Pediatric Cancer Immunotherapy: Opportunities and Challenges

scientific article published on 01 October 2018

Pediatric Cancer Immunotherapy: Opportunities and Challenges is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S40272-018-0297-X
P932PMC publication ID6153971
P698PubMed publication ID29948928

P2093author name stringTimothy P Cripe
Chun-Yu Chen
Mary Frances Wedekind
Nicholas L Denton
P2860cites workChimeric antigen receptor-modified T cells in chronic lymphoid leukemiaQ24594920
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Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing programQ24627862
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Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer ProgressionQ26863784
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Cancer immunoediting: integrating immunity's roles in cancer suppression and promotionQ27860475
The blockade of immune checkpoints in cancer immunotherapyQ27860852
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Combination Approaches with Immune-Checkpoint Blockade in Cancer TherapyQ28066199
Clinical significance of tumor-infiltrating lymphocytes in breast cancerQ28070214
Immune checkpoint blockade: a common denominator approach to cancer therapyQ28083981
Immunotherapy for Bone and Soft Tissue SarcomasQ28088363
Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 BlockadeQ28119095
Ipilimumab plus dacarbazine for previously untreated metastatic melanomaQ28131634
Phase II Study of the Efficacy and Safety of Pembrolizumab for Relapsed/Refractory Classic Hodgkin LymphomaQ36356089
Neuroblastomas vary widely in their sensitivities to herpes simplex virotherapy unrelated to virus receptors and susceptibilityQ36547314
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemiaQ36619703
Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinomaQ36621122
The anticancer immune response: indispensable for therapeutic success?Q36677608
Immunotherapy in pediatric malignancies: current status and future perspectivesQ36691818
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysisQ36750008
Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphomaQ36822162
Feasibility of Pegylated Interferon in Children and Young Adults With Resected High-Risk Melanoma.Q36927476
Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II studyQ36999978
Immune-related response evaluations during immune-checkpoint inhibitor therapy: establishing a "common language" for the new arena of cancer treatmentQ37024590
Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignanciesQ37058110
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcomaQ37125088
A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancerQ37141237
Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapyQ37256974
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.Q37262424
Phase I Clinical Trial of Ipilimumab in Pediatric Patients with Advanced Solid TumorsQ37265479
Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology GroupQ37439345
Unleashing the therapeutic potential of NOD-like receptorsQ37502679
Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapyQ37575208
REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancerQ37602536
Mifamurtide: a review of its use in the treatment of osteosarcomaQ37756110
The CD4-like molecule LAG-3, biology and therapeutic applicationsQ37818246
Mifamurtide for the treatment of nonmetastatic osteosarcomaQ37827876
Immune parameters affecting the efficacy of chemotherapeutic regimensQ37848665
Tumor-infiltrating lymphocytes and their significance in melanoma prognosisQ38164610
Regulatory T cells in cancer immunotherapyQ38177627
Sarcoma immunotherapy: past approaches and future directionsQ38207986
Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia.Q38256888
Translational biology of osteosarcomaQ38260633
CTLA-4 and PD-1 Pathway Blockade: Combinations in the ClinicQ38340574
PD-L1 Expression as a Predictive Biomarker in Cancer ImmunotherapyQ38361400
Checkpoint blockade in combination with cancer vaccinesQ38611369
Limitations and opportunities for immune checkpoint inhibitors in pediatric malignanciesQ38670099
Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer PatientsQ38684847
Predictive biomarkers for checkpoint inhibitor-based immunotherapyQ38786289
Targeting the PD-1 pathway in pediatric solid tumors and brain tumorsQ38819982
Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?Q38845362
Immune checkpoint inhibitor combinations in solid tumors: opportunities and challengesQ38878906
Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions.Q38902256
Progress and opportunities for immune therapeutics in osteosarcomaQ38948905
Drugs in early clinical development for the treatment of osteosarcomaQ38955517
Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung CancerQ38975751
Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ.Q39017038
Treatment-related Death in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis.Q39022649
Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.Q39096595
Double‐deleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumorsQ39132287
Immunomodulatory monoclonal antibodies combined with peptide vaccination provide potent immunotherapy in an aggressive murine neuroblastoma modelQ39155565
Harnessing the Immunotherapy Revolution for the Treatment of Childhood CancersQ39213960
Current Immunotherapeutic Strategies to Enhance Oncolytic VirotherapyQ39387174
Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia.Q39408728
Biomarkers of response to PD-1/PD-L1 inhibition.Q39426306
Modulation of the Intratumoral Immune Landscape by Oncolytic Herpes Simplex Virus VirotherapyQ39427382
Combination of lentivector immunization and low‐dose chemotherapy or PD‐1/PD‐L1 blocking primes self‐reactive T cells and induces anti‐tumor immunityQ39549328
Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenograftsQ39562583
Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agentsQ39581986
Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trialQ39704999
Feasibility of high-dose interleukin-2 in heavily pretreated pediatric cancer patientsQ39714477
Comprehensive Immunohistochemical Study of Programmed Cell Death Ligand 1 (PD-L1): Analysis in 5536 Cases Revealed Consistent Expression in Trophoblastic TumorsQ39783701
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trialQ40186710
Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 studyQ40295439
Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic LeukemiaQ40312849
The B7 and CD28 receptor familiesQ40392461
A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancerQ40405703
CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interactionQ40418115
Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.Q40479866
Clinical and prognostic significance of PD-1 and PD-L1 expression in sarcomasQ40648999
Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic LeukemiaQ40705613
Evaluation of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell CarcinomaQ41311511
Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastomaQ41316816
Low Frequency of Programmed Death Ligand 1 Expression in Pediatric CancersQ41531023
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.Q41735884
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.Q41974388
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacyQ41983246
Sipuleucel-T immune parameters correlate with survival: an analysis of the randomized phase 3 clinical trials in men with castration-resistant prostate cancerQ42032055
TGF-β Inhibition Improves Oncolytic Herpes Viroimmunotherapy in Murine Models of RhabdomyosarcomaQ42373489
Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8+ lymphocytes in primary sarcomas is subtype dependent.Q42378536
T-cell immunotherapy: looking forwardQ42549120
A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancerQ42940016
Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α.Q43100151
A phase II trial of human recombinant interleukin-2 administered as a 4-day continuous infusion for children with refractory neuroblastoma, non-Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A Childrens Cancer Group studyQ46141389
Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissuesQ46308773
Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemiaQ46385489
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trialQ46559484
Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors.Q47409937
Severe cerebral edema following nivolumab treatment for pediatric glioblastoma: case report.Q48425815
Cancer: a biological approach. III. Viruses associated with neoplastic conditions. IV. Practical applicationsQ50417083
KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors.Q51823230
Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.Q53396593
Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T-lymphocyte infiltration and affect tumour progression.Q54396439
CD8⁺ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma.Q54586145
Immune Checkpoint Inhibitors for Urologic Cancer: The Tip of the Iceberg?Q56895892
Genetic basis for clinical response to CTLA-4 blockadeQ56896243
Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid StructuresQ56965922
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survivalQ56986695
II. Contribution to the Knowledge of SarcomaQ58766392
A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 aloneQ68815180
Localization of GD2-specific monoclonal antibody 3F8 in human osteosarcomaQ70358837
Immunologic effects of intermediate-dose IL-2 i.v. after autologous hematopoietic cell transplantation in pediatric solid tumorsQ73656453
Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastomaQ80789780
Interferon-alpha as the only adjuvant treatment in high-grade osteosarcoma: long term results of the Karolinska Hospital seriesQ81104210
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancersQ28256331
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
The role of the CD28 receptor during T cell responses to antigenQ28263234
Enhancement of antitumor immunity by CTLA-4 blockadeQ28275730
Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case ReportsQ28553328
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaQ29615443
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Chimeric antigen receptor T cells for sustained remissions in leukemiaQ29617588
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patientsQ29617771
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancerQ29619483
Chimeric antigen receptor-modified T cells for acute lymphoid leukemiaQ29620130
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2Q29620608
Nivolumab and ipilimumab versus ipilimumab in untreated melanomaQ29620657
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphomaQ29620878
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung CancerQ29620902
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung CancerQ29620913
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemiasQ29622949
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good RQ30357731
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapiesQ30827633
Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology GroupQ33398810
Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic LeukemiaQ33437770
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.Q33667690
NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemiaQ33710760
Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma ModelsQ33725706
Immunotherapy of childhood cancer: from biologic understanding to clinical application.Q33752982
Ipilimumab and Its Toxicities: A Multidisciplinary ApproachQ33777476
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokinesQ33838538
„Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cellQ33906475
Review of mifamurtide in the treatment of patients with osteosarcomaQ33947618
Tumor-associated macrophages and survival in classic Hodgkin's lymphomaQ33962334
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 studyQ34042800
Identification of a putative regulator of early T cell activation genesQ34171263
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.Q34269503
T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 bindingQ34382009
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenanceQ34472025
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced MelanomaQ34478015
Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II studyQ34488726
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapyQ34522172
Liposomal muramyl tripeptide phosphatidyl ethanolamine: a safe and effective agent against osteosarcoma pulmonary metastasesQ34588395
Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging studyQ34614776
PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumorsQ34644359
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.Q34657638
Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian studyQ34707770
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitisQ34720087
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infectionQ34734469
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology GroupQ34743615
Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma.Q34996698
The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational researchQ35000726
The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.Q35009076
Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomasQ35070603
MHC class I antigens, immune surveillance, and tumor immune escape.Q35110945
Phase 1 study of intratumoral Pexa-Vec (JX-594), an oncolytic and immunotherapeutic vaccinia virus, in pediatric cancer patientsQ35153121
A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man; a critical analysis of 30 inoperable cases treated by Coley's mixed toxins, in which diagnosis was confirmed by microscopic examQ35222693
Preclinical evidence that PD1 blockade cooperates with cancer vaccine TEGVAX to elicit regression of established tumorsQ35412152
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive SarcomaQ35598804
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastomaQ35604043
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcomaQ35624496
IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.Q35690979
Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology GroupQ35880614
Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.Q35904943
Mifamurtide in metastatic and recurrent osteosarcoma: a patient access study with pharmacokinetic, pharmacodynamic, and safety assessmentsQ35945493
Increased CTLA-4(+) T cells and an increased ratio of monocytes with loss of class II (CD14(+) HLA-DR(lo/neg)) found in aggressive pediatric sarcoma patientsQ35965142
Tumor infiltrating lymphocytes (TILs) improve prognosis in patients with triple negative breast cancer (TNBC).Q36060283
Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma.Q36072022
Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology groupQ36097717
Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell CarcinomaQ36132720
Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancerQ36134480
Cellular and Antibody Based Approaches for Pediatric Cancer ImmunotherapyQ36261159
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.Q36284594
Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for GliomaQ36321176
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue5
P921main subjectimmunotherapyQ1427096
precursor B-cell lymphoblastic leukemiaQ5973974
P304page(s)395-408
P577publication date2018-10-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inPediatric DrugsQ15767256
P1476titlePediatric Cancer Immunotherapy: Opportunities and Challenges
P478volume20

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cites work (P2860)
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