Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells

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Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...863872W
P356DOI10.1371/JOURNAL.PONE.0063872
P3181OpenCitations bibliographic resource ID3489069
P932PMC publication ID3667855
P698PubMed publication ID23737956
P5875ResearchGate publication ID237057930

P2093author name stringWei Guo
Wenlin Huang
Yun Tian
Xiaohong Zhang
Wangbing Chen
Wuguo Deng
Dingbo Shi
Jingshu Wang
Huijuan Qiu
Lingyi Fu
Liqun Liu
Jianding Cheng
P2860cites workInterferon-gamma suppresses cyclooxygenase-2 promoter activity by inhibiting C-Jun and C/EBPbeta bindingQ80447561
High expression of the transcriptional co-activator p300 predicts poor survival in resectable non-small cell lung cancersQ83729555
Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivoQ84442294
Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cellsQ24299207
p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repairQ30422684
Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signalingQ33999059
Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2.Q34058507
Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathwaysQ34199851
Ursolic acid enhances mouse liver regeneration after partial hepatectomyQ34237656
Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivoQ36172737
Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial adenocarcinoma in vitro and in vivoQ36424321
Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in VivoQ36571885
High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinomaQ36632043
Cyclo-oxygenase 2 up-regulates the effect of multidrug resistanceQ37650780
Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural productQ37854752
Epigenetic modifications of metastasis suppressor genes in colon cancer metastasisQ37901302
Enhancement of colon carcinogenesis by prostaglandin E2 administrationQ38354194
Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signalingQ39240972
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.Q39283341
Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cellsQ39396408
Expression of MMP2 and MMP9 (gelatinases A and B) in human colon cancer cellsQ39484806
Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancerQ39581667
A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon CancerQ39671583
Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activationQ39791378
Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediatorsQ40614798
Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectumQ41842396
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and bindingQ41905999
Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin–agarose pulldown assayQ42452924
Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activationQ42528542
Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives.Q42964415
Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virusQ43014527
Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cellsQ43106199
Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivationQ44536503
The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model.Q46037878
A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract.Q46458052
Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer.Q46625528
Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer.Q53266747
The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathwayQ64379016
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcolon cancerQ18555025
P304page(s)e63872
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleUrsolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells
P478volume8

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cites work (P2860)
Q36053940Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells
Q55316813Cardamonin reduces chemotherapy resistance of colon cancer cells via the TSP50/NF-κB pathway in vitro.
Q90273279Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction
Q35108020Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents
Q35532344Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts
Q33792750In Vitro Antiproliferative Activity of Extracts of Carlina acaulis subsp. caulescens and Carlina acanthifolia subsp. utzka
Q37531850Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer
Q38997510Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments
Q41635155Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts.
Q42923687Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis
Q96304222The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7
Q39002762The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin.
Q60926346Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation
Q42005675Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation
Q34474342Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells
Q53651729Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKα-mediated reduction of DNA methyltransferase 1.
Q36273873Ursolic acid suppresses leptin-induced cell proliferation in rat vascular smooth muscle cells
Q38965144Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline.
Q37645486Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum
Q28830045Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1
Q33592858Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.
Q34125151Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?

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