulation for cancer therapy
Q42974499Immune regulatory effects of panobinostat in patients with Hodgkin lymphoma through modulation of serum cytokine levels and T-cell PD1 expression.
Q57483931Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
Q38424617Immuno-regulatory antibodies for the treatment of cancer
Q38284898Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
Q38821875Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop
Q38803361Immunotherapeutic approaches for the treatment of childhood, adolescent and young adult non-Hodgkin lymphoma
Q38587157Immunotherapies for bladder cancer: a new hope.
Q26781038Immunotherapy for advanced gastric and esophageal cancer: preclinical rationale and ongoing clinical investigations
Q94526314Immunotherapy in hematologic malignancies
Q33593865Immunotherapy in hematologic malignancies: past, present, and future
Q88257809Immunotherapy in lymphoma
Q41592435Immunotherapy of hematological cancers: PD-1 blockade for the treatment of Hodgkin's lymphoma
Q27003955Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?
Q38799409Improving therapeutic activity of anti-CD20 antibody therapy through immunomodulation in lymphoid malignancies
Q43432645Infiltration of CD8 T Cells and Expression of PD-1 and PD-L1 in Synovial Sarcoma
Q38434473Investigational therapies targeting lymphocyte antigens for the treatment of non-Hodgkin's lymphoma
Q38670099Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies
Q28080705Lymphoma: immune evasion strategies
Q52643503Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells
Q52707883Mechanisms of Resistance to PD-1 and PD-L1 Blockade.
Q28385366Mechanisms of action of therapeutic antibodies for cancer
Q90181898Minimal residual disease undetectable by next-generation sequencing predicts improved outcome in CLL after chemoimmunotherapy
Q51450182Modulation of Immune Checkpoints and Graft-versus-Leukemia in Allogeneic Transplants by Antagonizing Vasoactive Intestinal Peptide Signaling
Q39147488Molecular Subtyping in Diffuse Large B Cell Lymphoma: Closer to an Approach of Precision Therapy
Q64999729Molecular remission using low-dose immunotherapy for relapsed refractory Philadelphia chromosome-positive precursor B-cell acute lymphoblastic leukemia post-allogeneic stem cell transplant.
Q34485950NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.
Q27022373New antibody approaches to lymphoma therapy
Q38787141New targeted therapies for malignant lymphoma based on molecular heterogeneity
Q38315779New therapies in non-Hodgkin lymphoma
Q38972343Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies.
Q33421351Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
Q38836740Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers
Q39441297Novel Insights into Membrane Targeting of B Cell Lymphoma.
Q26782270Novel Targeted Agents in Hodgkin and Non-Hodgkin Lymphoma Therapy
Q52336772Novel acquisitions on biology and management of transformed follicular lymphoma
Q26769884Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential
Q27304386Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Q38489700Novel immunologic approaches in lymphoma: unleashing the brakes on the immune system
Q26777394Novel immunotherapies in lymphoid malignancies
Q38391533On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation
Q55281964Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies
Q38262255Overcoming tumor-mediated immunosuppression
Q64883255Overview of Targeted Drugs for Mature B-Cell Non-hodgkin Lymphomas.
Q35770856PD-1 Blockade Can Restore Functions of T-Cells in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma In Vitro
Q39393005PD-1 and cancer: molecular mechanisms and polymorphisms.
Q28069485PD-1 and its ligands are important immune checkpoints in cancer
Q92518269PD-1 blockade for diffuse large B-cell lymphoma after autologous stem cell transplantation
Q38953155PD-1 blockade in Hodgkin's lymphoma: learning new tricks from an old teacher
Q29620878PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
Q47424027PD-1 expression and clinical PD-1 blockade in B-cell lymphomas
Q35713307PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer
Q37429917PD-1 expression on the surface of peripheral blood CD4(+) T cell and its association with the prognosis of patients with diffuse large B-cell lymphoma
Q38996724PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
Q39420466PD-1/PD-L1 inhibitors in haematological malignancies: update 2017.
Q28075712PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
Q37630808PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma
Q37644975PD-L1 expression in EBV-negative diffuse large B-cell lymphoma: clinicopathologic features and prognostic implications.
Q26738361PD-L1 expression in human cancers and its association with clinical outcomes
Q91678519PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling
Q37565475PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells
Q50716088Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL.
Q89777624Pharmacologic agents to prevent and treat relapse after allogeneic hematopoietic cell transplantation
Q49988870Pharmacologic agents to prevent and treat relapse after allogeneic hematopoietic cell transplantation.
Q38233257Pidilizumab in the treatment of diffuse large B-cell lymphoma
Q38294189Plasmacytoid dendritic cells, a role in neoplastic prevention and progression
Q38568358Post-autologous transplant maintenance therapies in lymphoid malignancies: are we there yet?
Q47886065Post-autologous transplant maintenance therapies in lymphoma: current state and future directions
Q47967336Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma
Q88797028Prevention and treatment of relapse after stem cell transplantation in lymphoid malignancies
Q48252543Primary central nervous system diffuse large B-cell lymphoma has poorer immune cell infiltration and prognosis than its peripheral counterpart
Q47567402Primary mediastinal B-cell lymphoma: biology and evolving therapeutic strategies.
Q58582618Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining
Q57191808Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences
Q36219679Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma.
Q64235333Prognostic value of PD-L1 expression in patients with pancreatic cancer: A PRISMA-compliant meta-analysis
Q49211560Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure
Q38460223Programmed cell death-1 inhibition in lymphoma.
Q38844205Programmed death-1 immune checkpoint blockade in the treatment of hematological malignancies
Q38806070Programming the immune checkpoint to treat hematologic malignancies.
Q26777557Promises and paradoxes of regulatory T cells in inflammatory bowel disease
Q38643567Prospective immunotherapies in childhood sarcomas: PD1/PDL1 blockade in combination with tumor vaccines
Q26779221Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications
Q38174058Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients.
Q40338899Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based study
Q91525873Real-time prediction of patient immune cell modulation during irreversible electroporation therapy
Q26784108Recent advances in post autologous transplantation maintenance therapies in B-cell non-Hodgkin lymphomas
Q38782141Recent molecular and therapeutic advances in B-cell non-Hodgkin lymphoma in children
Q47140355Recurrent glioma clinical trial, CheckMate-143: the game is not over yet.
Q38497066Regulatory B cells in anti-tumor immunity
Q51234188Renal effects of immune checkpoint inhibitors
Q39034069Report on the 56th ASH Annual Meeting, San Francisco, 4-9 December 2014.
Q38566770Risk of cutaneous toxicities in patients with solid tumors treated with immune checkpoint inhibitors: a meta-analysis.
Q38591135Risk of elevated transaminases in cancer patients treated with immune checkpoint inhibitors: a meta-analysis.
Q38699309Risk of endocrine complications in cancer patients treated with immune check point inhibitors: a meta-analysis.
Q39947131Risk of pneumonitis in cancer patients treated with immune checkpoint inhibitors: a meta-analysis
Q26748775Role of the tumor microenvironment in mature B-cell lymphoid malignancies
Q34391446Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
Q42370605Safety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials
Q36562341Serum levels of soluble programmed death ligand 1 predict treatment response and progression free survival in multiple myeloma
Q38357127Shifting paradigms in the treatment of chronic lymphocytic leukemia
Q36522770Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies
Q52808766Soluble programmed death-ligand 1 as a prognostic biomarker for overall survival in patients with diffuse large B-cell lymphoma: a replication study and combined analysis of 508 patients.
Q50041876Strategies for clinical development of monoclonal antibodies beyond first-in-human trials: tested doses and rationale for dose selection
Q58615647Strategies to improve outcomes of autologous hematopoietic cell transplant in lymphoma
Q38267888Structural genomic alterations in primary mediastinal large B-cell lymphoma
Q39078341T cell exhaustion: from pathophysiological basics to tumor immunotherapy
Q47217197T cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma
Q47712161Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors
Q54685667Targeted therapies: programmed death: improving DLBCL.
Q38963420Targeting Immune Checkpoints in Hematologic Malignancies
Q92656858Targeting immune cells for cancer therapy
Q28072012Targeting immune checkpoints in malignant glioma
Q39153358Targeting the programmed death-1 pathway in lymphoid neoplasms.
Q28088496The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma
Q38285859The PD-1/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy
Q28066941The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
Q38388590The Role of Anti-PD-1/PD-L1 Agents in Melanoma: Progress to Date
Q53321210The Use of Anti-CD40 mAb in Cancer
Q26797478The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients
Q26766066The effect of chemotherapy on programmed cell death 1/programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
Q37687345The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: a meta-analysis
Q48173100The emerging role of immune checkpoint based approaches in AML and MDS.
Q38791036The emerging role of immune checkpoint inhibition in malignant lymphoma
Q38216836The expanding horizon of immunotherapy in the treatment of malignant disorders: allogeneic hematopoietic stem cell transplantation and beyond.
Q38691172The immune system and cancer evasion strategies: therapeutic concepts
Q39061630The landscape of new drugs in lymphoma
Q64110378The prognostic and clinicopathological significance of PD-L1 expression in patients with diffuse large B-cell lymphoma: a meta-analysis
Q41695080The role of novel immunotherapies in non-Hodgkin lymphoma
Q38227748The tumour microenvironment in B cell lymphomas
Q34443923Therapeutic uses of anti-PD-1 and anti-PD-L1 antibodies
Q38586991Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.
Q26851974Transformed follicular non-Hodgkin lymphoma
Q39091822Treatment approaches of hard-to-treat non-Hodgkin lymphomas
Q47393365Trial watch: Immune checkpoint blockers for cancer therapy
Q89455200Utilisation des inhibiteurs de PD-1 dans les hémopathies lymphoïdes
Q39043404Vaccine strategies for the treatment of lymphoma: preclinical progress and clinical trial update
Q54839137What have we learned from immunotherapy? Report from the 3rd and 4th meetings of the Campania Society of Oncology Immunotherapy (SCITO).
Q88121074[Advances on PD-1/PD-L1 inhibitors in multiple myeloma]
Q88515456[Research progress on PD-1 inhibitors in lymphoma therapy]
Q89550338[Study on enhancing the killing activity of chemotherapy drugs by PD-1 inhibitor on Raji cell line]
Q85963384[The research progress of costimulatory molecule B7 family in hematological malignancy]
Q35546869siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice

Search more.