Ursolic acid suppresses leptin-induced cell proliferation in rat vascular smooth muscle cells

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Ursolic acid suppresses leptin-induced cell proliferation in rat vascular smooth muscle cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1139/CJPP-2016-0398
P698PubMed publication ID28177667

P2093author name stringChiang-Chin Tsai
Su-Yin Chiang
Ming-Fen Lee
Weng-Cheng Chang
Ya-Mei Yu
Yu-Wen Tzeng
P2860cites workPotential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitroQ28115650
Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cellsQ28533451
Serum immunoreactive-leptin concentrations in normal-weight and obese humansQ29617230
Smooth muscle cells and the pathogenesis of the lesions of atherosclerosisQ33613211
The transcription factor NF-kappa B and the regulation of vascular cell functionQ34080327
Adipokines: molecular links between obesity and atheroslcerosisQ34384883
Reactive oxygen species in the vasculature: molecular and cellular mechanismsQ35569201
Role of matrix metalloproteinases in vascular remodelingQ35626750
Mechanisms of endothelial dysfunction in obesityQ36176668
Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injuryQ36926500
The autocrine and paracrine roles of adipokines.Q37641459
Genistein suppresses leptin-induced proliferation and migration of vascular smooth muscle cells and neointima formation.Q37662916
Reactive oxygen species as mediators of signal transduction in cardiovascular diseaseQ37828680
Adipokines as mediators of endothelial function and atherosclerosisQ38075281
Adipokines in obesityQ38082962
Obesity and atherosclerosis: mechanistic insights.Q38347689
Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological ActivitiesQ38648767
Ursolic acid (UA): A metabolite with promising therapeutic potentialQ38699263
Antiangiogenic activity of ursolic acid.Q39704685
Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signalingQ39721038
Ursolic acid plays a protective role in obesity-induced cardiovascular diseasesQ39908905
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligandsQ40692915
The A10 cell line: a model for neonatal, neointimal, or differentiated vascular smooth muscle cells?Q41066607
Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase-2 (MMP-2) via NAD(P)H Oxidase–Derived Reactive Oxygen SpeciesQ44443254
Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cellsQ46041346
Ursolic acid inhibits neointima formation in the rat carotid artery injury modelQ46515597
Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.Q46570591
Ellagic acid suppresses oxidised low-density lipoprotein-induced aortic smooth muscle cell proliferation: studies on the activation of extracellular signal-regulated kinase 1/2 and proliferating cell nuclear antigen expressionQ46816015
Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K.Q47876064
Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-kappaB.Q53324906
P433issue7
P304page(s)811-818
P577publication date2017-01-29
P1433published inCanadian Journal of Physiology and PharmacologyQ5030248
P1476titleUrsolic acid suppresses leptin-induced cell proliferation in rat vascular smooth muscle cells
P478volume95

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Q47688121Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cellscites workP2860

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